8G6I
Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor VIII chimera from human and pig | polymer | 1467 | 168287.0 | 1 | UniProt (P12263) UniProt (P00451) Pfam (PF07732) Pfam (PF00394) Pfam (PF07731) Pfam (PF00754) | Sus scrofa (pig) | Procoagulant component |
| 2 | B (B) | NB33 light chain | polymer | 211 | 22972.4 | 1 | Homo sapiens (human) | ||
| 3 | C (C) | NB33 heavy chain | polymer | 215 | 22945.7 | 1 | Homo sapiens (Human) | ||
| 4 | D, E (D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) |
Sequence modifications
A: -18 - 386 (UniProt: P12263)
A: 387 - 1626 (UniProt: P00451)
A: 1637 - 2019 (UniProt: P12263)
A: 2020 - 2332 (UniProt: P00451)
A: 387 - 1626 (UniProt: P00451)
A: 1637 - 2019 (UniProt: P12263)
A: 2020 - 2332 (UniProt: P00451)
| PDB | External Database | Details |
|---|---|---|
| Ala 1627 | - | linker |
| Gln 1628 | - | linker |
| Asn 1629 | - | linker |
| Ser 1630 | - | linker |
| Arg 1631 | - | linker |
| Pro 1632 | - | linker |
| Pro 1633 | - | linker |
| Ser 1634 | - | linker |
| Ala 1635 | - | linker |
| Ser 1636 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 214205.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| All* | Total formula weight | 215053.9 |
