5VL3
| CD22 d1-d3 in complex with therapeutic Fab Epratuzumab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell receptor CD22, Epratuzumab Fab Heavy Chain, ... | Authors: | Sicard, T, Ereno-Orbea, J, Julien, J.P. | Deposit date: | 2017-04-24 | Release date: | 2017-10-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Molecular basis of human CD22 function and therapeutic targeting. Nat Commun, 8, 2017
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5VKK
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6ANA
| LL2 Fab in complex with anti-Kappa VHH domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, LL2 Fab Heavy Chain, LL2 Fab Light Chain, ... | Authors: | Sicard, T, Ereno Orbea, J, Julien, J.-P. | Deposit date: | 2017-08-12 | Release date: | 2018-01-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. J. Mol. Biol., 430, 2018
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6X4G
| Crystal structure of ICOS in complex with ICOS-L and an anti ICOS-L VNAR domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ICOS ligand, ... | Authors: | Rujas, E, Sicard, T, Julien, J.P. | Deposit date: | 2020-05-22 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11, 2020
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6X4T
| Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Rujas, E, Sicard, T, Julien, J.P. | Deposit date: | 2020-05-23 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11, 2020
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7JOO
| Crystal structure of ICOS in complex with antibody STIM003 and anti-kappa VHH domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Inducible T-cell costimulator, ... | Authors: | Rujas, E, Sicard, T, Julien, J.P. | Deposit date: | 2020-08-06 | Release date: | 2020-10-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11, 2020
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7O52
| CD22 d6-d7 in complex with Fab m971 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD22 d6-d7 Ig domains, GLYCEROL, ... | Authors: | Ereno-Orbea, J, Sicard, T, Julien, J.P. | Deposit date: | 2021-04-07 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22. J.Biol.Chem., 297, 2021
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7O4Y
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5VKJ
| Crystal structure of human CD22 Ig domains 1-3 | Descriptor: | B-cell receptor CD22, GLYCEROL, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Julien, J.P, Ereno-Orbea, J, Sicard, T. | Deposit date: | 2017-04-21 | Release date: | 2017-10-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Molecular basis of human CD22 function and therapeutic targeting. Nat Commun, 8, 2017
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5VKM
| Crystal structure of human CD22 Ig domains 1-3 in complex with alpha 2-6 sialyllactose | Descriptor: | B-cell receptor CD22, GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose, ... | Authors: | Julien, J.P, Ereno-Orbea, J, Sicard, T. | Deposit date: | 2017-04-21 | Release date: | 2017-10-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular basis of human CD22 function and therapeutic targeting. Nat Commun, 8, 2017
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6AND
| Pinatuzumab Fab in complex with anti-Kappa VHH domain | Descriptor: | Anti-kappa VHH domain, GLYCEROL, Pinatuzumab Fab Heavy chain, ... | Authors: | Ereno-Orbea, J, Sicard, T, Julien, J.-P. | Deposit date: | 2017-08-12 | Release date: | 2018-01-31 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. J. Mol. Biol., 430, 2018
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6ANI
| Coltuximab Fab in complex with anti-Kappa VHH domain | Descriptor: | Anti-Kappa VHH domain, Coltuximab Fab heavy chain, Coltuximab Fab light chain, ... | Authors: | Ereno Orbea, J, Sicard, T, Julien, J.-P. | Deposit date: | 2017-08-13 | Release date: | 2018-01-31 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. J. Mol. Biol., 430, 2018
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