4XRR

Crystal structure of cals8 from micromonospora echinospora (P294S mutant)

Replaces:  4WB1

Summary for 4XRR

• Entry DOI: 10.2210/pdb4xrr/pdb
• Descriptor: CalS8, GLYCEROL (3 entities in total)
• Functional Keywords: calicheamicin, oxidoreductase, structural genomics, psi-biology, midwest center for structural genomics, mcsg, enzyme discovery for natural product biosynthesis, natpro
• Biological source: Micromonospora echinospora
• Total number of polymer chains: 2
• Total formula weight: 96175.68

Authors

Michalska, K.,Bigelow, L.,Endres, M.,Babnigg, G.,Bingman, C.A.,Yennamalli, R.M.,Singh, S.,Kharel, M.K.,Thorson, J.S.,Phillips Jr., G.N.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG),Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2015-01-21, release date: 2015-02-11, Last modification date: 2023-11-15)

• Primary citation: Singh, S.,Michalska, K.,Bigelow, L.,Endres, M.,Kharel, M.K.,Babnigg, G.,Yennamalli, R.M.,Bingman, C.A.,Joachimiak, A.,Thorson, J.S.,Phillips, G.N.; Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.; J. Biol. Chem., 290:26249-26258, 2015; PubMed: 26240141; DOI: 10.1074/jbc.M115.673459

Experimental method

X-RAY DIFFRACTION (2.55 Å)