7JUM
 
 | | Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01 | | Descriptor: | Gametocyte surface protein P230, Neutralizing antibody, LMIV230-01 Single-chain Fv | | Authors: | Tolia, N, Tang, W.K. | | Deposit date: | 2020-08-20 | | Release date: | 2021-03-31 | | Last modified: | 2021-04-07 | | Method: | X-RAY DIFFRACTION (1.998 Å) | | Cite: | A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.
Nat Commun, 12, 2021
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3RRC
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7K3Z
 | | P. falciparum Cpn60 D474A mutant bound to ATP | | Descriptor: | 60 kDa chaperonin, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | Authors: | Tolia, N.H, Shi, D, Nguyen, B. | | Deposit date: | 2020-09-14 | | Release date: | 2021-04-21 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.69 Å) | | Cite: | Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
Sci Rep, 11, 2021
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4NUV
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4QJB
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4JNO
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4NUU
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4K2U
 | | Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment | | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, Erythrocyte binding antigen 175, ... | | Authors: | Tolia, N.H. | | Deposit date: | 2013-04-09 | | Release date: | 2013-06-12 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Plos Pathog., 9, 2013
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1ZRO
 | | Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose | | Descriptor: | CHLORIDE ION, SULFATE ION, erythrocyte binding antigen region II | | Authors: | Tolia, N.H, Enemark, E.J, Sim, B.K, Joshua-Tor, L. | | Deposit date: | 2005-05-19 | | Release date: | 2005-08-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum.
Cell(Cambridge,Mass.), 122, 2005
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1ZRL
 | | Crystal structure of EBA-175 Region II (RII) | | Descriptor: | CHLORIDE ION, SULFATE ION, erythrocyte binding antigen region II | | Authors: | Tolia, N.H, Enemark, E.J, Sim, B.K, Joshua-Tor, L. | | Deposit date: | 2005-05-19 | | Release date: | 2005-08-09 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum.
Cell(Cambridge,Mass.), 122, 2005
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5TSZ
 | | Crystal structure of Plasmodium vivax CelTOS | | Descriptor: | Pv cell-traversal protein, SODIUM ION | | Authors: | Tolia, N.H, Jimah, J.R. | | Deposit date: | 2016-10-31 | | Release date: | 2016-12-28 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.002 Å) | | Cite: | Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption.
Elife, 5, 2016
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6OAO
 | | Structure of DBP in complex with human neutralizing antibody 092096 | | Descriptor: | Antibody 092096 single chain variable fragment, Duffy binding surface protein region II, SULFATE ION | | Authors: | Urusova, D, Tolia, N.H. | | Deposit date: | 2019-03-18 | | Release date: | 2019-06-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.497 Å) | | Cite: | Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Nat Microbiol, 4, 2019
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6WG9
 | | Crystal structure of tetracycline destructase Tet(X7) | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Tetracycline destructase Tet(X7) | | Authors: | Kumar, H, Tolia, N.H. | | Deposit date: | 2020-04-05 | | Release date: | 2021-02-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance.
Commun Biol, 3, 2020
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8GIF
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8GIE
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8GID
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5F3J
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6B2N
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1R6Z
 | | The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion) | | Descriptor: | Chimera of Maltose-binding periplasmic protein and Argonaute 2, NICKEL (II) ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Song, J.J, Liu, J, Tolia, N.H, Schneiderman, J, Smith, S.K, Martienssen, R.A, Hannon, G.J, Joshua-Tor, L. | | Deposit date: | 2003-10-17 | | Release date: | 2004-01-13 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.
Nat.Struct.Biol., 10, 2003
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6O38
 | | Structure of a chaperone-substrate complex | | Descriptor: | Acinetobacter secreted protease CpaA, SULFATE ION, Type II secretion chaperone CpaB, ... | | Authors: | Urusova, D.V, Tolia, N.H. | | Deposit date: | 2019-02-26 | | Release date: | 2019-07-24 | | Last modified: | 2019-09-25 | | Method: | X-RAY DIFFRACTION (2.595 Å) | | Cite: | The structure ofAcinetobacter-secreted protease CpaA complexed with its chaperone CpaB reveals a novel mode of a T2SS chaperone-substrate interaction.
J.Biol.Chem., 294, 2019
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6OAN
 | | Structure of DBP in complex with human neutralizing antibody 053054 | | Descriptor: | Antibody 053054 single chain variable fragment, Duffy binding surface protein region II, SULFATE ION | | Authors: | Urusova, D, Tolia, N.H. | | Deposit date: | 2019-03-18 | | Release date: | 2019-06-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Nat Microbiol, 4, 2019
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8DCC
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4GF2
 | | Crystal structure of Plasmodium falciparum Erythrocyte Binding Antigen 140 (PfEBA-140/BAEBL) | | Descriptor: | Erythrocyte binding antigen 140, GLYCEROL | | Authors: | Lin, D.H, Malpede, B.M, Batchelor, J.D, Tolia, N.H. | | Deposit date: | 2012-08-02 | | Release date: | 2012-09-26 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion.
J.Biol.Chem., 287, 2012
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4YFS
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8EZL
 | | Pfs25 in complex with transmission-reducing antibody AS01-50 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-50, ... | | Authors: | Shukla, N, Tang, W.K, Tolia, N.H. | | Deposit date: | 2022-11-01 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023
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