6MF2

Improved Model of Human Coagulation Factor VIII

Summary for 6MF2

• Entry DOI: 10.2210/pdb6mf2/pdb
• Related: 2R7E 6MF0
• Descriptor: Coagulation factor VIII, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: factor viii, hemophilia a, hemostasis, secreted, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 175837.85

Authors

Smith, I.W.,Spiegel, P.C. (deposition date: 2018-09-08, release date: 2019-09-11, Last modification date: 2020-07-29)

• Primary citation: Smith, I.W.,d'Aquino, A.E.,Coyle, C.W.,Fedanov, A.,Parker, E.T.,Denning, G.,Spencer, H.T.,Lollar, P.,Doering, C.B.,Spiegel Jr., P.C.; The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.; J.Thromb.Haemost., 18:57-69, 2020; PubMed: 31454152; DOI: 10.1111/jth.14621

Experimental method

X-RAY DIFFRACTION (3.6093641312 Å)