8J7V

Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation

Summary for 8J7V

• Entry DOI: 10.2210/pdb8j7v/pdb
• EMDB information: 36050
• Descriptor: Zinc transporter 7, Light chain of YN7114-08 Fab, Heavy chain of YN7114-08 Fab (3 entities in total)
• Functional Keywords: zinc, proton, transporter, golgi apparatus, metal transporter, histidine-rich loop, metal transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 184237.90

Authors

Han, B.B.,Inaba, K.,Watanabe, S. (deposition date: 2023-04-28, release date: 2023-09-20)

• Primary citation: Bui, H.B.,Watanabe, S.,Nomura, N.,Liu, K.,Uemura, T.,Inoue, M.,Tsutsumi, A.,Fujita, H.,Kinoshita, K.,Kato, Y.,Iwata, S.,Kikkawa, M.,Inaba, K.; Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.; Nat Commun, 14:4770-4770, 2023; PubMed: 37553324; DOI: 10.1038/s41467-023-40521-5

Experimental method

ELECTRON MICROSCOPY (2.79 Å)