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PDB: 119 件
6E5B
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Human Immunoproteasome 20S particle in complex with compound 1
分子名称: Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ...
著者Steinbacher, S, Augustin, M, Blaesse, M, Harris, S.F.
登録日2018-07-19
公開日2019-09-11
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability.
J.Med.Chem., 62, 2019
5IX0
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HDAC2 WITH LIGAND BRD7232
分子名称: (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ...
著者Steinbacher, S.
登録日2016-03-23
公開日2016-08-31
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg.Med.Chem., 24, 2016
5IWG
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HDAC2 WITH LIGAND BRD4884
分子名称: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Steinbacher, S.
登録日2016-03-22
公開日2016-08-31
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg.Med.Chem., 24, 2016
1Z4A
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Ferritin from T. maritima
分子名称: EICOSANE, ferritin
著者Steinbacher, S, Schiffmann, S, Bacher, A, Fischer, M.
登録日2005-03-15
公開日2006-10-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of T. maritima ferritin
To be Published
8R3E
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Huntingtin, 1-17, MBP-N
分子名称: Maltodextrin-binding protein, ZINC ION
著者Steinbacher, S, Toledo-Sherman, L, Dominguez, C.
登録日2023-11-08
公開日2024-09-18
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Post-translational modifications in the first 17 amino acids of huntingtin influence self-association and interaction with membranes
To Be Published
6GK8
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Crystal structure of anti-tau antibody dmCBTAU-28.1, double mutant (S32R, E35K) of CBTAU-28.1, in complex with Tau peptide A7731 (residues 52-71)
分子名称: CHLORIDE ION, HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-28.1(S32R;E35K), TAU PEPTIDE A7731 (RESIDUES 52-71)
著者Steinbacher, S, Mrosek, M, Juraszek, J.
登録日2018-05-18
公開日2018-06-13
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6GK7
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Crystal structure of anti-tau antibody dmCBTAU-27.1, double mutant (S31Y, T100I) of CBTAU-27.1, in complex with Tau peptide A8119B (residues 299-318)
分子名称: CHLORIDE ION, HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I), HUMAN TAU PEPTIDE A8119 RESIDUES 299-318
著者Steinbacher, S, Mrosek, M, Juraszek, J.
登録日2018-05-18
公開日2018-06-13
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
1CJA
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ACTIN-FRAGMIN KINASE, CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM
分子名称: ADENOSINE MONOPHOSPHATE, PROTEIN (ACTIN-FRAGMIN KINASE)
著者Steinbacher, S, Hof, P, Eichinger, L, Schleicher, M, Gettemans, J, Vandekerckhove, J, Huber, R, Benz, J.
登録日1999-04-08
公開日1999-06-18
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.
EMBO J., 18, 1999
6XDF
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Crystal structure of IRE1a in complex with G-4100
分子名称: 4-amino-N-(6-chloro-2-fluoro-3-{[(pyrrolidin-1-yl)sulfonyl]amino}phenyl)quinazoline-8-carboxamide, SODIUM ION, Serine/threonine-protein kinase/endoribonuclease IRE1
著者Steinbacher, S, Wang, W.
登録日2020-06-10
公開日2021-04-21
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1 alpha Inhibitory Activity.
Acs Med.Chem.Lett., 11, 2020
1CLW
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TAILSPIKE PROTEIN FROM PHAGE P22, V331A MUTANT
分子名称: TAILSPIKE PROTEIN
著者Steinbacher, S, Baxa, U, Weintraub, A, Huber, R, Seckler, R.
登録日1999-05-04
公開日1999-11-05
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity.
J.Mol.Biol., 293, 1999
1TYU
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STRUCTURE OF TAILSPIKE-PROTEIN
分子名称: TAILSPIKE PROTEIN, alpha-D-galactopyranose-(1-2)-[alpha-D-Tyvelopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-alpha-L-rhamnopyranose-(1-3)-alpha-D-galactopyranose-(1-2)-[alpha-D-Tyvelopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-alpha-L-rhamnopyranose
著者Steinbacher, S, Huber, R.
登録日1996-07-26
公開日1997-07-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors.
Proc.Natl.Acad.Sci.USA, 93, 1996
1TYW
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STRUCTURE OF TAILSPIKE-PROTEIN
分子名称: TAILSPIKE PROTEIN, alpha-D-galactopyranose-(1-2)-[alpha-D-Tyvelopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-alpha-L-rhamnopyranose-(1-3)-[alpha-D-glucopyranose-(1-4)]alpha-D-galactopyranose-(1-2)-[alpha-D-Tyvelopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-alpha-L-rhamnopyranose
著者Steinbacher, S, Huber, R.
登録日1996-07-26
公開日1997-07-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors.
Proc.Natl.Acad.Sci.USA, 93, 1996
1TYX
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TITLE OF TAILSPIKE-PROTEIN
分子名称: TAILSPIKE PROTEIN, alpha-D-galactopyranose-(1-2)-[alpha-D-Abequopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-alpha-L-rhamnopyranose-(1-3)-alpha-D-galactopyranose-(1-2)-[alpha-D-Abequopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-alpha-L-rhamnopyranose
著者Steinbacher, S, Huber, R.
登録日1996-07-26
公開日1997-07-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors.
Proc.Natl.Acad.Sci.USA, 93, 1996
1TYV
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STRUCTURE OF TAILSPIKE-PROTEIN
分子名称: TAILSPIKE PROTEIN
著者Steinbacher, S, Huber, R.
登録日1996-07-26
公開日1997-07-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors.
Proc.Natl.Acad.Sci.USA, 93, 1996
1LKT
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CRYSTAL STRUCTURE OF THE HEAD-BINDING DOMAIN OF PHAGE P22 TAILSPIKE PROTEIN
分子名称: TAILSPIKE PROTEIN
著者Steinbacher, S.
登録日1997-10-17
公開日1998-01-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Phage P22 tailspike protein: crystal structure of the head-binding domain at 2.3 A, fully refined structure of the endorhamnosidase at 1.56 A resolution, and the molecular basis of O-antigen recognition and cleavage.
J.Mol.Biol., 267, 1997
1MVL
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PPC decarboxylase mutant C175S
分子名称: FLAVIN MONONUCLEOTIDE, PPC decarboxylase AtHAL3a
著者Steinbacher, S, Hernandez-Acosta, P, Bieseler, B, Blaesse, M, Huber, R, Culianez-Macia, F.A, Kupke, T.
登録日2002-09-26
公開日2003-03-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the Plant PPC Decarboxylase AtHAL3a Complexed with an Ene-thiol Reaction Intermediate
J.Mol.Biol., 327, 2003
1SNN
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3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii
分子名称: 3,4-dihydroxy-2-butanone 4-phosphate synthase, CALCIUM ION, RIBULOSE-5-PHOSPHATE, ...
著者Steinbacher, S, Schiffmann, S, Huber, R, Bacher, A, Fischer, M.
登録日2004-03-11
公開日2004-07-20
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate.
Acta Crystallogr.,Sect.D, 60, 2004
1JY8
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2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF)
分子名称: 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, ...
著者Steinbacher, S, Kaiser, J, Wungsintaweekul, J, Hecht, S, Eisenreich, W, Gerhardt, S, Bacher, A, Rohdich, F.
登録日2001-09-11
公開日2002-01-30
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.
J.Mol.Biol., 316, 2002
1MVN
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PPC decarboxylase mutant C175S complexed with pantothenoylaminoethenethiol
分子名称: 2,4-DIHYDROXY-N-[2-(2-MERCAPTO-VINYLCARBAMOYL)-ETHYL]-3,3-DIMETHYL-BUTYRAMIDE, FLAVIN MONONUCLEOTIDE, PPC decarboxylase AtHAL3a
著者Steinbacher, S, Hernandez-Acosta, P, Bieseler, B, Blaesse, M, Huber, R, Culianez-Macia, F.A, Kupke, T.
登録日2002-09-26
公開日2003-03-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal Structure of the Plant PPC Decarboxylase AtHAL3a Complexed with an Ene-thiol Reaction Intermediate
J.Mol.Biol., 327, 2003
1ONO
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IspC Mn2+ complex
分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION
著者Steinbacher, S, Kaiser, J, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F.
登録日2003-02-28
公開日2003-03-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
J.BIOL.CHEM., 278, 2003
1ONN
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IspC apo structure
分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
著者Steinbacher, S, Kaiser, J, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F.
登録日2003-02-28
公開日2003-03-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
J.BIOL.CHEM., 278, 2003
1PVW
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3,4-dihydroxy-2-butanone 4-phosphate synthase from M. jannaschii
分子名称: 3,4-dihydroxy-2-butanone 4-phosphate synthase, CALCIUM ION, PHOSPHATE ION, ...
著者Steinbacher, S, Schiffmann, S, Richter, G, Huber, R, Bacher, A, Fischer, M.
登録日2003-06-29
公開日2003-11-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structure of 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase from Methanococcus jannaschii in Complex with Divalent Metal Ions and the Substrate Ribulose 5-Phosphate: IMPLICATIONS FOR THE CATALYTIC MECHANISM
J.Biol.Chem., 278, 2003
1PVY
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3,4-dihydroxy-2-butanone 4-phosphate synthase from M. jannaschii in complex with ribulose 5-phosphate
分子名称: 3,4-dihydroxy-2-butanone 4-phosphate synthase, CALCIUM ION, RIBULOSE-5-PHOSPHATE, ...
著者Steinbacher, S, Schiffmann, S, Richter, G, Huber, R, Bacher, A, Fischer, M.
登録日2003-06-29
公開日2003-11-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase from Methanococcus jannaschii in Complex with Divalent Metal Ions and the Substrate Ribulose 5-Phosphate: IMPLICATIONS FOR THE CATALYTIC MECHANISM
J.Biol.Chem., 278, 2003
1ONP
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IspC complex with Mn2+ and fosmidomycin
分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, MANGANESE (II) ION
著者Steinbacher, S, Kaiser, J, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F.
登録日2003-02-28
公開日2003-03-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
J.BIOL.CHEM., 278, 2003
1TSP
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CRYSTAL STRUCTURE OF P22 TAILSPIKE PROTEIN: INTERDIGITATED SUBUNITS IN A THERMOSTABLE TRIMER
分子名称: TAILSPIKE-PROTEIN
著者Steinbacher, S, Seckler, R, Miller, S, Steipe, B, Huber, R, Reinemer, P.
登録日1994-06-16
公開日1995-09-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer.
Science, 265, 1994

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