316D
 
 | | Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity | | Descriptor: | 8-FLUORO-ACTINOMYCIN D, DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3') | | Authors: | Takusagawa, F, Takusagawa, K.T, Carlson, R.G, Weaver, R.F. | | Deposit date: | 1997-03-05 | | Release date: | 1997-11-05 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Selectivity of F8-Actinomycin D for RNA:DNA Hybrids and its Anti-Leukemia Activity.
Bioorg.Med.Chem., 5, 1997
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5ANA
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2PBJ
 | | GSH-heme bound microsomal prostaglandin E synthase | | Descriptor: | CHLORIDE ION, GLUTATHIONE, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Takusagawa, F, Yamada, T. | | Deposit date: | 2007-03-28 | | Release date: | 2008-02-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
Biochemistry, 46, 2007
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1KHH
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1KIA
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1K0U
 | | Inhibition of S-adenosylhomocysteine Hydrolase by "acyclic sugar" Adenosine Analogue D-eritadenine | | Descriptor: | D-ERITADENINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE | | Authors: | Takusagawa, F, Huang, Y, Komoto, J, Takata, Y, Gomi, T, Ogawa, H, Fujioka, M, Powell, D. | | Deposit date: | 2001-09-20 | | Release date: | 2001-10-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
J.Biol.Chem., 277, 2002
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1MXB
 | | S-ADENOSYLMETHIONINE SYNTHETASE WITH ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Takusagawa, F, Kamitori, S, Markham, G.D. | | Deposit date: | 1996-01-10 | | Release date: | 1996-07-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
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1MXA
 | | S-ADENOSYLMETHIONINE SYNTHETASE WITH PPI | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | Takusagawa, F, Kamitori, S, Markham, G.D. | | Deposit date: | 1996-01-10 | | Release date: | 1996-07-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
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1MXC
 | | S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP | | Descriptor: | 8-BROMOADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Takusagawa, F, Kamitori, S, Markham, G.D. | | Deposit date: | 1996-01-10 | | Release date: | 1996-07-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
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1P7L
 | | S-Adenosylmethionine synthetase complexed with AMPPNP and Met. | | Descriptor: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, METHIONINE, ... | | Authors: | Takusagawa, F, Komoto, J. | | Deposit date: | 2003-05-02 | | Release date: | 2004-03-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the s-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET.
Biochemistry, 43, 2004
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1XRC
 | | CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE | | Descriptor: | COBALT (II) ION, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D. | | Deposit date: | 1995-10-26 | | Release date: | 1996-03-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
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1XRA
 | | CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D. | | Deposit date: | 1995-10-26 | | Release date: | 1996-03-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
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1XRB
 | | S-adenosylmethionine synthetase (MAT, ATP: L-methionine S-adenosyltransferase, E.C.2.5.1.6) in which MET residues are replaced with selenomethionine residues (MSE) | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D. | | Deposit date: | 1995-10-26 | | Release date: | 1996-03-08 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
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209D
 | | Structural, physical and biological characteristics of RNA:DNA binding agent N8-actinomycin D | | Descriptor: | DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3'), N8-ACTINOMYCIN D | | Authors: | Shinomiya, M, Chu, W, Carlson, R.G, Weaver, R.F, Takusagawa, F. | | Deposit date: | 1995-05-01 | | Release date: | 1995-10-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural, Physical, and Biological Characteristics of RNA.DNA Binding Agent N8-Actinomycin D.
Biochemistry, 34, 1995
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2RKB
 | | Serine dehydratase like-1 from human cancer cells | | Descriptor: | POTASSIUM ION, PYRIDOXAL-5'-PHOSPHATE, Serine dehydratase-like | | Authors: | Yamada, T, Komoto, J, Kasuya, T, Mori, H, Ogawa, H, Takusagawa, F. | | Deposit date: | 2007-10-16 | | Release date: | 2008-04-01 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: Crystal structure and site-directed mutagenesis studies.
Biochim.Biophys.Acta, 1780, 2008
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1KY4
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1KY5
 | | D244E mutant S-Adenosylhomocysteine hydrolase refined with noncrystallographic restraints | | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3'-OXO-ADENOSINE, S-adenosylhomocysteine hydrolase | | Authors: | Takata, Y, Takusagawa, F. | | Deposit date: | 2002-02-03 | | Release date: | 2002-09-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Catalytic Mechanism of S-adenosylhomocysteine hydrolase. Site-directed
mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
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2D55
 | | Structural, physical and biological characteristics of RNA.DNA binding agent N8-actinomycin D | | Descriptor: | ACTINOMYCIN D, DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3') | | Authors: | Shinomiya, M, Chu, W, Carlson, R.G, Weaver, R.F, Takusagawa, F. | | Deposit date: | 1995-05-01 | | Release date: | 1995-10-15 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure of the 2:1 Complex between D(Gaagcttc) and the Anticancer Drug Actinomycin D.
J.Mol.Biol., 225, 1992
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2H5L
 | | S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine | | Descriptor: | (2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC ACID, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Yamada, T, Komoto, J, Takusagawa, F. | | Deposit date: | 2006-05-26 | | Release date: | 2007-04-10 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.
Biochem.Pharm., 73, 2007
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1FUG
 | | S-ADENOSYLMETHIONINE SYNTHETASE | | Descriptor: | S-ADENOSYLMETHIONINE SYNTHETASE | | Authors: | Fu, Z, Markham, G.D, Takusagawa, F. | | Deposit date: | 1996-02-25 | | Release date: | 1996-08-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Flexible loop in the structure of S-adenosylmethionine synthetase crystallized in the tetragonal modification.
J.Biomol.Struct.Dyn., 13, 1996
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2F38
 | | Crystal structure of prostaglandin F synathase containing bimatoprost | | Descriptor: | (5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Komoto, J, Yamada, T, Watanabe, K, Woodward, D.F, Takusagawa, F. | | Deposit date: | 2005-11-18 | | Release date: | 2006-10-31 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost.
Biochemistry, 45, 2006
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1RY0
 | | Structure of prostaglandin F synthase with prostaglandin D2 | | Descriptor: | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROSTAGLANDIN D2 | | Authors: | Komoto, J, Yamada, T, Watanabe, K, Takusagawa, F. | | Deposit date: | 2003-12-19 | | Release date: | 2004-11-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Crystal structure of human prostaglandin F synthase (AKR1C3).
Biochemistry, 43, 2004
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1RY8
 | | Prostaglandin F synthase complexed with NADPH and rutin | | Descriptor: | Aldo-keto reductase family 1 member C3, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RUTIN | | Authors: | Komoto, J, Yamada, T, Watanabe, K, Takusagawa, F. | | Deposit date: | 2003-12-19 | | Release date: | 2004-11-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Crystal structure of human prostaglandin F synthase (AKR1C3).
Biochemistry, 43, 2004
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1RG9
 | | S-Adenosylmethionine synthetase complexed with SAM and PPNP | | Descriptor: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Komoto, J, Yamada, T, Takata, Y, Markham, G.D, Takusagawa, F. | | Deposit date: | 2003-11-11 | | Release date: | 2004-03-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET.
Biochemistry, 43, 2004
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1D2C
 | | METHYLTRANSFERASE | | Descriptor: | PROTEIN (GLYCINE N-METHYLTRANSFERASE) | | Authors: | Huang, Y, Takusagawa, F. | | Deposit date: | 1999-09-23 | | Release date: | 1999-10-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
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