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6MF0

Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII

Functional Information from GO Data
ChainGOidnamespacecontents
A0005507molecular_functioncopper ion binding
A0016491molecular_functionoxidoreductase activity
B0005507molecular_functioncopper ion binding
B0016491molecular_functionoxidoreductase activity
Functional Information from PROSITE/UniProt
site_idPS00079
Number of Residues21
DetailsMULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GqFlLfChISshHhGGMeahV
ChainResidueDetails
AGLY305-VAL325
AGLY686-LEU706
AGLY1994-PHE2014

site_idPS01285
Number of Residues28
DetailsFA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWstkepfs........WIkVDllapmiIhgIkTQG
ChainResidueDetails
AALA2061-GLY2088
AALA2218-GLY2247

site_idPS01286
Number of Residues17
DetailsFA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pthysirst..LRmELmGC
ChainResidueDetails
APRO2153-CYS2169
APRO2310-CYS2326

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Cleavage; by thrombin
ChainResidueDetails
AARG372
BARG372
AARG1624
BARG1624

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage (activation) => ECO:0000250
ChainResidueDetails
AARG1648
BARG1648

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by thrombin => ECO:0000250
ChainResidueDetails
AARG1689
BARG1689

site_idSWS_FT_FI4
Number of Residues28
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN214
AVAL2130
APHE2200
ALEU2273
AASN1810
BASN214
BASN240
BASP1794
BGLY1850
BTYR1890
BTYR1976
AASN240
BTRP2046
BVAL2073
BLYS2110
BVAL2130
BPHE2200
BLEU2273
BASN1810
AASN2118
BASN2118
AASP1794
AGLY1850
ATYR1890
ATYR1976
ATRP2046
AVAL2073
ALYS2110

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10368977
ChainResidueDetails
ATYR1602
ATYR1603
ATYR1607
BTYR1602
BTYR1603
BTYR1607

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN582
BASN582

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PDB entries from 2024-11-06

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