6QZT
 
 | |
6R9R
 | | Crystal structure of Csx1 in complex with cyclic oligoadenylate cOA4 conformation 2 | | Descriptor: | CRISPR-associated (Cas) DxTHG family, circular RNA (5'-R(P*AP*AP*AP*A)-3') | | Authors: | Molina, R, Montoya, G, Sofos, N, Stella, S. | | Deposit date: | 2019-04-03 | | Release date: | 2019-10-02 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of Csx1-cOA4complex reveals the basis of RNA decay in Type III-B CRISPR-Cas.
Nat Commun, 10, 2019
|
|
6R7B
 | | Crystal structure of Csx1 in complex with cyclic oligoadenylate cOA4 conformation 1 | | Descriptor: | CRISPR-associated (Cas) DxTHG family, RNA (5'-R(P*AP*AP*AP*A)-3') | | Authors: | Molina, R, Montoya, G, Sofos, N, Stella, S. | | Deposit date: | 2019-03-28 | | Release date: | 2019-10-02 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.12 Å) | | Cite: | Structure of Csx1-cOA4complex reveals the basis of RNA decay in Type III-B CRISPR-Cas.
Nat Commun, 10, 2019
|
|
6S6B
 | | Type III-B Cmr-beta Cryo-EM structure of the Apo state | | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | Authors: | Sofos, N, Montoya, G, Stella, S. | | Deposit date: | 2019-07-02 | | Release date: | 2020-07-08 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
|
|
6S8B
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1 | | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | Authors: | Sofos, N, Montoya, G, Stella, S. | | Deposit date: | 2019-07-09 | | Release date: | 2020-07-08 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
|
|
6S91
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2 | | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | Authors: | Sofos, N, Montoya, G, Stella, S. | | Deposit date: | 2019-07-11 | | Release date: | 2020-07-08 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
|
|
6SIC
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA | | Descriptor: | CRISPR-associated RAMP protein, Cmr1 family, Cmr4 family, ... | | Authors: | Sofos, N, Montoya, G, Stella, S. | | Deposit date: | 2019-08-09 | | Release date: | 2020-07-08 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
|
|
6S8E
 | | Cryo-EM structure of the type III-B Cmr-beta complex bound to non-cognate target RNA | | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | Authors: | Sofos, N, Montoya, G, Stella, S. | | Deposit date: | 2019-07-09 | | Release date: | 2020-07-08 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
|
|
6SH8
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2, in the presence of ssDNA | | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | Authors: | Sofos, N, Montoya, G, Stella, S. | | Deposit date: | 2019-08-06 | | Release date: | 2020-07-08 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
|
|
6SHB
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1, in the presence of ssDNA | | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | Authors: | Sofos, N, Montoya, G, Stella, S. | | Deposit date: | 2019-08-06 | | Release date: | 2020-07-08 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
|
|
4AAF
 | | Crystal structure of the mutant D75N I-CreI in complex with an altered target (The four central bases, 2NN region, are composed by TGCA from 5' to 3') | | Descriptor: | 1,2-ETHANEDIOL, 24MER DNA, DNA ENDONUCLEASE I-CREI | | Authors: | Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. | | Deposit date: | 2011-12-01 | | Release date: | 2012-05-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
|
|
4AAB
 | | Crystal structure of the mutant D75N I-CreI in complex with its wild- type target (The four central bases, 2NN region, are composed by GTAC from 5' to 3') | | Descriptor: | 10MER DNA 5'-D(*GP*AP*CP*GP*TP*TP*TP*TP*GP*AP)-3', 14MER DNA 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP)-3', DNA ENDONUCLEASE I-CREI, ... | | Authors: | Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. | | Deposit date: | 2011-12-01 | | Release date: | 2012-05-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
|
|
4AAE
 | | Crystal structure of the mutant D75N I-CreI in complex with an altered target (The four central bases, 2NN region, are composed by AGCG from 5' to 3') | | Descriptor: | 24MER DNA, DNA ENDONUCLEASE I-CREI | | Authors: | Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. | | Deposit date: | 2011-12-01 | | Release date: | 2012-05-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
|
|
4AAG
 | | Crystal structure of the mutant D75N I-CreI in complex with its wild- type target in presence of Ca at the active site (The four central bases, 2NN region, are composed by GTAC from 5' to 3') | | Descriptor: | 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP *GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', CALCIUM ION, DNA ENDONUCLEASE I-CREI | | Authors: | Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. | | Deposit date: | 2011-12-01 | | Release date: | 2012-05-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
|
|
4AAD
 | | Crystal structure of the mutant D75N I-CreI in complex with its wild- type target in absence of metal ions at the active site (The four central bases, 2NN region, are composed by GTAC from 5' to 3') | | Descriptor: | 24MER DNA, DNA ENDONUCLEASE I-CREI, GLYCEROL | | Authors: | Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. | | Deposit date: | 2011-12-01 | | Release date: | 2012-05-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
|
|
6GTE
 | | Transient state structure of CRISPR-Cpf1 (Cas12a) I3 conformation | | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*AP*G)-3'), ... | | Authors: | Montoya, G, Mesa, P, Stella, S. | | Deposit date: | 2018-06-18 | | Release date: | 2018-12-19 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell, 175, 2018
|
|
6GTG
 | | Transition state structure of Cpf1(Cas12a) I4 conformation | | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (32-MER), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*AP*GP*T)-3'), ... | | Authors: | Mesa, P, Montoya, G, Stella, S. | | Deposit date: | 2018-06-18 | | Release date: | 2018-12-19 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell, 175, 2018
|
|
6GTF
 | | Transient state structure of CRISPR-Cpf1 (Cas12a) I5 conformation | | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*A)-3'), ... | | Authors: | Montoya, G, Mesa, P, Stella, S. | | Deposit date: | 2018-06-18 | | Release date: | 2018-12-19 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.63 Å) | | Cite: | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell, 175, 2018
|
|
7PQ6
 | | Crystal Structure of the Ring Nuclease 0811 mutant-S12A from Sulfolobus islandicus (Sis0811) | | Descriptor: | CRISPR-associated protein, APE2256 family | | Authors: | Molina, R, Jensen, A.L.G, Marchena-Hurtado, J, Lopez-Mendez, B, Stella, S, Montoya, G. | | Deposit date: | 2021-09-16 | | Release date: | 2021-11-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.
Nucleic Acids Res., 49, 2021
|
|
7PQ3
 | | Crystal Structure of the Ring Nuclease 0811 from Sulfolobus islandicus (Sis0811) in complex with its post-catalytic reaction product | | Descriptor: | 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, CRISPR-associated protein, APE2256 family | | Authors: | Molina, R, Jensen, A.L.G, Marchena-Hurtado, J, Lopez-Mendez, B, Stella, S, Montoya, G. | | Deposit date: | 2021-09-16 | | Release date: | 2021-11-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.
Nucleic Acids Res., 49, 2021
|
|
7PQ2
 | | Crystal Structure of the Ring Nuclease 0811 from Sulfolobus islandicus (Sis0811) in its apo form | | Descriptor: | CRISPR-associated protein, APE2256 family, CRISPR Ring Nuclease | | Authors: | Molina, R, Jensen, A.L.G, Marchena-Hurtado, J, Lopez-Mendez, B, Stella, S, Montoya, G. | | Deposit date: | 2021-09-16 | | Release date: | 2021-11-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.
Nucleic Acids Res., 49, 2021
|
|
7PQA
 | | Crystal Structure of the Ring Nuclease 0811 mutant-S12G/K169G from Sulfolobus islandicus (Sis0811) | | Descriptor: | CRISPR-associated protein, APE2256 family | | Authors: | Molina, R, Jensen, A.L.G, Marchena-Hurtado, J, Lopez-Mendez, B, Stella, S, Montoya, G. | | Deposit date: | 2021-09-16 | | Release date: | 2021-12-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.
Nucleic Acids Res., 49, 2021
|
|
7Z56
 | | Crystal Structure of the Ring Nuclease 0455 from Sulfolobus islandicus (Sis0455) in its apo form | | Descriptor: | CRISPR-associated protein | | Authors: | Molina, R, Martin-Garcia, R, Lopez-Mendez, B, Jensen, A.L.G, Marchena-Hurtado, J, Stella, S, Montoya, G. | | Deposit date: | 2022-03-08 | | Release date: | 2022-11-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases.
Nucleic Acids Res., 50, 2022
|
|
7Z55
 | | Crystal Structure of the Ring Nuclease 0455 from Sulfolobus islandicus (Sis0455) in complex with its substrate | | Descriptor: | ACETATE ION, CRISPR-associated protein, Cyclic RNA cA4, ... | | Authors: | Molina, R, Martin-Garcia, R, Lopez-Mendez, B, Jensen, A.L.G, Marchena-Hurtado, J, Stella, S, Montoya, G. | | Deposit date: | 2022-03-08 | | Release date: | 2022-11-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.664 Å) | | Cite: | Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases.
Nucleic Acids Res., 50, 2022
|
|
8AA5
 | | Cryo-EM structure of the strand transfer complex of the TnsB transposase (type V-K CRISPR-associated transposon) | | Descriptor: | LE_PolyA, LE_Target, RE_PolyA, ... | | Authors: | Tenjo-Castano, F, Sofos, N, Lopez-Mendez, B, Stutzke, L.S, Fuglsang, A, Stella, S, Montoya, G. | | Deposit date: | 2022-06-30 | | Release date: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (2.46 Å) | | Cite: | Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon.
Nat Commun, 13, 2022
|
|
