6MF0
Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Coagulation factor VIII chimera | polymer | 1467 | 168287.0 | 2 | UniProt (P12263) UniProt (P00451) Pfam (PF07732) Pfam (PF00394) Pfam (PF07731) Pfam (PF00754) | Sus scrofa (Pig) | Procoagulant component, Antihemophilic factor, AHF, Procoagulant component |
| 2 | C, E, F (C, E, F) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 3 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1260.2 | 1 | In PDB GlyTouCan (G35459KZ) | |||
| 5 | H (H) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 6 | I, L (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 7 | J, M (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 8 | K, N (A, B) | COPPER (I) ION | non-polymer | 63.5 | 2 | Chemie (CU1) | |||
| 9 | O, P (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: -18 - 367 (UniProt: P12263)
A, B: 368 - 1626 (UniProt: P00451)
A, B: 1627 - 1636 (UniProt: P12263)
A, B: 1637 - 2019 (UniProt: P12263)
A, B: 2020 - 2332 (UniProt: P00451)
A, B: 368 - 1626 (UniProt: P00451)
A, B: 1627 - 1636 (UniProt: P12263)
A, B: 1637 - 2019 (UniProt: P12263)
A, B: 2020 - 2332 (UniProt: P00451)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 336574.1 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 5652.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 338.1 | |
| All* | Total formula weight | 342564.3 |
