4L7I
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![BU of 4l7i by Molmil](/molmil-images/mine/4l7i) | Crystal structure of S-Adenosylmethionine synthase from Sulfolobus solfataricus complexed with SAM and PPi | Descriptor: | DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Wang, F, Hurley, K.A, Helmich, K.E, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2013-06-13 | Release date: | 2013-07-03 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.189 Å) | Cite: | Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. Febs J., 281, 2014
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4HPV
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![BU of 4hpv by Molmil](/molmil-images/mine/4hpv) | Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus | Descriptor: | S-adenosylmethionine synthase | Authors: | Wang, F, Hurley, K.A, Helmich, K.E, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2012-10-24 | Release date: | 2012-11-14 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.214 Å) | Cite: | Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. Febs J., 281, 2014
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4Q31
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![BU of 4q31 by Molmil](/molmil-images/mine/4q31) | The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, FORMIC ACID, ... | Authors: | Tan, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2014-04-10 | Release date: | 2014-05-07 | Last modified: | 2017-03-08 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate. Struct Dyn, 3, 2016
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1MP4
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![BU of 1mp4 by Molmil](/molmil-images/mine/1mp4) | W224H VARIANT OF S. ENTERICA RmlA | Descriptor: | URIDINE-5'-DIPHOSPHATE-GLUCOSE, W224H Variant of S. Enterica RmlA Bound to UDP-Glucose | Authors: | Barton, W.A, Biggins, J.B, Jiang, J, Thorson, J.S, Nikolov, D.B. | Deposit date: | 2002-09-11 | Release date: | 2002-10-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering Proc.Natl.Acad.Sci.USA, 99, 2002
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4XRR
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![BU of 4xrr by Molmil](/molmil-images/mine/4xrr) | Crystal structure of cals8 from micromonospora echinospora (P294S mutant) | Descriptor: | CalS8, GLYCEROL | Authors: | Michalska, K, Bigelow, L, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-01-21 | Release date: | 2015-02-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis. J. Biol. Chem., 290, 2015
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3PKP
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![BU of 3pkp by Molmil](/molmil-images/mine/3pkp) | Q83S Variant of S. Enterica RmlA with dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Glucose-1-phosphate thymidylyltransferase, MAGNESIUM ION | Authors: | Chang, A, Moretti, R, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2010-11-11 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution. J.Biol.Chem., 286, 2011
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1IIN
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![BU of 1iin by Molmil](/molmil-images/mine/1iin) | thymidylyltransferase complexed with UDP-glucose | Descriptor: | URIDINE-5'-DIPHOSPHATE-GLUCOSE, glucose-1-phosphate thymidylyltransferase | Authors: | Barton, W.A, Lesniak, J, Biggins, J.B, Jeffrey, P.D, Jiang, J, Rajashankar, K.R, Thorson, J.S, Nikolov, D.B. | Deposit date: | 2001-04-23 | Release date: | 2001-05-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization. Nat.Struct.Biol., 8, 2001
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1EG6
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![BU of 1eg6 by Molmil](/molmil-images/mine/1eg6) | CRYSTAL STRUCTURE ANALYSIS OF D(CG(5-BRU)ACG) COMPLEXES TO A PHENAZINE | Descriptor: | 5'-D(*CP*GP*(BRO)UP*AP*CP*G)-3', 9-BROMO-PHENAZINE-1-CARBOXYLIC ACID (2-DIMETHYLAMINO-ETHYL)-AMIDE, BROMIDE ION, ... | Authors: | Cardin, C.J, Denny, W.A, Hobbs, J.R, Thorpe, J.H. | Deposit date: | 2000-02-14 | Release date: | 2001-01-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Guanine specific binding at a DNA junction formed by d[CG(5-BrU)ACG](2) with a topoisomerase poison in the presence of Co(2+) ions. Biochemistry, 39, 2000
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5JR3
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![BU of 5jr3 by Molmil](/molmil-images/mine/5jr3) | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone | Descriptor: | 7-hydroxy-4-methyl-2H-chromen-2-one, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Wang, F, Johnson, B.R, Huber, T.D, Singh, S, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2016-05-05 | Release date: | 2016-06-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone (to be published) To Be Published
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1ZXF
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![BU of 1zxf by Molmil](/molmil-images/mine/1zxf) | Solution structure of a self-sacrificing resistance protein, CalC from Micromonospora echinospora | Descriptor: | CalC | Authors: | Singh, S, Hager, M.H, Zhang, C, Griffith, B.R, Lee, M.S, Hallenga, K, Markley, J.L, Thorson, J.S, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2005-06-08 | Release date: | 2005-12-13 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural insight into the self-sacrifice mechanism of enediyne resistance. Acs Chem.Biol., 1, 2006
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4K0B
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![BU of 4k0b by Molmil](/molmil-images/mine/4k0b) | Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus complexed with SAM and PPi | Descriptor: | DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Wang, F, Hurley, K.A, Helmich, K.E, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2013-04-03 | Release date: | 2013-05-01 | Last modified: | 2014-10-08 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. Febs J., 281, 2014
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1MP5
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![BU of 1mp5 by Molmil](/molmil-images/mine/1mp5) | Y177F VARIANT OF S. ENTERICA RmlA | Descriptor: | URIDINE-5'-DIPHOSPHATE-GLUCOSE, Y177F VARIANT OF S. ENTERICA RmlA BOUND TO UDP-GLUCOSE | Authors: | Barton, W.A, Biggins, J.B, Jiang, J, Thorson, J.S, Nikolov, D.B. | Deposit date: | 2002-09-11 | Release date: | 2002-10-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering Proc.Natl.Acad.Sci.USA, 99, 2002
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3TOS
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![BU of 3tos by Molmil](/molmil-images/mine/3tos) | Crystal Structure of CalS11, Calicheamicin Methyltransferase | Descriptor: | 1,2-ETHANEDIOL, CalS11, GLUTAMIC ACID, ... | Authors: | Chang, A, Aceti, D.J, Beebe, E.T, Makino, S.-I, Wrobel, R.L, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2011-09-06 | Release date: | 2011-10-05 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal Structure of CalS11, Calicheamicin methyltransferase To be Published
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4L2Z
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![BU of 4l2z by Molmil](/molmil-images/mine/4l2z) | Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus complexed with SAE and PPi | Descriptor: | DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Wang, F, Hurley, K.A, Helmich, K.E, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2013-06-05 | Release date: | 2013-06-19 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.494 Å) | Cite: | Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. Febs J., 281, 2014
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1QZL
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![BU of 1qzl by Molmil](/molmil-images/mine/1qzl) | GCATGCT + Cobalt | Descriptor: | 5'-D(*GP*CP*AP*TP*GP*CP*T)-3', COBALT (II) ION | Authors: | Cardin, C.J, Gan, Y, Thorpe, J.H, Teixeira, S.C.M, Gale, B.C, Moraes, M.I.A. | Deposit date: | 2003-09-17 | Release date: | 2003-10-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Metal Ion Distribution and Stabilisation of the DNA Quadruplex Structure Formed by d(GCATGCT) To be published
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4XQ2
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![BU of 4xq2 by Molmil](/molmil-images/mine/4xq2) | Ensemble refinement of cystathione gamma lyase (CalE6) D7G from Micromonospora echinospora | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, CalE6, ... | Authors: | Wang, F, Yennamalli, R.M, Singh, S, Tan, K, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-01-18 | Release date: | 2015-04-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora To Be Published
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4XAU
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![BU of 4xau by Molmil](/molmil-images/mine/4xau) | Crystal structure of AtS13 from Actinomadura melliaura | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Putative aminotransferase | Authors: | Wang, F, Singh, S, Xu, W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2014-12-15 | Release date: | 2014-12-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.0012 Å) | Cite: | Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis. Proteins, 83, 2015
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6UVQ
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![BU of 6uvq by Molmil](/molmil-images/mine/6uvq) | Crystal structure of Apo AtmM | Descriptor: | ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION | Authors: | Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N. | Deposit date: | 2019-11-04 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structure of Apo AtmM To Be Published
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1QYK
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![BU of 1qyk by Molmil](/molmil-images/mine/1qyk) | GCATGCT + Barium | Descriptor: | 5'-D(*GP*CP*AP*TP*GP*CP*T)-3', BARIUM ION | Authors: | Cardin, C.J, Gan, Y, Thorpe, J.H, Teixeira, S.C.M, Gale, B.C, Moraes, M.I.A. | Deposit date: | 2003-09-11 | Release date: | 2003-10-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Metal Ion Distribution and Stabilization of the DNA Quadruplex Structure Formed by d(GCATGCT) To be published
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1QYL
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![BU of 1qyl by Molmil](/molmil-images/mine/1qyl) | GCATGCT + Vanadium | Descriptor: | 5'-D(*GP*CP*AP*TP*GP*CP*T)-3', VANADIUM ION | Authors: | Cardin, C.J, Gan, Y, Thorpe, J.H, Teixeira, S.C.M, Gale, B.C, Moraes, M.I.A. | Deposit date: | 2003-09-11 | Release date: | 2003-10-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Metal Ion Distribution and Stabilisation of the DNA Quadruplex Structure Formed by d(GCATGCT) To be Published
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6UWD
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![BU of 6uwd by Molmil](/molmil-images/mine/6uwd) | Crystal structure of Apo AtmM | Descriptor: | ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION | Authors: | Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N. | Deposit date: | 2019-11-05 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structure of Apo AtmM To Be Published
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1R2O
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![BU of 1r2o by Molmil](/molmil-images/mine/1r2o) | d(GCATGCT) + Ni2+ | Descriptor: | 5'-D(*GP*CP*AP*TP*GP*CP*T)-3', NICKEL (II) ION | Authors: | Cardin, J.C, Gan, Y, Thorpe, J.H, Teixeira, S.C.M, Gale, B.C, Moraes, M.I.A. | Deposit date: | 2003-09-29 | Release date: | 2003-10-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Metal Ion Distribution and Stabilization of the DNA Quadruplex Structure Formed by d(GCATGCT) To be published
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3PKQ
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![BU of 3pkq by Molmil](/molmil-images/mine/3pkq) | Q83D Variant of S. Enterica RmlA with dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, Glucose-1-phosphate thymidylyltransferase, ... | Authors: | Chang, A, Moretti, R, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2010-11-11 | Release date: | 2011-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution. J.Biol.Chem., 286, 2011
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2LUZ
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![BU of 2luz by Molmil](/molmil-images/mine/2luz) | Solution NMR Structure of CalU16 from Micromonospora echinospora, Northeast Structural Genomics Consortium (NESG) Target MiR12 | Descriptor: | CalU16 | Authors: | Ramelot, T.A, Yang, Y, Lee, H, Pederson, K, Lee, D, Kohan, E, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Wrobel, R.L, Bingman, C.A, Singh, S, Thorson, J.S, Prestegard, J.H, Montelione, G.T, Phillips Jr, G.N, Kennedy, M.A, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-06-22 | Release date: | 2012-10-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19. Acs Chem.Biol., 9, 2014
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1M69
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![BU of 1m69 by Molmil](/molmil-images/mine/1m69) | |