5LXF

Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant

Summary for 5LXF

• Entry DOI: 10.2210/pdb5lxf/pdb
• Descriptor: Macrophage colony-stimulating factor 1 (2 entities in total)
• Functional Keywords: drug design, rational protein engineering, receptor tyrosine kinase, osteoporosis, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 42709.47

Authors

Shahar, A.,Papo, N.,Zarivach, R.,Kosloff, M.,Bakhman, A.,Rosenfeld, L.,Zur, Y.,Levaot, N. (deposition date: 2016-09-21, release date: 2017-07-12, Last modification date: 2024-01-17)

• Primary citation: Zur, Y.,Rosenfeld, L.,Bakhman, A.,Ilic, S.,Hayun, H.,Shahar, A.,Akabayov, B.,Kosloff, M.,Levaot, N.,Papo, N.; Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.; Biochem. J., 474:2601-2617, 2017; PubMed: 28655719; DOI: 10.1042/BCJ20170276

Experimental method

X-RAY DIFFRACTION (2 Å)