7W47
 
 | | Crystal structure of the gastric proton pump complexed with tegoprazan | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Potassium-transporting ATPase alpha chain 1, ... | | 著者 | Abe, K, Tanaka, S, Morita, M, Yamagishi, T. | | 登録日 | 2021-11-26 | | 公開日 | 2022-01-05 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
J.Med.Chem., 65, 2022
|
|
7W48
 | |
7W49
 | |
7W4A
 | | Cryo-EM structure of the gastric proton pump complexed with revaprazan | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | | 著者 | Abe, K, Tanaka, S, Morita, M, Yamagishi, T. | | 登録日 | 2021-11-26 | | 公開日 | 2022-03-02 | | 最終更新日 | 2022-07-20 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
J.Med.Chem., 65, 2022
|
|
7OEX
 | |
6KSL
 | | Staphylococcus aureus lipase - S116A inactive mutant | | 分子名称: | CALCIUM ION, LAURIC ACID, Lipase 2, ... | | 著者 | Kitadokoro, K, Tanaka, M, Kamitani, S. | | 登録日 | 2019-08-24 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat.
Sci Rep, 10, 2020
|
|
6KSM
 | | Staphylococcus aureus lipase -Orlistat complex | | 分子名称: | (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID, CALCIUM ION, LAURIC ACID, ... | | 著者 | Kitadokoro, K, Tanaka, M, Kamitani, S. | | 登録日 | 2019-08-24 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat.
Sci Rep, 10, 2020
|
|
6KSI
 | | Staphylococcus aureus lipase - native | | 分子名称: | CALCIUM ION, HEXANOIC ACID, LAURIC ACID, ... | | 著者 | Kitadokoro, K, Tanaka, M, Kamitani, S. | | 登録日 | 2019-08-24 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat.
Sci Rep, 10, 2020
|
|
5IJA
 | |
8H3M
 | | Conformation 1 of SARS-CoV-2 Omicron BA.1 Variant Spike protein complexed with MO1 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MO1 heavy chain, Spike glycoprotein | | 著者 | Ishimaru, H, Nishimura, M, Sutandhio, S, Shigematsu, H, Kato, K, Hasegawa, N, Mori, Y. | | 登録日 | 2022-10-09 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | | 主引用文献 | Identification and Analysis of Monoclonal Antibodies with Neutralizing Activity against Diverse SARS-CoV-2 Variants.
J.Virol., 97, 2023
|
|
8H3N
 | | Conformation 2 of SARS-CoV-2 Omicron BA.1 Variant Spike protein complexed with MO1 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MO1 heavy-chain, MO1 light chain, ... | | 著者 | Ishimaru, H, Nishimura, M, Sutandhio, S, Shigematsu, H, Kato, K, Hasegawa, N, Mori, Y. | | 登録日 | 2022-10-09 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Identification and Analysis of Monoclonal Antibodies with Neutralizing Activity against Diverse SARS-CoV-2 Variants.
J.Virol., 97, 2023
|
|
8J7W
 | | Cryo-EM structure of hZnT7-Fab complex in zinc state 2, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-bound conformation | | 分子名称: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, ZINC ION, ... | | 著者 | Han, B.B, Inaba, K, Watanabe, S. | | 登録日 | 2023-04-28 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
Nat Commun, 14, 2023
|
|
8J7X
 | | Cryo-EM structure of hZnT7DeltaHis-loop-Fab complex in zinc-unbound state, determined in outward-facing conformation | | 分子名称: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, Zinc transporter 7 | | 著者 | Han, B.B, Inaba, K, Watanabe, S. | | 登録日 | 2023-04-28 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
Nat Commun, 14, 2023
|
|
8J7V
 | | Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation | | 分子名称: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, Zinc transporter 7 | | 著者 | Han, B.B, Inaba, K, Watanabe, S. | | 登録日 | 2023-04-28 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
Nat Commun, 14, 2023
|
|
8J7U
 | | Cryo-EM structure of hZnT7-Fab complex in zinc-bound state, determined in outward-facing conformation | | 分子名称: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, ZINC ION, ... | | 著者 | Han, B.B, Inaba, K, Watanabe, S. | | 登録日 | 2023-04-28 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
Nat Commun, 14, 2023
|
|
8J80
 | | Cryo-EM structure of hZnT7-Fab complex in zinc state 1, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-unbound conformation | | 分子名称: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, ZINC ION, ... | | 著者 | Han, B.B, Inaba, K, Watanabe, S. | | 登録日 | 2023-04-28 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
Nat Commun, 14, 2023
|
|
8J7T
 | | Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in outward-facing conformation | | 分子名称: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, Zinc transporter 7 | | 著者 | Han, B.B, Inaba, K, Watanabe, S. | | 登録日 | 2023-04-28 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
Nat Commun, 14, 2023
|
|
8J7Y
 | | Cryo-EM structure of hZnT7DeltaHis-loop-Fab complex in zinc-bound state, determined in outward-facing conformation | | 分子名称: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, ZINC ION, ... | | 著者 | Han, B.B, Inaba, K, Watanabe, S. | | 登録日 | 2023-04-28 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
Nat Commun, 14, 2023
|
|
7Q8T
 | | Crystal structure of NAMPT bound to ligand TSY535(compound 9a) | | 分子名称: | Nicotinamide phosphoribosyltransferase, SULFATE ION, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate | | 著者 | Kraemer, A, Tang, S, Butterworth, S, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2021-11-11 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.
Acta Pharm Sin B, 13, 2023
|
|
2E29
 | | Solution structure of the GUCT domain from human ATP-dependent RNA helicase DDX50, DEAD box protein 50 | | 分子名称: | ATP-dependent RNA helicase DDX50 | | 著者 | Ohnishi, S, Paakkonen, K, Guntert, P, Sato, M, Koshiba, S, Harada, T, Watanabe, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-11-10 | | 公開日 | 2007-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the GUCT domain from human RNA helicase II/Gubeta reveals the RRM fold, but implausible RNA interactions
Proteins, 74, 2008
|
|
3JCX
 | | Canine Parvovirus complexed with Fab E | | 分子名称: | Capsid protein 2, Fab E heavy chain, Fab E light chain | | 著者 | Organtini, L.J, Iketani, S, Huang, K, Ashley, R.E, Makhov, A.M, Conway, J.F, Parrish, C.R, Hafenstein, S. | | 登録日 | 2016-03-21 | | 公開日 | 2016-07-20 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus.
J.Virol., 90, 2016
|
|
8K7Q
 | | Staphylococcus aureus lipase S116A inactive mutant-PSA complex | | 分子名称: | ACETIC ACID, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Kitadokoro, J, Kamitani, S, Kitadokoro, K. | | 登録日 | 2023-07-27 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Crystal structure of Staphylococcus aureus lipase complex with unsaturated petroselinic acid.
Febs Open Bio, 14, 2024
|
|
8K7P
 | | Staphylococcus aureus lipase -PSA complex | | 分子名称: | ACETIC ACID, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Kitadokoro, J, Kamitani, S, Kitadokoro, K. | | 登録日 | 2023-07-27 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Crystal structure of Staphylococcus aureus lipase complex with unsaturated petroselinic acid.
Febs Open Bio, 14, 2024
|
|
5MTF
 | | A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases | | 分子名称: | CHLORIDE ION, Rhomboid protease GlpG, inhibitor, ... | | 著者 | Ticha, A, Stanchev, S, Vinothkumar, K.R, Mikles, D.C, Pachl, P, Svehlova, K, Nguyen, M.T.N, Verhelst, S.H.L, Johnson, D, Bachovchin, D, Lepsik, M, Majer, P, Strisovsky, K. | | 登録日 | 2017-01-09 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Cell Chem Biol, 24, 2017
|
|
2ZWP
 | | Crystal structure of Ca3 site mutant of Pro-S324A | | 分子名称: | CALCIUM ION, Tk-subtilisin | | 著者 | Takeuchi, Y, Tanaka, S, Matsumura, H, Koga, Y, Takano, K, Kanaya, S. | | 登録日 | 2008-12-17 | | 公開日 | 2009-06-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Requirement of a unique Ca(2+)-binding loop for folding of Tk-subtilisin from a hyperthermophilic archaeon.
Biochemistry, 48, 2009
|
|
