2WSD
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![BU of 2wsd by Molmil](/molmil-images/mine/2wsd) | Proximal mutations at the type 1 Cu site of CotA-laccase: I494A mutant | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | Authors: | Silva, C.S, Durao, P, Chen, Z, Soares, C.M, Pereira, M.M, Todorovic, S, Hildebrandt, P, Martins, L.O, Lindley, P.F, Bento, I. | Deposit date: | 2009-09-04 | Release date: | 2010-09-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Proximal Mutations at the Type 1 Copper Site of Cota Laccase: Spectroscopic, Redox, Kinetic and Structural Characterization of I494A and L386A Mutants. Biochem.J., 412, 2008
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4A67
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![BU of 4a67 by Molmil](/molmil-images/mine/4a67) | Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant | Descriptor: | COPPER (II) ION, PEROXIDE ION, SPORE COAT PROTEIN A | Authors: | Silva, C.S, Lindley, P.F, Bento, I. | Deposit date: | 2011-10-31 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Role of Asp116 in the Reductive Cleavage of Dioxygen to Water in Cota Laccase: Assistance During the Proton Transfer Mechanism Acta Crystallogr.,Sect.D, 68, 2012
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4A68
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![BU of 4a68 by Molmil](/molmil-images/mine/4a68) | Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, COPPER (II) ION, ... | Authors: | Silva, C.S, Lindley, P.F, Bento, I. | Deposit date: | 2011-10-31 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Role of Asp116 in the Reductive Cleavage of Dioxygen to Water in Cota Laccase: Assistance During the Proton Transfer Mechanism Acta Crystallogr.,Sect.D, 68, 2012
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4A66
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![BU of 4a66 by Molmil](/molmil-images/mine/4a66) | Mutations in the neighbourhood of CotA-laccase trinuclear site: D116A mutant | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, PEROXIDE ION, ... | Authors: | Silva, C.S, Lindley, P.F, Bento, I. | Deposit date: | 2011-10-31 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Role of Asp116 in the Reductive Cleavage of Dioxygen to Water in Cota Laccase: Assistance During the Proton Transfer Mechanism Acta Crystallogr.,Sect.D, 68, 2012
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4AKO
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![BU of 4ako by Molmil](/molmil-images/mine/4ako) | Mutations in the neighbourhood of CotA-laccase trinuclear site: E498L mutant | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | Authors: | Silva, C.S, Chen, Z, Durao, P, Pereira, M.M, Todorovic, S, Hildebrandt, P, Martins, L.O, Lindley, P.F, Bento, I. | Deposit date: | 2012-02-28 | Release date: | 2012-03-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Role of Glu498 in the Dioxygen Reactivity of Cota-Laccase from Bacillus Subtilis. Dalton Trans, 39, 2010
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4AKP
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![BU of 4akp by Molmil](/molmil-images/mine/4akp) | Mutations in the neighbourhood of CotA-laccase trinuclear site: E498T mutant | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | Authors: | Silva, C.S, Chen, Z, Durao, P, Pereira, M.M, Todorovic, S, Hildebrandt, P, Martins, L.O, Lindley, P.F, Bento, I. | Deposit date: | 2012-02-28 | Release date: | 2012-03-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Role of Glu498 in the Dioxygen Reactivity of Cota-Laccase from Bacillus Subtilis. Dalton Trans, 39, 2010
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4AKQ
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![BU of 4akq by Molmil](/molmil-images/mine/4akq) | Mutations in the neighbourhood of CotA-laccase trinuclear site: E498D mutant | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | Authors: | Silva, C.S, Chen, Z, Durao, P, Pereira, M.M, Todorovic, S, Hildebrandt, P, Martins, L.O, Lindley, P.F, Bento, I. | Deposit date: | 2012-02-28 | Release date: | 2012-03-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Role of Glu498 in the Dioxygen Reactivity of Cota-Laccase from Bacillus Subtilis. Dalton Trans, 39, 2010
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3ZX1
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![BU of 3zx1 by Molmil](/molmil-images/mine/3zx1) | Multicopper oxidase from Campylobacter jejuni: a metallo-oxidase | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, OXIDOREDUCTASE, ... | Authors: | Silva, C.S, Durao, P, Fillat, A, Lindley, P.F, Martins, L.O, Bento, I. | Deposit date: | 2011-08-04 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of the Multicopper Oxidase from the Pathogenic Bacterium Campylobacter Jejuni Cgug11284: Characterization of a Metallo-Oxidase. Metallomics, 4, 2012
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1MZV
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![BU of 1mzv by Molmil](/molmil-images/mine/1mzv) | Crystal Structure of Adenine Phosphoribosyltransferase (APRT) From Leishmania tarentolae | Descriptor: | ADENOSINE MONOPHOSPHATE, Adenine Phosphoribosyltransferase, PHOSPHATE ION | Authors: | Thiemann, O.H, Silva, M, Oliva, G, Silva, C.H.T.P, Iulek, J. | Deposit date: | 2002-10-10 | Release date: | 2003-10-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of adenine phosphoribosyltransferase from Leishmania tarentolae: potential implications for APRT catalytic mechanism. Biochim.Biophys.Acta, 1696, 2004
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1ORE
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![BU of 1ore by Molmil](/molmil-images/mine/1ore) | Human Adenine Phosphoribosyltransferase | Descriptor: | ADENOSINE MONOPHOSPHATE, Adenine phosphoribosyltransferase, CHLORIDE ION | Authors: | Thiemann, O.H, Silva, M, Oliva, G, Silva, C.H.T.P, Iulek, J. | Deposit date: | 2003-03-12 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. Biochemistry, 43, 2004
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8G6P
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![BU of 8g6p by Molmil](/molmil-images/mine/8g6p) | Crystal structure of Mycobacterium thermoresistibile MurE in complex with ADP and 2,6-Diaminopimelic acid | Descriptor: | 2,6-DIAMINOPIMELIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Rossini, N.O, Silva, C.S, Dias, M.V.B. | Deposit date: | 2023-02-15 | Release date: | 2023-04-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The crystal structure of Mycobacterium thermoresistibile MurE ligase reveals the binding mode of the substrate m-diaminopimelate. J.Struct.Biol., 215, 2023
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1TO4
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![BU of 1to4 by Molmil](/molmil-images/mine/1to4) | Structure of the cytosolic Cu,Zn SOD from S. mansoni | Descriptor: | COPPER (II) ION, Superoxide dismutase, ZINC ION | Authors: | Cardoso, R.M.F, Silva, C.H.T.P, Ulian de Araujo, A.P, Tanaka, T, Tanaka, M, Garratt, R.C. | Deposit date: | 2004-06-12 | Release date: | 2004-08-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure of the cytosolic Cu,Zn superoxide dismutase from Schistosoma mansoni. Acta Crystallogr.,Sect.D, 60, 2004
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1TO5
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![BU of 1to5 by Molmil](/molmil-images/mine/1to5) | Structure of the cytosolic Cu,Zn SOD from S. mansoni | Descriptor: | ACETATE ION, COPPER (II) ION, Superoxide dismutase, ... | Authors: | Cardoso, R.M.F, Silva, C.H.T.P, Ulian de Araujo, A.P, Tanaka, T, Tanaka, M, Garratt, R.C. | Deposit date: | 2004-06-12 | Release date: | 2004-08-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the cytosolic Cu,Zn superoxide dismutase from Schistosoma mansoni. Acta Crystallogr.,Sect.D, 60, 2004
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5ME7
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![BU of 5me7 by Molmil](/molmil-images/mine/5me7) | Crystal Structure of eiF4E from C. melo | Descriptor: | Eukaryotic transcription initiation factor 4E, GLYCEROL | Authors: | Querol-Audi, J, Silva, C, Miras, M, Aranda-Regules, M, Verdaguer, N. | Deposit date: | 2016-11-14 | Release date: | 2017-08-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of eIF4E in Complex with an eIF4G Peptide Supports a Universal Bipartite Binding Mode for Protein Translation. Plant Physiol., 174, 2017
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5ME6
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![BU of 5me6 by Molmil](/molmil-images/mine/5me6) | Crystal Structure of eiF4E from C. melo bound to a CAP analog | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic transcription initiation factor 4E | Authors: | Querol-Audi, J, Silva, C, Miras, M, Aranda-Regules, M, Verdaguer, N. | Deposit date: | 2016-11-14 | Release date: | 2017-08-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of eIF4E in Complex with an eIF4G Peptide Supports a Universal Bipartite Binding Mode for Protein Translation. Plant Physiol., 174, 2017
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6GSD
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![BU of 6gsd by Molmil](/molmil-images/mine/6gsd) | Plantago Major multifunctional oxidoreductase in complex with progesterone and NADP+ | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROGESTERONE, Progesterone 5-beta-reductase | Authors: | Fellows, R, Silva, C, Russo, C.M, Lee, S.G, Jez, J.M, Chisholm, J.D, Zubieta, C, Nanao, M. | Deposit date: | 2018-06-14 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A multisubstrate reductase from Plantago major: structure-function in the short chain reductase superfamily. Sci Rep, 8, 2018
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5ME5
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![BU of 5me5 by Molmil](/molmil-images/mine/5me5) | Crystal Structure of eiF4E from C. melo bound to a eIF4G peptide | Descriptor: | Eukaryotic transcription initiation factor 4E, SULFATE ION, eIF4G | Authors: | Querol-Audi, J, Silva, C, Miras, M, Truniger, V, Aranda-Regules, M, Verdaguer, N. | Deposit date: | 2016-11-14 | Release date: | 2017-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of eIF4E in Complex with an eIF4G Peptide Supports a Universal Bipartite Binding Mode for Protein Translation. Plant Physiol., 174, 2017
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4ZPY
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![BU of 4zpy by Molmil](/molmil-images/mine/4zpy) | Structure of N170A MVM mutant empty capsid | Descriptor: | VP1 protein | Authors: | Guerra, P, Querol-Audi, J, Silva, C, Mateu, M.G, Verdaguer, N. | Deposit date: | 2015-05-08 | Release date: | 2017-05-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural basis for biologically relevant mechanical stiffening of a virus capsid by cavity-creating or spacefilling mutations. Sci Rep, 7, 2017
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2X87
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![BU of 2x87 by Molmil](/molmil-images/mine/2x87) | Crystal Structure of the reconstituted CotA | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, HYDROXIDE ION, ... | Authors: | Bento, I, Silva, C.S, Chen, Z, Martins, L.O, Lindley, P.F, Soares, C.M. | Deposit date: | 2010-03-06 | Release date: | 2010-09-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanisms Underlying Dioxygen Reduction in Laccases. Structural and Modelling Studies Focusing on Proton Transfer. Bmc Struct.Biol., 10, 2010
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2X88
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![BU of 2x88 by Molmil](/molmil-images/mine/2x88) | Crystal Structure of HoloCotA | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | Authors: | Bento, I, Silva, C.S, Chen, Z, Martins, L.O, Lindley, P.F, Soares, C.M. | Deposit date: | 2010-03-06 | Release date: | 2010-09-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanisms Underlying Dioxygen Reduction in Laccases. Structural and Modelling Studies Focusing on Proton Transfer. Bmc Struct.Biol., 10, 2010
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4AWE
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![BU of 4awe by Molmil](/molmil-images/mine/4awe) | The Crystal Structure of Chrysonilia sitophila endo-beta-D-1,4- mannanase | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goncalves, A.M.D, Silva, C.S, De Sanctis, D, Bento, I. | Deposit date: | 2012-06-01 | Release date: | 2012-10-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Endo-Beta-D-1,4-Mannanase from Chrysonilia Sitophila Displays a Novel Loop Arrangement for Substrate Selectivity Acta Crystallogr.,Sect.D, 68, 2012
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5A7I
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![BU of 5a7i by Molmil](/molmil-images/mine/5a7i) | Crystal structure of INPP5B in complex with biphenyl 3,3',4,4',5,5'- hexakisphosphate | Descriptor: | Biphenyl 3,3',4,4',5,5'-hexakisphosphate, CHLORIDE ION, GLYCEROL, ... | Authors: | Tresaugues, L, Mills, S.J, Silvander, C, Cozier, G, Potter, B.V.L, Norldund, P. | Deposit date: | 2015-07-06 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family. Biochemistry, 55, 2016
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8RXR
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![BU of 8rxr by Molmil](/molmil-images/mine/8rxr) | Crystal structure of VPS34 in complex with inhibitor SB02024 | Descriptor: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | Authors: | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | Deposit date: | 2024-02-07 | Release date: | 2024-03-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol, 2024
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5NHY
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![BU of 5nhy by Molmil](/molmil-images/mine/5nhy) | BAY-707 in complex with MTH1 | Descriptor: | 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, SULFATE ION, ... | Authors: | Ellermann, M, Eheim, A, Giese, A, Bunse, S, Nowak-Reppel, K, Neuhaus, R, Weiske, J, Quanz, M, Glasauer, A, Meyer, H, Queisser, N, Irlbacher, H, Bader, B, Rahm, F, Viklund, J, Andersson, M, Ericsson, U, Ginman, T, Forsblom, R, Lindstrom, J, Silvander, C, Tresaugues, L, Gorjanacz, M. | Deposit date: | 2017-03-22 | Release date: | 2017-07-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target. ACS Chem. Biol., 12, 2017
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5A7J
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![BU of 5a7j by Molmil](/molmil-images/mine/5a7j) | Crystal structure of INPP5B in complex with benzene 1,2,4,5- tetrakisphosphate | Descriptor: | (2,4,5-triphosphonooxyphenyl) dihydrogen phosphate, GLYCEROL, SULFATE ION, ... | Authors: | Tresaugues, L, Mills, S.J, Silvander, C, Cozier, G, Potter, B.V.L, Nordlund, P. | Deposit date: | 2015-07-06 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family. Biochemistry, 55, 2016
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