8G6I

Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS00079
Number of Residues	21
Details	MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GqFlLfChISshHhGGMeahV

Chain	Residue	Details
A	GLY305-VAL325
A	GLY686-LEU706
A	GLY1994-PHE2014

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH

Chain	Residue	Details
C	TYR198-HIS204
B	TYR192-HIS198

---

site_id	PS01285
Number of Residues	28
Details	FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWstkepfs........WIkVDllapmiIhgIkTQG

Chain	Residue	Details
A	ALA2061-GLY2088
A	ALA2218-GLY2247

---

site_id	PS01286
Number of Residues	17
Details	FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pthysirst..LRmELmGC

Chain	Residue	Details
A	PRO2153-CYS2169
A	PRO2310-CYS2326

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Cleavage; by thrombin => ECO:0000250

Chain	Residue	Details
A	ARG372
A	ARG1689

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage (activation) => ECO:0000250

Chain	Residue	Details
A	ARG1648

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN214
A	ASN240
A	ASN1810
A	ASN2118

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by thrombin

Chain	Residue	Details
A	ARG1624

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10368977

Chain	Residue	Details
A	TYR1602
A	TYR1603
A	TYR1607

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN582

---