4XZU
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![BU of 4xzu by Molmil](/molmil-images/mine/4xzu) | |
4MO3
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![BU of 4mo3 by Molmil](/molmil-images/mine/4mo3) | |
2EX5
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![BU of 2ex5 by Molmil](/molmil-images/mine/2ex5) | |
3QA9
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7S0P
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![BU of 7s0p by Molmil](/molmil-images/mine/7s0p) | Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine | 分子名称: | Coagulation factor VIII, PHOSPHOSERINE | 著者 | Peters, S.C, Childers, K.C, Wo, S.W, Brison, C.M, Swanson, C.D, Spiegel, P.C. | 登録日 | 2021-08-30 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII. Front Mol Biosci, 9, 2022
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8TY1
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8G6I
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![BU of 8g6i by Molmil](/molmil-images/mine/8g6i) | Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor VIII chimera from human and pig, NB33 heavy chain, ... | 著者 | Childers, K.C, Davulcu, O, Haynes, R.M, Lollar, P, Doering, C.B, Coxon, C.H, Spiegel, P.C. | 登録日 | 2023-02-15 | 公開日 | 2023-05-24 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (4.23 Å) | 主引用文献 | Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor. Blood, 142, 2023
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7K66
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![BU of 7k66 by Molmil](/molmil-images/mine/7k66) | Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2A9 heavy chain, ... | 著者 | Childers, K.C, Gish, J, Jarvis, L, Peters, S, Garrels, C, Smith, I.W, Spencer, H.T, Spiegel, P.C. | 登録日 | 2020-09-18 | 公開日 | 2020-10-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.92 Å) | 主引用文献 | Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor. Blood, 137, 2021
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7KBT
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![BU of 7kbt by Molmil](/molmil-images/mine/7kbt) | Factor VIII in complex with the anti-C2 domain antibody, G99 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Ronayne, E.K, Gish, J, Wilson, C, Peters, S, Spencer, H.T, Spiegel, P.C, Childers, K.C. | 登録日 | 2020-10-02 | 公開日 | 2020-11-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (4.15 Å) | 主引用文献 | Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor Front Immunol, 12, 2021
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6MF2
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![BU of 6mf2 by Molmil](/molmil-images/mine/6mf2) | Improved Model of Human Coagulation Factor VIII | 分子名称: | CALCIUM ION, COPPER (I) ION, Coagulation factor VIII, ... | 著者 | Smith, I.W, Spiegel, P.C. | 登録日 | 2018-09-08 | 公開日 | 2019-09-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.609364 Å) | 主引用文献 | The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain. J.Thromb.Haemost., 18, 2020
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6MF0
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![BU of 6mf0 by Molmil](/molmil-images/mine/6mf0) | Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (I) ION, ... | 著者 | Smith, I.W, Spiegel, P.C. | 登録日 | 2018-09-07 | 公開日 | 2019-09-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.19999886 Å) | 主引用文献 | The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain. J.Thromb.Haemost., 18, 2020
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4KI5
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![BU of 4ki5 by Molmil](/molmil-images/mine/4ki5) | Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99 | 分子名称: | Coagulation factor VIII, MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN, MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN, ... | 著者 | Walter, J.D, Meeks, S.L, Healey, J.F, Lollar, P, Spiegel, P.C. | 登録日 | 2013-05-01 | 公開日 | 2014-01-15 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes. Blood, 122, 2013
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