8G6I
Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor
Summary for 8G6I
Entry DOI | 10.2210/pdb8g6i/pdb |
EMDB information | 29770 |
Descriptor | Coagulation factor VIII chimera from human and pig, NB33 light chain, NB33 heavy chain, ... (4 entities in total) |
Functional Keywords | immune system, blood clotting |
Biological source | Sus scrofa (pig) More |
Total number of polymer chains | 3 |
Total formula weight | 215053.95 |
Authors | Childers, K.C.,Davulcu, O.,Haynes, R.M.,Lollar, P.,Doering, C.B.,Coxon, C.H.,Spiegel, P.C. (deposition date: 2023-02-15, release date: 2023-05-24, Last modification date: 2023-07-26) |
Primary citation | Childers, K.C.,Avery, N.G.,Estrada Alamo, K.A.,Davulcu, O.,Haynes, R.M.,Lollar, P.,Doering, C.B.,Coxon, C.H.,Spiegel, P.C. Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor. Blood, 142:197-201, 2023 Cited by PubMed: 37192299DOI: 10.1182/blood.2023020181 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.23 Å) |
Structure validation
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