5X70
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3WYW
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![BU of 3wyw by Molmil](/molmil-images/mine/3wyw) | Structural characterization of catalytic site of a Nilaparvata lugens delta-class glutathione transferase | Descriptor: | 1,2-ETHANEDIOL, GLUTATHIONE, Glutathione S-transferase | Authors: | Yamamoto, K, Higashiura, A, Nakagawa, A. | Deposit date: | 2014-09-09 | Release date: | 2015-01-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural characterization of the catalytic site of a Nilaparvata lugens delta-class glutathione transferase. Arch.Biochem.Biophys., 566C, 2014
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4A4Q
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![BU of 4a4q by Molmil](/molmil-images/mine/4a4q) | Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors | Descriptor: | PROTEASE, methyl [(2S)-1-{2-(2-{(3R,4S)-3-benzyl-4-hydroxy-1-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2-oxopyrrolidin-3-yl}ethyl)-2-[4-(pyridin-4-yl)benzyl]hydrazinyl}-3,3-dimethyl-1-oxobutan-2-yl]carbamate | Authors: | Wu, X, Ohrngren, P, Joshi, A.A, Trejos, A, Persson, M, Arvela, R.K, Wallberg, H, Vrang, L, Rosenquist, A, Samuelsson, B, Unge, J, Larhed, M. | Deposit date: | 2011-10-19 | Release date: | 2012-11-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Synthesis, X-Ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors. J.Med.Chem., 55, 2012
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4AN9
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![BU of 4an9 by Molmil](/molmil-images/mine/4an9) | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | Descriptor: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | Deposit date: | 2012-03-16 | Release date: | 2012-12-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973) Acs Med.Chem.Lett., 3, 2012
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2Q6H
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![BU of 2q6h by Molmil](/molmil-images/mine/2q6h) | Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and clomipramine | Descriptor: | 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ... | Authors: | Singh, S.K, Yamashita, A, Gouaux, E. | Deposit date: | 2007-06-05 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature, 448, 2007
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2QB4
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![BU of 2qb4 by Molmil](/molmil-images/mine/2qb4) | Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine | Descriptor: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ... | Authors: | Singh, S.K, Yamashita, A, Gouaux, E. | Deposit date: | 2007-06-15 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature, 448, 2007
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2QEI
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![BU of 2qei by Molmil](/molmil-images/mine/2qei) | Crystal structure analysis of LeuT complexed with L-alanine, sodium, and clomipramine | Descriptor: | 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, ALANINE, SODIUM ION, ... | Authors: | Singh, S.K, Yamashita, A, Gouaux, E. | Deposit date: | 2007-06-25 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature, 448, 2007
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2YY9
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![BU of 2yy9 by Molmil](/molmil-images/mine/2yy9) | Crystal structure of BTB domain from mouse HKR3 | Descriptor: | Zinc finger and BTB domain-containing protein 48 | Authors: | Kishishita, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-27 | Release date: | 2008-04-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of BTB domain from mouse HKR3 To be Published
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2Z0W
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![BU of 2z0w by Molmil](/molmil-images/mine/2z0w) | Crystal structure of the 2nd CAP-Gly domain in human Restin-like protein 2 reveals a swapped-dimer | Descriptor: | CAP-Gly domain-containing linker protein 4 | Authors: | Saito, K, Yoshikawa, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-07 | Release date: | 2007-11-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the 2nd CAP-Gly domain in human Restin-like protein 2 reveals a swapped-dimer To be Published
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2Z15
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![BU of 2z15 by Molmil](/molmil-images/mine/2z15) | Crystal structure of human Tob1 protein | Descriptor: | Protein Tob1 | Authors: | Saito, K, Kishishita, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-08 | Release date: | 2007-11-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of human Tob1 protein To be Published
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3VSS
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![BU of 3vss by Molmil](/molmil-images/mine/3vss) | Microbacterium saccharophilum K-1 beta-fructofuranosidase catalytic domain complexed with fructose | Descriptor: | Beta-fructofuranosidase, beta-D-fructofuranose | Authors: | Tonozuka, T, Tamaki, A, Yokoi, G, Miyazaki, T, Ichikawa, M, Nishikawa, A, Ohta, Y, Hidaka, Y, Katayama, K, Hatada, Y, Ito, T, Fujita, K. | Deposit date: | 2012-05-08 | Release date: | 2012-08-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Crystal structure of a lactosucrose-producing enzyme, Arthrobacter sp. K-1 beta-fructofuranosidase Enzyme.Microb.Technol., 51, 2012
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2Z0B
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![BU of 2z0b by Molmil](/molmil-images/mine/2z0b) | Crystal structure of CBM20 domain of human putative glycerophosphodiester phosphodiesterase 5 (KIAA1434) | Descriptor: | PHOSPHATE ION, Putative glycerophosphodiester phosphodiesterase 5 | Authors: | Saijo, S, Nishino, A, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-07 | Release date: | 2008-05-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of CBM20 domain of human putative glycerophosphodiester phosphodiesterase 5 (KIAA1434) To be Published
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3VVI
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5X71
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3VUQ
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![BU of 3vuq by Molmil](/molmil-images/mine/3vuq) | Crystal structure of TTHA0167, a transcriptional regulator, TetR/AcrR family from Thermus thermophilus HB8 | Descriptor: | Transcriptional regulator (TetR/AcrR family) | Authors: | Agari, Y, Sakamoto, K, Agari, K, Kuramitsu, S, Shinkai, A. | Deposit date: | 2012-07-04 | Release date: | 2013-02-27 | Last modified: | 2013-12-25 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure and function of a TetR family transcriptional regulator, SbtR, from thermus thermophilus HB8 Proteins, 81, 2013
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3VSR
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![BU of 3vsr by Molmil](/molmil-images/mine/3vsr) | Microbacterium saccharophilum K-1 beta-fructofuranosidase catalytic domain | Descriptor: | Beta-fructofuranosidase | Authors: | Tonozuka, T, Tamaki, A, Yokoi, G, Miyazaki, T, Ichikawa, M, Nishikawa, A, Ohta, Y, Hidaka, Y, Katayama, K, Hatada, Y, Ito, T, Fujita, K. | Deposit date: | 2012-05-08 | Release date: | 2012-08-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a lactosucrose-producing enzyme, Arthrobacter sp. K-1 beta-fructofuranosidase Enzyme.Microb.Technol., 51, 2012
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3VK9
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![BU of 3vk9 by Molmil](/molmil-images/mine/3vk9) | Crystal structure of delta-class glutathione transferase from silkmoth | Descriptor: | GLYCEROL, Glutathione S-transferase delta | Authors: | Kakuta, Y, Usuda, K, Higashiura, A, Suzuki, M, Nakagawa, A, Kimura, M, Yamamoto, K. | Deposit date: | 2011-11-10 | Release date: | 2012-10-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural basis for catalytic activity of a silkworm Delta-class glutathione transferase Biochim.Biophys.Acta, 1820, 2012
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3A58
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![BU of 3a58 by Molmil](/molmil-images/mine/3a58) | Crystal structure of Sec3p - Rho1p complex from Saccharomyces cerevisiae | Descriptor: | Exocyst complex component SEC3, GTP-binding protein RHO1, MAGNESIUM ION, ... | Authors: | Yamashita, M, Sato, Y, Yamagata, A, Mimura, H, Yoshikawa, A, Fukai, S. | Deposit date: | 2009-08-03 | Release date: | 2010-01-12 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for the Rho- and phosphoinositide-dependent localization of the exocyst subunit Sec3 Nat.Struct.Mol.Biol., 17, 2010
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5Y9T
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![BU of 5y9t by Molmil](/molmil-images/mine/5y9t) | Crystal Structure of EGFR T790M mutant in complex with naquotinib | Descriptor: | 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazin e-2-carboxamide, Epidermal growth factor receptor | Authors: | Mimasu, S, Tomimoto, Y, Maiko, I, Yasushi, A, Tatsuya, N. | Deposit date: | 2017-08-28 | Release date: | 2018-07-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, inEGFR-Mutated Non-Small Cell Lung Cancer. Mol. Cancer Ther., 17, 2018
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3W7W
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![BU of 3w7w by Molmil](/molmil-images/mine/3w7w) | Crystal structure of E. coli YgjK E727A complexed with 2-O-alpha-D-glucopyranosyl-alpha-D-galactopyranose | Descriptor: | CALCIUM ION, MAGNESIUM ION, Uncharacterized protein YgjK, ... | Authors: | Miyazaki, T, Ichikawa, M, Yokoi, G, Kitaoka, M, Mori, H, Kitano, Y, Nishikawa, A, Tonozuka, T. | Deposit date: | 2013-03-08 | Release date: | 2013-07-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a bacterial glycoside hydrolase family 63 enzyme in complex with its glycosynthase product, and insights into the substrate specificity. Febs J., 280, 2013
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3WOB
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![BU of 3wob by Molmil](/molmil-images/mine/3wob) | Crystal structure of a prostate-specific WGA16 glycoprotein lectin, form I | Descriptor: | hypothetical protein | Authors: | Garenaux, E, Kanagawa, M, Tsuchiyama, T, Hori, K, Kanazawa, T, Goshima, A, Chiba, M, Yasue, H, Ikeda, A, Yamaguchi, Y, Sato, C, Kitajima, K. | Deposit date: | 2013-12-26 | Release date: | 2014-12-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery, Primary, and Crystal Structures and Capacitation-related Properties of a Prostate-derived Heparin-binding Protein WGA16 from Boar Sperm J.Biol.Chem., 290, 2015
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3WTM
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![BU of 3wtm by Molmil](/molmil-images/mine/3wtm) | Crystal Structure of Lymnaea stagnalis Acetylcholine-Binding Protein Q55R Mutant Complexed with Nitromethylene Analogue of Imidacloprid | Descriptor: | 2-chloro-5-{[(2E)-2-(nitromethylidene)imidazolidin-1-yl]methyl}pyridine, Acetylcholine-binding protein | Authors: | Okajima, T, Ihara, M, Yamashita, A, Oda, T, Matsuda, K. | Deposit date: | 2014-04-11 | Release date: | 2015-02-04 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Studies on an acetylcholine binding protein identify a basic residue in loop G on the beta 1 strand as a new structural determinant of neonicotinoid actions Mol.Pharmacol., 86, 2014
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3WD6
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![BU of 3wd6 by Molmil](/molmil-images/mine/3wd6) | Crystal structure of Bombyx mori omega-class glutathione transferase in complex with GSH | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLUTATHIONE, ... | Authors: | Yamamoto, K, Suzuki, M, Higashiura, A, Nakagawa, A. | Deposit date: | 2013-06-07 | Release date: | 2014-07-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Three-dimensional structure of a Bombyx mori Omega-class glutathione transferase. Biochem.Biophys.Res.Commun., 438, 2013
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3WTL
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![BU of 3wtl by Molmil](/molmil-images/mine/3wtl) | Crystal Structure of Lymnaea stagnalis Acetylcholine Binding Protein Complexed with Nitromethylene Analogue of Imidacloprid | Descriptor: | 2-chloro-5-{[(2E)-2-(nitromethylidene)imidazolidin-1-yl]methyl}pyridine, Acetylcholine-binding protein | Authors: | Okajima, T, Ihara, M, Yamashita, A, Oda, T, Matsuda, K. | Deposit date: | 2014-04-11 | Release date: | 2015-02-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Studies on an acetylcholine binding protein identify a basic residue in loop G on the beta 1 strand as a new structural determinant of neonicotinoid actions Mol.Pharmacol., 86, 2014
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3A37
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![BU of 3a37 by Molmil](/molmil-images/mine/3a37) | Structural insight into the membrane insertion of tail-anchored proteins by Get3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATPase GET3, ZINC ION | Authors: | Yamagata, A, Mimura, H, Sato, Y, Yamashita, M, Yoshikawa, A, Fukai, S. | Deposit date: | 2009-06-10 | Release date: | 2010-01-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural insight into the membrane insertion of tail-anchored proteins by Get3 Genes Cells, 15, 2010
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