6MF2

Improved Model of Human Coagulation Factor VIII

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS01285
Number of Residues	28
Details	FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWstkepfs........WIkVDllapmiIhgIkTQG

Chain	Residue	Details
A	ALA2061-GLY2088
A	ALA2218-GLY2247

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site_id	PS01286
Number of Residues	17
Details	FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pthysirst..LRmELmGC

Chain	Residue	Details
A	PRO2153-CYS2169
A	PRO2310-CYS2326

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site_id	PS00079
Number of Residues	21
Details	MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GqFlLfChISshQhDGMeayV

Chain	Residue	Details
A	GLY304-VAL324
A	GLY686-LEU706
A	GLY1994-PHE2014

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Cleavage; by thrombin

Chain	Residue	Details
A	ARG372
A	ARG1561
A	ARG1689

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage (activation)

Chain	Residue	Details
A	GLY2134
A	ARG1648

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10368977, ECO:0000269|PubMed:1554716

Chain	Residue	Details
A	TYR346
A	TYR1664

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site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10368977

Chain	Residue	Details
A	TYR1539
A	TYR1540
A	TYR1544

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10368977, ECO:0000269|PubMed:1554716, ECO:0000269|PubMed:1898735

Chain	Residue	Details
A	TYR1680

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site_id	SWS_FT_FI6
Number of Residues	21
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN41
A	ASN239
A	GLU1578
A	GLU1605
A	GLU1649
A	ARG1721
A	ARG1764
A	SER1784
A	HIS1822
A	THR1826
A	PHE1876
A	LYS1887
A	LEU2006
A	LEU2076
A	ILE2080
A	ILE2103
A	GLY2121
A	ASP2233
A	SER2263
A	ASN1810
A	ASN2118

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN582

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