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PDB: 68 件
7BYM
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BU of 7bym by Molmil
Cryo-EM structure of human KCNQ4 with retigabine
分子名称: Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ...
著者Shen, H, Li, T, Yue, Z.
登録日2020-04-23
公開日2020-12-02
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
7BYL
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BU of 7byl by Molmil
Cryo-EM structure of human KCNQ4
分子名称: Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ...
著者Shen, H, Li, T, Yue, Z.
登録日2020-04-23
公開日2020-12-02
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
7BYN
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BU of 7byn by Molmil
Cryo-EM structure of human KCNQ4 with linopirdine
分子名称: 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one, Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, ...
著者Shen, H, Li, T, Yue, Z.
登録日2020-04-23
公開日2020-12-02
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
6W6C
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BU of 6w6c by Molmil
Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation
分子名称: Probable dimethyladenosine transferase
著者Shen, H, Stoute, J.
登録日2020-03-16
公開日2020-07-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structural and catalytic roles of the human 18SrRNA methyltransferases DIMT1 in ribosome assembly and translation.
J.Biol.Chem., 295, 2020
6W6F
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BU of 6w6f by Molmil
Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation
分子名称: Probable dimethyladenosine transferase
著者Shen, H, Stoute, J.
登録日2020-03-16
公開日2020-07-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural and catalytic roles of the human 18SrRNA methyltransferases DIMT1 in ribosome assembly and translation.
J.Biol.Chem., 295, 2020
8HLT
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BU of 8hlt by Molmil
The co-crystal structure of DYRK2 with YK-2-99B
分子名称: (6-{[(4P)-4-(1,3-benzothiazol-5-yl)-5-fluoropyrimidin-2-yl]amino}pyridin-3-yl)(piperazin-1-yl)methanone, Dual specificity tyrosine-phosphorylation-regulated kinase 2
著者Shen, H.T, Xiao, Y.B, Yuan, K, Yang, P, Li, Q.N.
登録日2022-12-01
公開日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.
J.Med.Chem., 66, 2023
6J8I
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BU of 6j8i by Molmil
Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (Y1755 up)
分子名称: (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Shen, H, Liu, D, Lei, J, Yan, N.
登録日2019-01-19
公開日2019-02-27
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.
Science, 363, 2019
6J8G
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BU of 6j8g by Molmil
Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (Y1755 up)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 9 subunit alpha, ...
著者Shen, H, Liu, D, Lei, J, Yan, N.
登録日2019-01-19
公開日2019-02-27
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.
Science, 363, 2019
6J8H
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BU of 6j8h by Molmil
Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (Y1755 down)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 9 subunit alpha, ...
著者Shen, H, Liu, D, Lei, J, Yan, N.
登録日2019-01-19
公開日2019-02-27
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.
Science, 363, 2019
6J8J
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BU of 6j8j by Molmil
Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (Y1755 down)
分子名称: (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Shen, H, Liu, D, Lei, J, Yan, N.
登録日2019-01-19
公開日2019-02-27
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.
Science, 363, 2019
5VXO
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BU of 5vxo by Molmil
Crystal Structure Analysis of human CLYBL in complex with propionyl-CoA
分子名称: 1,2-ETHANEDIOL, Citrate lyase subunit beta-like protein, mitochondrial, ...
著者Shen, H.
登録日2017-05-23
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.266 Å)
主引用文献The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.
Cell, 171, 2017
5VXS
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BU of 5vxs by Molmil
Crystal Structure Analysis of human CLYBL in apo form
分子名称: CITRIC ACID, Citrate lyase subunit beta-like protein, mitochondrial
著者Shen, H.
登録日2017-05-24
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.954 Å)
主引用文献The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.
Cell, 171, 2017
5X0M
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BU of 5x0m by Molmil
Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, ...
著者Shen, H, Zhou, Q, Pan, X, Li, Z, Wu, J, Yan, N.
登録日2017-01-21
公開日2017-03-08
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.
Science, 355, 2017
6A90
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BU of 6a90 by Molmil
Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and Dc1a
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mu-diguetoxin-Dc1a, ...
著者Shen, H.Z, li, Z.Q, Jiang, Y, Pan, X.J, Wu, J.P, Cristofori-Armstrong, B, Smith, J.J, Chin, Y.K.Y, Lei, J.L, Zhou, Q, King, G.F, Yan, N.
登録日2018-07-11
公開日2018-08-08
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Science, 362, 2018
6A91
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BU of 6a91 by Molmil
Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Shen, H.Z, li, Z.Q, Jiang, Y, Pan, X.J, Wu, J.P, Cristofori-Armstrong, B, Smith, J.J, Chin, Y.K.Y, Lei, J.L, Zhou, Q, King, G.F, Yan, N.
登録日2018-07-11
公開日2018-08-08
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Science, 362, 2018
6A95
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BU of 6a95 by Molmil
Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with tetrodotoxin and Dc1a
分子名称: (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Shen, H.Z, li, Z.Q, Jiang, Y, Pan, X.J, Wu, J.P, Cristofori-Armstrong, B, Smith, J.J, Chin, Y.K.Y, Lei, J.L, Zhou, Q, King, G.F, Yan, N.
登録日2018-07-11
公開日2018-08-08
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Science, 362, 2018
5VXC
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BU of 5vxc by Molmil
Crystal Structure Analysis of human CLYBL in complex with free CoASH
分子名称: COENZYME A, Citrate lyase subunit beta-like protein, mitochondrial, ...
著者Shen, H.
登録日2017-05-23
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.872 Å)
主引用文献The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.
Cell, 171, 2017
7YG2
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BU of 7yg2 by Molmil
Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DBLMSP2, ...
著者Shen, H, Ji, C, Xiao, J.
登録日2022-07-09
公開日2023-03-29
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M.
Nat Commun, 14, 2023
7Y09
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BU of 7y09 by Molmil
Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ...
著者Shen, H, Ji, C, Xiao, J.
登録日2022-06-03
公開日2023-03-29
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M.
Nat Commun, 14, 2023
8K66
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BU of 8k66 by Molmil
Cryo-EM structure of Oryza sativa HKT2;1 at 2.5 angstrom
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ...
著者Wang, X, Shen, X, Qu, Y, Wang, C, Shen, H.
登録日2023-07-25
公開日2024-04-03
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.53 Å)
主引用文献Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.
Nat.Plants, 10, 2024
8K69
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Cryo-EM structure of Oryza sativa HKT2;2/1 at 2.3 angstrom
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ...
著者Wang, X, Shen, X, Qu, Y, Wang, C, Shen, H.
登録日2023-07-25
公開日2024-04-03
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.33 Å)
主引用文献Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.
Nat.Plants, 10, 2024
5J8J
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BU of 5j8j by Molmil
A histone deacetylase from Saccharomyces cerevisiae
分子名称: Histone deacetylase HDA1
著者Zhu, Y, Shen, H, Li, X, Teng, M.
登録日2016-04-07
公開日2017-04-19
実験手法X-RAY DIFFRACTION (2.716 Å)
主引用文献Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae.
Sci Rep, 6, 2016
8WY3
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BU of 8wy3 by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 21
分子名称: Bromodomain-containing protein 4, ~{N}-cyclopropyl-2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]ethanamide
著者Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X.
登録日2023-10-30
公開日2024-01-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
J.Med.Chem., 67, 2024
8WXY
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BU of 8wxy by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 23
分子名称: 5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-4-[(2-morpholin-4-yl-2-oxidanylidene-ethyl)amino]pyridin-2-one, Bromodomain-containing protein 4, GLYCEROL
著者Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X.
登録日2023-10-30
公開日2024-01-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
J.Med.Chem., 67, 2024
8WY7
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BU of 8wy7 by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 22
分子名称: 2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]-~{N}-(4-oxidanylcyclohexyl)ethanamide, Bromodomain-containing protein 4
著者Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X.
登録日2023-10-30
公開日2024-01-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
J.Med.Chem., 67, 2024

 

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