5LXF
| Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant | 分子名称: | Macrophage colony-stimulating factor 1 | 著者 | Shahar, A, Papo, N, Zarivach, R, Kosloff, M, Bakhman, A, Rosenfeld, L, Zur, Y, Levaot, N. | 登録日 | 2016-09-21 | 公開日 | 2017-07-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor. Biochem. J., 474, 2017
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5NX1
| Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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5NX3
| Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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3RTK
| Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A | 分子名称: | 60 kDa chaperonin 2, MAGNESIUM ION | 著者 | Shahar, A, Melamed-Frank, M, Kashi, Y, Adir, N. | 登録日 | 2011-05-03 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The dimeric structure of the Cpn60.2 chaperonin of Mycobacterium tuberculosis at 2.8 A reveals possible modes of function. J.Mol.Biol., 412, 2011
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6XXO
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6XXP
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6XXN
| Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen | 分子名称: | NB_7_a,b,c,f, NB_7_g, NB_7_h, ... | 著者 | Shahar, A, Rosenfeld, L, Papo, N. | 登録日 | 2020-01-28 | 公開日 | 2020-06-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Nanobodies Targeting Prostate-Specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer. J.Med.Chem., 63, 2020
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7R3B
| S-adenosylmethionine synthetase from Lactobacillus plantarum complexed with AMPPNP, methionine and SAM | 分子名称: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, PHENYLALANINE, ... | 著者 | Shahar, A, Kleiner, D, Bershtein, S, Zarivach, R. | 登録日 | 2022-02-07 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Evolution of homo-oligomerization of methionine S-adenosyltransferases is replete with structure-function constrains. Protein Sci., 31, 2022
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7R2W
| Mutant S-adenosylmethionine synthetase from E.coli complexed with AMPPNP and methionine | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, POTASSIUM ION, ... | 著者 | Shahar, A, Kleiner, D, Bershtein, S, Zarivach, R. | 登録日 | 2022-02-06 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Evolution of homo-oligomerization of methionine S-adenosyltransferases is replete with structure-function constrains. Protein Sci., 31, 2022
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6GFI
| Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S. | 登録日 | 2018-04-30 | 公開日 | 2018-09-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries. Nat Commun, 9, 2018
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6HAR
| Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ... | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N. | 登録日 | 2018-08-08 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.497 Å) | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J.Biol.Chem., 294, 2019
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3W93
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3W8V
| Crystal Structure Analysis of the synthetic GCN4 coiled coil peptide | 分子名称: | 1,2-ETHANEDIOL, GCN4n coiled coil peptide, PARA ACETAMIDO BENZOIC ACID | 著者 | Shahar, A, Zarivach, R, Ashkenasy, G. | 登録日 | 2013-03-21 | 公開日 | 2014-02-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A high-resolution structure that provides insight into coiled-coil thiodepsipeptide dynamic chemistry Angew.Chem.Int.Ed.Engl., 52, 2013
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3W92
| Crystal Structure Analysis of the synthetic GCN4 Thioester coiled coil peptide | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, PARA ACETAMIDO BENZOIC ACID, ... | 著者 | Shahar, A, Zarivach, R, Ashkenasy, G. | 登録日 | 2013-03-24 | 公開日 | 2014-02-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | A high-resolution structure that provides insight into coiled-coil thiodepsipeptide dynamic chemistry Angew.Chem.Int.Ed.Engl., 52, 2013
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6RNG
| Dipeptide Gly-Pro binds to a glycolytic enzyme fructose bisphosphate aldolase | 分子名称: | Fructose-bisphosphate aldolase 6, cytosolic, GLYCINE, ... | 著者 | Shahar, A, Zarivach, R, Skirycz, A, Wojciechowska, I. | 登録日 | 2019-05-08 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Dipeptide Gly-Pro binds to a glycolytic enzyme fructose bisphosphate aldolase Not Published
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6RS1
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6RJS
| Inter-dimeric interface controls function and stability of S-methionine adenosyltransferase from U. urealiticum | 分子名称: | Methionine adenosyltransferase | 著者 | Shahar, A, Zarivach, R, Bershtein, S, Kleiner, D, Shmulevich, F. | 登録日 | 2019-04-29 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase. J.Mol.Biol., 431, 2019
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6RK7
| Inter-dimeric interface controls function and stability of S-methionine adenosyltransferase from U. urealiticum | 分子名称: | CHLORIDE ION, Methionine adenosyltransferase, S-ADENOSYLMETHIONINE | 著者 | Shahar, A, Zarivach, R, Bershtein, S, Kleiner, D, Shmulevich, F. | 登録日 | 2019-04-30 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase. J.Mol.Biol., 431, 2019
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6RKC
| Inter-dimeric interface controls function and stability of S-methionine adenosyltransferase from U. urealiticum | 分子名称: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, Methionine adenosyltransferase, ... | 著者 | Shahar, A, Zarivach, R, Bershtein, S, Kleiner, D, Shmulevich, F. | 登録日 | 2019-04-30 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase. J.Mol.Biol., 431, 2019
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6RKA
| Inter-dimeric interface controls function and stability of S-methionine adenosyltransferase from U. urealiticum | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Methionine adenosyltransferase, PHOSPHATE ION, ... | 著者 | Shahar, A, Zarivach, R, Bershtein, S, Kleiner, D, Shmulevich, F. | 登録日 | 2019-04-30 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase. J.Mol.Biol., 431, 2019
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6RK5
| Inter-dimeric interface controls function and stability of S-methionine adenosyltransferase from U. urealiticum | 分子名称: | Methionine adenosyltransferase | 著者 | Shahar, A, Zarivach, R, Bershtein, S, Kleiner, D, Shmulevich, F. | 登録日 | 2019-04-30 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase. J.Mol.Biol., 431, 2019
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8QU9
| Structure of the NCOA4 (Nuclear Receptor Coactivator 4)-FTH1 (H-Ferritin) complex | 分子名称: | FE (III) ION, Ferritin heavy chain, NCOA4 (Nuclear Receptor Coactivator 4) | 著者 | Hoelzgen, F, Klukin, E, Zalk, R, Shahar, A, Cohen-Schwartz, S, Frank, G.A. | 登録日 | 2023-10-15 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural basis for the intracellular regulation of ferritin degradation. Nat Commun, 15, 2024
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7O85
| Anthrax toxin prepore in complex with the neutralizing Fab cAb29 | 分子名称: | CALCIUM ION, Fab, Protective antigen PA-63 | 著者 | Hoelzgen, F, Zalk, R, Alcalay, R, Cohen-Schwartz, S, Garau, G, Shahar, A, Mazor, O, Frank, G.A. | 登録日 | 2021-04-14 | 公開日 | 2021-04-28 | 最終更新日 | 2021-09-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Neutralization of the anthrax toxin by antibody-mediated stapling of its membrane-penetrating loop. Acta Crystallogr D Struct Biol, 77, 2021
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4X71
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 methanol stable variant A269T | 分子名称: | CALCIUM ION, Lipase, ZINC ION | 著者 | Kanteev, M, Dror, A, Gihaz, S, Shahar, A, Fishman, A. | 登録日 | 2014-12-09 | 公開日 | 2015-06-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural insights into methanol-stable variants of lipase T6 from Geobacillus stearothermophilus. Appl.Microbiol.Biotechnol., 99, 2015
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9ETU
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