6MF0

Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII

Summary for 6MF0

• Entry DOI: 10.2210/pdb6mf0/pdb
• Related: 6MF2
• Descriptor: Coagulation factor VIII chimera, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: hemostasis, hemophilia a, factor viii, chimera, blood clotting
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 2
• Total formula weight: 342564.29

Authors

Smith, I.W.,Spiegel, P.C. (deposition date: 2018-09-07, release date: 2019-09-11, Last modification date: 2023-10-11)

• Primary citation: Smith, I.W.,d'Aquino, A.E.,Coyle, C.W.,Fedanov, A.,Parker, E.T.,Denning, G.,Spencer, H.T.,Lollar, P.,Doering, C.B.,Spiegel Jr., P.C.; The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.; J.Thromb.Haemost., 18:57-69, 2020; PubMed: 31454152; DOI: 10.1111/jth.14621

Experimental method

X-RAY DIFFRACTION (3.19999885698 Å)