5A27
| Leishmania major N-myristoyltransferase in complex with a chlorophenyl 1,2,4-oxadiazole inhibitor. | Descriptor: | 5-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | Authors: | Rackham, M.D, Yu, Z, Brannigan, J.A, Heal, W.P, Paape, D, Barker, K.V, Wilkinson, A.J, Smith, D.F, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2015-05-15 | Release date: | 2016-03-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Discovery of High Affinity Inhibitors of Leishmania Donovani N-Myristoyltransferase. Medchemcomm, 6, 2015
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1QJV
| Pectin methylesterase PemA from Erwinia chrysanthemi | Descriptor: | CHLORIDE ION, PECTIN METHYLESTERASE | Authors: | Jenkins, J, Mayans, O, Smith, D, Worboys, K, Pickersgill, R. | Deposit date: | 1999-07-05 | Release date: | 2000-07-14 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Three-Dimensional Structure of Erwinia Chrysanthemi Pectin Methylesterase Reveals a Novel Esterase Active Site J.Mol.Biol., 305, 2001
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1OOF
| Complex of Drosophila odorant binding protein LUSH with ethanol | Descriptor: | ACETATE ION, ETHANOL, odorant binding protein LUSH | Authors: | Kruse, S.W, Zhao, R, Smith, D.P, Jones, D.N.M. | Deposit date: | 2003-03-03 | Release date: | 2003-09-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster Nat.Struct.Biol., 10, 2003
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1OOI
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1OOG
| Complex of Drosophila odorant binding protein LUSH with propanol | Descriptor: | ACETATE ION, N-PROPANOL, odorant binding protein LUSH | Authors: | Kruse, S.W, Zhao, R, Smith, D.P, Jones, D.N.M. | Deposit date: | 2003-03-03 | Release date: | 2003-09-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster Nat.Struct.Biol., 10, 2003
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4N00
| Discovery of 7-THP chromans: BACE1 inhibitors that reduce A-beta in the CNS | Descriptor: | (4R,4a'S,10a'S)-2-amino-8'-(2-fluoropyridin-3-yl)-1-methyl-3',4',4a',10a'-tetrahydro-1'H-spiro[imidazole-4,10'-pyrano[4,3-b]chromen]-5(1H)-one, Beta-secretase 1, NICKEL (II) ION | Authors: | Vigers, G.P.A, Smith, D. | Deposit date: | 2013-09-30 | Release date: | 2014-05-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of 7-tetrahydropyran-2-yl chromans: beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid beta-protein (A beta ) in the central nervous system. J.Med.Chem., 57, 2014
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1Q44
| Crystal Structure of an Arabidopsis Thaliana Putative Steroid Sulfotransferase | Descriptor: | MALONIC ACID, Steroid Sulfotransferase | Authors: | Phillips Jr, G.N, Smith, D.W, Johnson, K.A, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2003-08-01 | Release date: | 2003-11-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of At2g03760, a putative steroid sulfotransferase from Arabidopsis thaliana Proteins, 57, 2004
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1OOH
| Complex of Drosophila odorant binding protein LUSH with butanol | Descriptor: | 1-BUTANOL, ACETATE ION, odorant binding protein LUSH | Authors: | Kruse, S.W, Zhao, R, Smith, D.P, Jones, D.N.M. | Deposit date: | 2003-03-03 | Release date: | 2003-09-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster Nat.Struct.Biol., 10, 2003
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1HIB
| THE STRUCTURE OF AN INTERLEUKIN-1 BETA MUTANT WITH REDUCED BIOACTIVITY SHOWS MULTIPLE SUBTLE CHANGES IN CONFORMATION THAT AFFECT PROTEIN-PROTEIN RECOGNITION | Descriptor: | INTERLEUKIN-1 BETA | Authors: | Camacho, N.P, Smith, D.R, Goldman, A, Schneider, B, Green, D, Young, P.R, Berman, H.M. | Deposit date: | 1993-03-29 | Release date: | 1994-01-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle changes in conformation that affect protein-protein recognition. Biochemistry, 32, 1993
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4L7J
| Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1) | Descriptor: | 2-[(3aS,7aR)-2-amino-3a-(2,4-difluorophenyl)-3a,6,7,7a-tetrahydro[1,3]oxazolo[4,5-c]pyridin-5(4H)-yl]pyridine-3-carbonitrile, ACETATE ION, Beta-secretase 1 | Authors: | Huestis, M.P, Liu, W, Volgraf, M, Purkey, H.E, Wang, W, Yu, C, Wu, P, Smith, D, Vigers, G, Dutcher, D, Geck Do, M.K, Hunt, K.W, Siu, M. | Deposit date: | 2013-06-13 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxycycloalkylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against β-Secretase-1 (BACE-1) Tetrahedron Lett., 2013
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4L7H
| Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1) | Descriptor: | 2-[(3aR,7aR)-2-amino-7a-(2,4-difluorophenyl)-3a,6,7,7a-tetrahydro[1,3]oxazolo[5,4-c]pyridin-5(4H)-yl]pyridine-3-carbonitrile, ACETATE ION, Beta-secretase 1, ... | Authors: | Huestis, M.P, Liu, W, Volgraf, M, Purkey, H.E, Wang, W, Yu, C, Wu, P, Smith, D, Vigers, G, Dutcher, D, Geck Do, M.K, Hunt, K.W, Siu, M. | Deposit date: | 2013-06-13 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxycycloalkylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against β-Secretase-1 (BACE-1) Tetrahedron Lett., 2013
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4L7G
| Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE1) | Descriptor: | (3aS,7aR)-7a-[3-(pyrimidin-5-yl)phenyl]-3a,6,7,7a-tetrahydro-4H-pyrano[4,3-d][1,3]oxazol-2-amine, Beta-secretase 1, DIMETHYL SULFOXIDE | Authors: | Huestis, M.P, Liu, W, Volgraf, M, Purkey, H, Wang, W, Yu, C, Wu, P, Smith, D, Vigers, G, Dutcher, D, Geck Do, M.K, Hunt, K.W, Siu, M. | Deposit date: | 2013-06-13 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxycycloalkylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against β-Secretase-1 (BACE-1) Tetrahedron Lett., 2013
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1Q45
| 12-0xo-phytodienoate reductase isoform 3 | Descriptor: | 12-oxophytodienoate-10,11-reductase, FLAVIN MONONUCLEOTIDE | Authors: | Phillips Jr, G.N, Johnson, K.A, Bingman, C.A, Smith, D.W, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2003-08-01 | Release date: | 2003-11-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray structure of Arabidopsis At2g06050, 12-oxophytodienoate reductase isoform 3 Proteins, 58, 2005
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1CO4
| SOLUTION STRUCTURE OF A ZINC DOMAIN CONSERVED IN YEAST COPPER-REGULATED TRANSCRIPTION FACTORS | Descriptor: | PROTEIN (ACTIVATOR OF METALLOTHIONEIN 1), ZINC ION | Authors: | Turner, R.B, Smith, D.L, Zawrotny, M.E, Summers, M.F, Posewitz, M.C, Winge, D.R. | Deposit date: | 1999-06-04 | Release date: | 1999-06-10 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors. Nat.Struct.Biol., 5, 1998
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1BHE
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1UC6
| Solution Structure of the Carboxyl Terminal Domain of the Ciliary Neurotrophic Factor Receptor | Descriptor: | Ciliary Neurotrophic Factor Receptor alpha | Authors: | Man, D, He, W, Sze, K.H, Ke, G, Smith, D.K, Ip, N.Y, Zhu, G. | Deposit date: | 2003-04-08 | Release date: | 2004-08-10 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex J.Biol.Chem., 278, 2003
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1HG7
| High resolution structure of HPLC-12 type III antifreeze protein from Ocean Pout Macrozoarces americanus | Descriptor: | HPLC-12 TYPE III ANTIFREEZE PROTEIN, SULFATE ION | Authors: | Antson, A.A, Smith, D.J, Roper, D.I, Lewis, S, Caves, L.S.D, Verma, C.S, Buckley, S.L, Lillford, P.J, Hubbard, R.E. | Deposit date: | 2000-12-13 | Release date: | 2001-01-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Understanding the Mechanism of Ice Binding by Type III Antifreeze Protein J.Mol.Biol., 305, 2001
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4LC7
| Aminooxazoline inhibitor of BACE-1 | Descriptor: | (3aR,7aR)-3a-[3-(5-chloropyridin-3-yl)phenyl]-3a,4,5,6,7,7a-hexahydro-1,3-benzoxazol-2-amine, Beta-Secretase-1, NICKEL (II) ION | Authors: | Huestis, M.P, Liu, W, Volgraf, M, Purkey, H.E, Wu, C, Wang, W, Smith, D, Vigers, G.P.A, Dutcher, D, Hunt, K.W, Siu, M. | Deposit date: | 2013-06-21 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxycycloalkylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against β-Secretase-1 (BACE-1) Tetrahedron Lett., 2013
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1Q4R
| Gene Product of At3g17210 from Arabidopsis Thaliana | Descriptor: | MAGNESIUM ION, protein At3g17210 | Authors: | Phillips Jr, G.N, Bingman, C.A, Johnson, K.A, Smith, D.W, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2003-08-04 | Release date: | 2003-11-25 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the protein from gene At3g17210 of Arabidopsis thaliana Proteins, 57, 2004
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1HFC
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1KT0
| Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes | Descriptor: | 51 KDA FK506-BINDING PROTEIN, SULFATE ION | Authors: | Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C. | Deposit date: | 2002-01-14 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a
component of steroid receptor complexes Proc.Natl.Acad.Sci.USA, 100, 2003
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1KT1
| Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes | Descriptor: | FK506-binding protein FKBP51, SULFATE ION | Authors: | Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C. | Deposit date: | 2002-01-14 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | STRUCTURE OF THE LARGE FK506-BINDING PROTEIN FKBP51, AN HSP90-BINDING PROTEIN AND A COMPONENT OF STEROID RECEPTOR COMPLEXES Proc.Natl.Acad.Sci.USA, 100, 2003
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1LDS
| Crystal Structure of monomeric human beta-2-microglobulin | Descriptor: | SODIUM ION, beta-2-microglobulin | Authors: | Trinh, C.H, Smith, D.P, Kalverda, A.P, Phillips, S.E.V, Radford, S.E. | Deposit date: | 2002-04-09 | Release date: | 2002-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties. Proc.Natl.Acad.Sci.USA, 99, 2002
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1BUY
| HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE | Descriptor: | PROTEIN (ERYTHROPOIETIN) | Authors: | Cheetham, J.C, Smith, D.M, Aoki, K.H, Stevenson, J.L, Hoeffel, T.J, Syed, R.S, Egrie, J, Harvey, T.S. | Deposit date: | 1998-09-08 | Release date: | 1999-09-10 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | NMR structure of human erythropoietin and a comparison with its receptor bound conformation. Nat.Struct.Biol., 5, 1998
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1UJL
| Solution Structure of the HERG K+ channel S5-P extracellular linker | Descriptor: | Potassium voltage-gated channel subfamily H member 2 | Authors: | Torres, A.M, Bansal, P.S, Sunde, M, Clarke, C.E, Bursill, J.A, Smith, D.J, Bauskin, A, Breit, S.N, Campbell, T.J, Alewood, P.F, Kuchel, P.W, Vandenberg, J.I. | Deposit date: | 2003-08-05 | Release date: | 2003-11-04 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix
in C-type inactivation. J.Biol.Chem., 278, 2003
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