5LXF

Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Macrophage colony-stimulating factor 1	polymer	182	21354.7	2	UniProt (P09603) Pfam (PF05337)	Homo sapiens (Human)	MCSF,Lanimostim
2	C, D (A, B)	water	water		18.0	261	Chemie (HOH)

Sequence modifications

A, B: 1 - 158 (UniProt: P09603)

PDB	External Database	Details
Tyr -11	-	expression tag
Val -10	-	expression tag
Asp -9	-	expression tag
Tyr -8	-	expression tag
Lys -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Lys -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag
Ser 31	Cys 63	engineered mutation
Pro 159	-	expression tag
Arg 160	-	expression tag
His 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
Ala 167	-	expression tag
Ala 168	-	expression tag
Ala 169	-	expression tag
Asn 170	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42709.5
All*	Total formula weight	42709.5

*Water molecules are not included.