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PDB: 60 件
7JUM
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Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01
分子名称: Gametocyte surface protein P230, Neutralizing antibody, LMIV230-01 Single-chain Fv
著者Tolia, N, Tang, W.K.
登録日2020-08-20
公開日2021-03-31
最終更新日2021-04-07
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.
Nat Commun, 12, 2021
3RRC
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Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein
分子名称: 1,2-ETHANEDIOL, Duffy receptor, PHOSPHATE ION
著者Tolia, N.H.
登録日2011-04-29
公開日2011-07-13
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC.
Nat.Struct.Mol.Biol., 18, 2011
7K3Z
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P. falciparum Cpn60 D474A mutant bound to ATP
分子名称: 60 kDa chaperonin, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Tolia, N.H, Shi, D, Nguyen, B.
登録日2020-09-14
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.69 Å)
主引用文献Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
Sci Rep, 11, 2021
4NUV
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Heterotetramer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
分子名称: Duffy antigen/chemokine receptor, Duffy receptor, GLYCEROL
著者Tolia, N.H.
登録日2013-12-04
公開日2014-02-05
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC.
Plos Pathog., 10, 2014
4QJB
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Crystal structure of the sugar phosphatase PfHAD1 from Plasmodium falciparum
分子名称: CHLORIDE ION, Haloacid dehalogenase-like hydrolase, MAGNESIUM ION
著者Tolia, N.H, Park, J.
登録日2014-06-03
公開日2014-07-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites.
Nat Commun, 5, 2014
4JNO
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Crystal structure of Plasmodium falciparum Erythrocyte Binding Antigen 140 (PfEBA-140/BAEBL) Region II in complex with sialyllactose
分子名称: BAEBL protein, N-acetyl-alpha-neuraminic acid
著者Tolia, N.H.
登録日2013-03-15
公開日2013-03-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Molecular Basis for Sialic Acid-dependent Receptor Recognition by the Plasmodium falciparum Invasion Protein Erythrocyte-binding Antigen-140/BAEBL.
J.Biol.Chem., 288, 2013
4NUU
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Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
分子名称: Duffy antigen/chemokine receptor, Duffy receptor
著者Tolia, N.H.
登録日2013-12-04
公開日2014-02-05
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC.
Plos Pathog., 10, 2014
4K2U
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Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment
分子名称: Antibody Heavy Chain, Antibody Light Chain, Erythrocyte binding antigen 175, ...
著者Tolia, N.H.
登録日2013-04-09
公開日2013-06-12
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Plos Pathog., 9, 2013
1ZRO
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Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose
分子名称: CHLORIDE ION, SULFATE ION, erythrocyte binding antigen region II
著者Tolia, N.H, Enemark, E.J, Sim, B.K, Joshua-Tor, L.
登録日2005-05-19
公開日2005-08-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum.
Cell(Cambridge,Mass.), 122, 2005
1ZRL
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Crystal structure of EBA-175 Region II (RII)
分子名称: CHLORIDE ION, SULFATE ION, erythrocyte binding antigen region II
著者Tolia, N.H, Enemark, E.J, Sim, B.K, Joshua-Tor, L.
登録日2005-05-19
公開日2005-08-09
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum.
Cell(Cambridge,Mass.), 122, 2005
5TSZ
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Crystal structure of Plasmodium vivax CelTOS
分子名称: Pv cell-traversal protein, SODIUM ION
著者Tolia, N.H, Jimah, J.R.
登録日2016-10-31
公開日2016-12-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.002 Å)
主引用文献Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption.
Elife, 5, 2016
6OAO
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Structure of DBP in complex with human neutralizing antibody 092096
分子名称: Antibody 092096 single chain variable fragment, Duffy binding surface protein region II, SULFATE ION
著者Urusova, D, Tolia, N.H.
登録日2019-03-18
公開日2019-06-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.497 Å)
主引用文献Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Nat Microbiol, 4, 2019
6WG9
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Crystal structure of tetracycline destructase Tet(X7)
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Tetracycline destructase Tet(X7)
著者Kumar, H, Tolia, N.H.
登録日2020-04-05
公開日2021-02-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance.
Commun Biol, 3, 2020
8GIF
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BU of 8gif by Molmil
Crystal structure of a designed single-component Plasmodium falciparum AMA1-RON2L insertion fusion immunogen 3
分子名称: Apical membrane antigen 1, rhoptry neck protein 2 chimera
著者Patel, P.N, Tolia, N.H.
登録日2023-03-14
公開日2023-08-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Nat Commun, 14, 2023
8GIE
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Crystal structure of a designed single-component Plasmodium falciparum AMA1-RON2L insertion fusion immunogen 2
分子名称: Apical membrane antigen 1, rhoptry neck protein 2 chimera
著者Patel, P.N, Tolia, N.H.
登録日2023-03-14
公開日2023-08-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Nat Commun, 14, 2023
8GID
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Crystal structure of a strain-transcending single-component Plasmodium falciparum AMA1-RON2L structure-based design immunogen 1 (SBD1)
分子名称: Apical membrane antigen 1, rhoptry neck protein 2 chimera
著者Patel, P.N, Tolia, N.H.
登録日2023-03-14
公開日2023-08-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Nat Commun, 14, 2023
5F3J
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Crystal structure of DBP in complex with inhibitory monoclonal antibody 2D10
分子名称: Antibody 2D10 single chain variable fragment, Duffy receptor
著者Chen, E, Salinas, N.D, Tolia, N.H.
登録日2015-12-02
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.001 Å)
主引用文献Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
6B2N
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Crystal structure of TEM-1 beta-lactamase mutant M182N
分子名称: Beta-lactamase TEM, SULFATE ION
著者Jimah, J.R, Tolia, N.H.
登録日2017-09-20
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.
ACS Cent Sci, 3, 2017
1R6Z
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The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)
分子名称: Chimera of Maltose-binding periplasmic protein and Argonaute 2, NICKEL (II) ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Song, J.J, Liu, J, Tolia, N.H, Schneiderman, J, Smith, S.K, Martienssen, R.A, Hannon, G.J, Joshua-Tor, L.
登録日2003-10-17
公開日2004-01-13
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.
Nat.Struct.Biol., 10, 2003
6O38
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Structure of a chaperone-substrate complex
分子名称: Acinetobacter secreted protease CpaA, SULFATE ION, Type II secretion chaperone CpaB, ...
著者Urusova, D.V, Tolia, N.H.
登録日2019-02-26
公開日2019-07-24
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (2.595 Å)
主引用文献The structure ofAcinetobacter-secreted protease CpaA complexed with its chaperone CpaB reveals a novel mode of a T2SS chaperone-substrate interaction.
J.Biol.Chem., 294, 2019
6OAN
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Structure of DBP in complex with human neutralizing antibody 053054
分子名称: Antibody 053054 single chain variable fragment, Duffy binding surface protein region II, SULFATE ION
著者Urusova, D, Tolia, N.H.
登録日2019-03-18
公開日2019-06-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Nat Microbiol, 4, 2019
8DCC
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SARS-CoV-2 Receptor-Binding Domain SPEEDesign Immunogen 3 Bound to P2B-2F6 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, P2B-2F6 Fab heavy chain, P2B-2F6 Fab light chain, ...
著者Dickey, T.D, Tolia, N.H.
登録日2022-06-16
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response.
Sci Adv, 8, 2022
4GF2
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Crystal structure of Plasmodium falciparum Erythrocyte Binding Antigen 140 (PfEBA-140/BAEBL)
分子名称: Erythrocyte binding antigen 140, GLYCEROL
著者Lin, D.H, Malpede, B.M, Batchelor, J.D, Tolia, N.H.
登録日2012-08-02
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion.
J.Biol.Chem., 287, 2012
4YFS
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Structure of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for malaria vaccine design
分子名称: Duffy receptor
著者Chen, E, Tolia, N.H.
登録日2015-02-25
公開日2015-03-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design.
Plos Negl Trop Dis, 9, 2015
8EZL
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Pfs25 in complex with transmission-reducing antibody AS01-50
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-50, ...
著者Shukla, N, Tang, W.K, Tolia, N.H.
登録日2022-11-01
公開日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023

 

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