1K0U

Inhibition of S-adenosylhomocysteine Hydrolase by "acyclic sugar" Adenosine Analogue D-eritadenine

Replaces:  1D4G

Summary for 1K0U

• Entry DOI: 10.2210/pdb1k0u/pdb
• Related: 1D4G
• Descriptor: S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, D-ERITADENINE, ... (4 entities in total)
• Functional Keywords: s-adenosylhomocysteine, hydrolase, d-eritadenine, inhibitor
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Cytoplasm: P10760
• Total number of polymer chains: 8
• Total formula weight: 387058.81

Authors

Takusagawa, F.,Huang, Y.,Komoto, J.,Takata, Y.,Gomi, T.,Ogawa, H.,Fujioka, M.,Powell, D. (deposition date: 2001-09-20, release date: 2001-10-17, Last modification date: 2023-08-16)

• Primary citation: Huang, Y.,Komoto, J.,Takata, Y.,Powell, D.R.,Gomi, T.,Ogawa, H.,Fujioka, M.,Takusagawa, F.; Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.; J.Biol.Chem., 277:7477-7482, 2002; PubMed: 11741948; DOI: 10.1074/jbc.M109187200

Experimental method

X-RAY DIFFRACTION (3 Å)