5A7I
Crystal structure of INPP5B in complex with biphenyl 3,3',4,4',5,5'- hexakisphosphate
Summary for 5A7I
Entry DOI | 10.2210/pdb5a7i/pdb |
Related | 5A7J |
Descriptor | TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE, GLYCEROL, Biphenyl 3,3',4,4',5,5'-hexakisphosphate, ... (7 entities in total) |
Functional Keywords | hydrolase, sgc, signalling, structural genomics consortium stockholm, magnesium binding, protein-inhbitor complex, inhibitor, phosphoinositides signalling |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytosol : P32019 |
Total number of polymer chains | 1 |
Total formula weight | 37367.94 |
Authors | Tresaugues, L.,Mills, S.J.,Silvander, C.,Cozier, G.,Potter, B.V.L.,Norldund, P. (deposition date: 2015-07-06, release date: 2016-04-13, Last modification date: 2024-01-10) |
Primary citation | Mills, S.J.,Silvander, C.,Cozier, G.,Tresaugues, L.,Nordlund, P.,Potter, B.V.L. Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family. Biochemistry, 55:1384-, 2016 Cited by PubMed: 26854536DOI: 10.1021/ACS.BIOCHEM.5B00838 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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