9B33
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9B35
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![BU of 9b35 by Molmil](/molmil-images/mine/9b35) | Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344 | 分子名称: | GLUTAMIC ACID, Glutamate receptor ionotropic, kainate 2 | 著者 | Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I. | 登録日 | 2024-03-18 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Kainate receptor channel opening and gating mechanism. Nature, 630, 2024
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9B38
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![BU of 9b38 by Molmil](/molmil-images/mine/9b38) | Kainate receptor GluK2 in complex with agonist glutamate with pseudo 4-fold symmetrical ligand-binding domain layer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I. | 登録日 | 2024-03-18 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Kainate receptor channel opening and gating mechanism. Nature, 630, 2024
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6PVO
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5WEL
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![BU of 5wel by Molmil](/molmil-images/mine/5wel) | GluA2 bound to antagonist ZK and GSG1L in digitonin, state 2 | 分子名称: | Chimera of Glutamate receptor 2, Germ cell-specific gene 1-like protein, Digitonin, ... | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2017-07-10 | 公開日 | 2017-08-02 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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7UGG
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![BU of 7ugg by Molmil](/molmil-images/mine/7ugg) | Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, SODIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2022-03-24 | 公開日 | 2022-06-08 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine. Nat Commun, 13, 2022
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3H5W
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![BU of 3h5w by Molmil](/molmil-images/mine/3h5w) | Crystal structure of the GluR2-ATD in space group P212121 without solvent | 分子名称: | Glutamate receptor 2 | 著者 | Jin, R, Singh, S.K, Gu, S, Furukawa, H, Sobolevsky, A, Zhou, J, Jin, Y, Gouaux, E. | 登録日 | 2009-04-22 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.686 Å) | 主引用文献 | Crystal structure and association behaviour of the GluR2 amino-terminal domain. Embo J., 28, 2009
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5WEN
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![BU of 5wen by Molmil](/molmil-images/mine/5wen) | GluA2 bound to GSG1L in digitonin, state 2 | 分子名称: | Digitonin, Glutamate receptor 2,Germ cell-specific gene 1-like protein | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2017-07-10 | 公開日 | 2017-08-02 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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6BO8
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![BU of 6bo8 by Molmil](/molmil-images/mine/6bo8) | Cryo-EM structure of human TRPV6 in nanodiscs | 分子名称: | Transient receptor potential cation channel subfamily V member 6 | 著者 | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | 登録日 | 2017-11-18 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Opening of the human epithelial calcium channel TRPV6. Nature, 553, 2018
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7K4E
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![BU of 7k4e by Molmil](/molmil-images/mine/7k4e) | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 30 | 分子名称: | 5-({4-[(1R,4S)-3'-methyl[1,2,3,4-tetrahydro[1,1'-biphenyl]]-4-yl]piperazin-1-yl}methyl)pyridin-2(1H)-one, Transient receptor potential cation channel subfamily V member 6 | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.34 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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6BOB
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![BU of 6bob by Molmil](/molmil-images/mine/6bob) | Cryo-EM structure of rat TRPV6* in nanodiscs | 分子名称: | Transient receptor potential cation channel subfamily V member 6 | 著者 | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | 登録日 | 2017-11-18 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Opening of the human epithelial calcium channel TRPV6. Nature, 553, 2018
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6BOA
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![BU of 6boa by Molmil](/molmil-images/mine/6boa) | Cryo-EM structure of human TRPV6-R470E in amphipols | 分子名称: | Transient receptor potential cation channel subfamily V member 6 | 著者 | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | 登録日 | 2017-11-18 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Opening of the human epithelial calcium channel TRPV6. Nature, 553, 2018
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6BO9
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![BU of 6bo9 by Molmil](/molmil-images/mine/6bo9) | Cryo-EM structure of human TRPV6 in amphipols | 分子名称: | Transient receptor potential cation channel subfamily V member 6 | 著者 | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | 登録日 | 2017-11-18 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Opening of the human epithelial calcium channel TRPV6. Nature, 553, 2018
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5KBS
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![BU of 5kbs by Molmil](/molmil-images/mine/5kbs) | Cryo-EM structure of GluA2-0xSTZ at 8.7 Angstrom resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2016-06-03 | 公開日 | 2016-07-13 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (8.7 Å) | 主引用文献 | Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science, 353, 2016
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7LR0
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![BU of 7lr0 by Molmil](/molmil-images/mine/7lr0) | Structure of squirrel TRPV1 in complex with capsaicin | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, Osm-9-like TRP channel 1, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-02-15 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12, 2021
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8SS3
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![BU of 8ss3 by Molmil](/molmil-images/mine/8ss3) | Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state) | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, Digitonin, ... | 著者 | Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. | 登録日 | 2023-05-08 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
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3H5V
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![BU of 3h5v by Molmil](/molmil-images/mine/3h5v) | Crystal structure of the GluR2-ATD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 | 著者 | Jin, R, Singh, S.K, Gu, S, Furukawa, H, Sobolevsky, A, Zhou, J, Jin, Y, Gouaux, E. | 登録日 | 2009-04-22 | 公開日 | 2009-06-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Crystal structure and association behaviour of the GluR2 amino-terminal domain. Embo J., 28, 2009
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7RAS
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7RAU
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7S89
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![BU of 7s89 by Molmil](/molmil-images/mine/7s89) | Open apo-state cryo-EM structure of human TRPV6 in cNW11 nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
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7S8C
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![BU of 7s8c by Molmil](/molmil-images/mine/7s8c) | Cryo-EM structure of human TRPV6 in complex with inhibitor econazole | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
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7S88
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![BU of 7s88 by Molmil](/molmil-images/mine/7s88) | Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
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7S8B
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![BU of 7s8b by Molmil](/molmil-images/mine/7s8b) | Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
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7K4F
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![BU of 7k4f by Molmil](/molmil-images/mine/7k4f) | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 31 | 分子名称: | 5-[(4-{cis-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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7K4D
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![BU of 7k4d by Molmil](/molmil-images/mine/7k4d) | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3OG | 分子名称: | 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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