2H5L

S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine

Summary for 2H5L

Entry DOI	10.2210/pdb2h5l/pdb
Descriptor	Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC ACID, ... (4 entities in total)
Functional Keywords	s-adenosylhomocysteine, hydrolase, inhibitor, hypocholesterolemic activity
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Cytoplasm: P10760
Total number of polymer chains	8
Total formula weight	387050.90
Authors	Yamada, T.,Komoto, J.,Takusagawa, F. (deposition date: 2006-05-26, release date: 2007-04-10, Last modification date: 2024-02-14)
Primary citation	Yamada, T.,Komoto, J.,Lou, K.,Ueki, A.,Hua, D.H.,Sugiyama, K.,Takata, Y.,Ogawa, H.,Takusagawa, F. Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochem.Pharm., 73:981-989, 2007 Cited by PubMed: 17214973 DOI: 10.1016/j.bcp.2006.12.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation