2Y08
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![BU of 2y08 by Molmil](/molmil-images/mine/2y08) | Structure of the substrate-free FAD-dependent tirandamycin oxidase TamL | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Carlson, J.C, Li, S, Gunatilleke, S.S, Anzai, Y, Burr, D.A, Podust, L.M, Sherman, D.H. | Deposit date: | 2010-11-30 | Release date: | 2011-06-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes Nat.Chem, 3, 2011
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2Y4G
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![BU of 2y4g by Molmil](/molmil-images/mine/2y4g) | Structure of the Tirandamycin-bound FAD-dependent tirandamycin oxidase TamL in P212121 space group | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Carlson, J.C, Li, S, Gunatilleke, S.S, Anzai, Y, Burr, D.A, Podust, L.M, Sherman, D.H. | Deposit date: | 2011-01-05 | Release date: | 2011-06-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes Nat.Chem, 3, 2011
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3PT6
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![BU of 3pt6 by Molmil](/molmil-images/mine/3pt6) | Crystal structure of mouse DNMT1(650-1602) in complex with DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... | Authors: | Song, J, Patel, D.J. | Deposit date: | 2010-12-02 | Release date: | 2010-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
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7EKR
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![BU of 7ekr by Molmil](/molmil-images/mine/7ekr) | |
1FFT
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![BU of 1fft by Molmil](/molmil-images/mine/1fft) | The structure of ubiquinol oxidase from Escherichia coli | Descriptor: | COPPER (II) ION, HEME O, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Abramson, J, Riistama, S, Larsson, G, Jasaitis, A, Svensson-Ek, M, Puustinen, A, Iwata, S, Wikstrom, M. | Deposit date: | 2000-07-26 | Release date: | 2000-10-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site. Nat.Struct.Biol., 7, 2000
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5FWG
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![BU of 5fwg by Molmil](/molmil-images/mine/5fwg) | TETRA-(5-FLUOROTRYPTOPHANYL)-GLUTATHIONE TRANSFERASE | Descriptor: | (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE, TETRA-(5-FLUOROTRYPTOPHANYL)-GLUTATHIONE TRANSFERASE MU CLASS | Authors: | Parsons, J.F, Xiao, G, Armstrong, R.N, Gilliland, G.L. | Deposit date: | 1997-11-08 | Release date: | 1999-01-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Enzymes harboring unnatural amino acids: mechanistic and structural analysis of the enhanced catalytic activity of a glutathione transferase containing 5-fluorotryptophan. Biochemistry, 37, 1998
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3Q2A
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![BU of 3q2a by Molmil](/molmil-images/mine/3q2a) | Toluene 4 monooxygenase HD complex with inhibitor p-aminobenzoate | Descriptor: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-AMINOBENZOIC ACID, FE (III) ION, ... | Authors: | Acheson, J.F, Bailey, L.J, Fox, B.G. | Deposit date: | 2010-12-19 | Release date: | 2011-12-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase. Biochemistry, 51, 2012
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3Q3O
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![BU of 3q3o by Molmil](/molmil-images/mine/3q3o) | Toluene 4 monooxygenase HD complex with phenol | Descriptor: | FE (III) ION, PENTAETHYLENE GLYCOL, PHENOL, ... | Authors: | Acheson, J.F, Bailey, L.J, Fox, B.G. | Deposit date: | 2010-12-22 | Release date: | 2011-12-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase. Biochemistry, 51, 2012
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3MBZ
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![BU of 3mbz by Molmil](/molmil-images/mine/3mbz) | OXA-24 beta-lactamase complex soaked with 10mM SA4-17 inhibitor for 15min | Descriptor: | (2S,3R)-2-[(7-aminocarbonyl-2-methanoyl-indolizin-3-yl)amino]-4-aminocarbonyloxy-3-methyl-3-sulfino-butanoic acid, Betalactamase OXA24, SULFATE ION | Authors: | Sampson, J, van den Akker, F. | Deposit date: | 2010-03-26 | Release date: | 2011-03-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase J.Am.Chem.Soc., 132, 2010
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3Q14
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![BU of 3q14 by Molmil](/molmil-images/mine/3q14) | Toluene 4 monooxygenase HD Complex with p-cresol | Descriptor: | FE (III) ION, P-CRESOL, PENTAETHYLENE GLYCOL, ... | Authors: | Acheson, J.F, Bailey, L.J, Fox, B.G. | Deposit date: | 2010-12-16 | Release date: | 2011-12-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase. Biochemistry, 51, 2012
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3Q3M
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![BU of 3q3m by Molmil](/molmil-images/mine/3q3m) | Toluene 4 monooxygenase HD Complex with Inhibitor 4-Bromobenzoate | Descriptor: | 4-bromobenzoic acid, FE (III) ION, Toluene-4-monooxygenase system protein A, ... | Authors: | Acheson, J.F, Bailey, L.J, Fox, B.G. | Deposit date: | 2010-12-22 | Release date: | 2011-12-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.748 Å) | Cite: | Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase. Biochemistry, 51, 2012
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3Q3N
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![BU of 3q3n by Molmil](/molmil-images/mine/3q3n) | Toluene 4 monooxygenase HD complex with p-nitrophenol | Descriptor: | FE (III) ION, P-NITROPHENOL, PENTAETHYLENE GLYCOL, ... | Authors: | Acheson, J.F, Bailey, L.J, Fox, B.G. | Deposit date: | 2010-12-22 | Release date: | 2011-12-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase. Biochemistry, 51, 2012
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6B9L
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![BU of 6b9l by Molmil](/molmil-images/mine/6b9l) | Crystal structure of EphA2 with peptide 135E2 | Descriptor: | Ephrin type-A receptor 2, HIS TAG CLEAVED OFF, peptide 135E2, ... | Authors: | Song, J, Tan, X. | Deposit date: | 2017-10-10 | Release date: | 2018-10-17 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell. ACS Chem. Biol., 13, 2018
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8SH7
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![BU of 8sh7 by Molmil](/molmil-images/mine/8sh7) | |
7KSE
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![BU of 7kse by Molmil](/molmil-images/mine/7kse) | Crystal structure of Prototype Foamy Virus Protease-Reverse Transcriptase CSH mutant (selenomethionine-labeled) | Descriptor: | CALCIUM ION, Peptidase A9/Reverse transcriptase/RNase H | Authors: | Harrison, J.J.E.K, Das, K, Ruiz, F.X, Arnold, E. | Deposit date: | 2020-11-21 | Release date: | 2021-08-11 | Last modified: | 2021-09-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT). Viruses, 13, 2021
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7KSF
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![BU of 7ksf by Molmil](/molmil-images/mine/7ksf) | Crystal structure of Prototype Foamy Virus Protease-Reverse Transcriptase (native) | Descriptor: | CALCIUM ION, Protease/Reverse transcriptase/ribonuclease H | Authors: | Harrison, J.J.E.K, Das, K, Ruiz, F.X, Arnold, E. | Deposit date: | 2020-11-21 | Release date: | 2021-08-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT). Viruses, 13, 2021
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7KGY
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![BU of 7kgy by Molmil](/molmil-images/mine/7kgy) | Beta-glucuronidase from Faecalibacterium prausnitzii bound to the inhibitor UNC10201652-glucuronide | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, Beta-glucuronidase, GLYCEROL | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2020-10-19 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun, 13, 2022
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1R7I
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![BU of 1r7i by Molmil](/molmil-images/mine/1r7i) | HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution. | Descriptor: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, SULFATE ION | Authors: | Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. | Deposit date: | 2003-10-21 | Release date: | 2003-11-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase. To be Published
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1R31
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![BU of 1r31 by Molmil](/molmil-images/mine/1r31) | HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA | Descriptor: | (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ... | Authors: | Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. | Deposit date: | 2003-09-30 | Release date: | 2003-10-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase. To be Published
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5NWA
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![BU of 5nwa by Molmil](/molmil-images/mine/5nwa) | |
7LVT
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![BU of 7lvt by Molmil](/molmil-images/mine/7lvt) | Structure of full-length GluK1 with L-Glu | Descriptor: | Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1 | Authors: | Meyerson, J.R, Selvakumar, P. | Deposit date: | 2021-02-26 | Release date: | 2021-11-03 | Last modified: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural and compositional diversity in the kainate receptor family. Cell Rep, 37, 2021
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3PTA
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![BU of 3pta by Molmil](/molmil-images/mine/3pta) | Crystal structure of human DNMT1(646-1600) in complex with DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... | Authors: | Song, J, Patel, D.J. | Deposit date: | 2010-12-02 | Release date: | 2010-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
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6B9M
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3PT9
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![BU of 3pt9 by Molmil](/molmil-images/mine/3pt9) | Crystal structure of mouse DNMT1(731-1602) in the free state | Descriptor: | DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Song, J, Patel, D.J. | Deposit date: | 2010-12-02 | Release date: | 2010-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
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3OPP
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![BU of 3opp by Molmil](/molmil-images/mine/3opp) | ESBL R164S mutant of SHV-1 beta-lactamase complexed with SA2-13 | Descriptor: | (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | Sampson, J.M, van den Akker, F. | Deposit date: | 2010-09-01 | Release date: | 2011-07-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase. Antimicrob.Agents Chemother., 55, 2011
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