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PDB: 299 件
7TTC
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BamABCDE bound to substrate EspP
分子名称: 2,3-dideoxy-6-O-[2-deoxy-4-O-phosphono-2-(tetradecanoylamino)-alpha-L-gulopyranosyl]-1-O-phosphono-beta-D-threo-hexopyranose, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ...
著者Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D.
登録日2022-02-01
公開日2022-03-30
最終更新日2022-04-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding.
Cell, 185, 2022
7TT5
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BamABCDE bound to substrate EspP in the open-sheet EspP state
分子名称: Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, ...
著者Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D.
登録日2022-01-31
公開日2022-03-30
最終更新日2022-04-13
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding.
Cell, 185, 2022
7TT2
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BamABCDE bound to substrate EspP class 3
分子名称: Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ...
著者Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D.
登録日2022-01-31
公開日2022-03-30
最終更新日2022-04-13
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding.
Cell, 185, 2022
2XZ1
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BU of 2xz1 by Molmil
The Structure of the 2:2 (Fully Occupied) Complex Between Stearoyl Acyl Carrier Protein Desaturase from Ricinus Communis (Castor Bean) and Acyl Carrier Protein.
分子名称: (2R)-2,4-dihydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide, ACYL CARRIER PROTEIN 1, CHLOROPLASTIC, ...
著者Guy, J.E, Moche, M, Whittle, E, Lengqvist, J, Shanklin, J, Lindqvist, Y.
登録日2010-11-22
公開日2011-09-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Remote Control of Regioselectivity in Acyl-Acyl Carrier Protein-Desaturases.
Proc.Natl.Acad.Sci.USA, 108, 2011
3ZYS
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BU of 3zys by Molmil
Human dynamin 1 deltaPRD polymer stabilized with GMPPCP
分子名称: DYNAMIN-1, INTERFERON-INDUCED GTP-BINDING PROTEIN MX1
著者Chappie, J.S, Mears, J.A, Fang, S, Leonard, M, Schmid, S.L, Milligan, R.A, Hinshaw, J.E, Dyda, F.
登録日2011-08-24
公開日2011-10-12
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (12.2 Å)
主引用文献A Pseudoatomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke.
Cell(Cambridge,Mass.), 147, 2011
3ZBX
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BU of 3zbx by Molmil
X-ray Structure of c-Met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline.
分子名称: 6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline, HEPATOCYTE GROWTH FACTOR RECEPTOR
著者McTigue, M, Wickersham, J, Ryan, K.
登録日2012-11-13
公開日2013-11-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Lessons from (S)-6-(1-(6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2, 4]Triazolo[4,3-B]Pyridazin-3-Yl)Ethyl)Quinoline (Pf-04254644), an Inhibitor of Receptor Tyrosine Kinase C-met with High Protein Kinase Selectivity But Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats.
J.Med.Chem., 56, 2013
5W0B
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Structure of human TUT7 catalytic module (CM)
分子名称: IODIDE ION, SULFATE ION, Terminal uridylyltransferase 7, ...
著者Faehnle, C.R, Walleshauser, J, Joshua-Tor, L.
登録日2017-05-30
公開日2017-06-28
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.614 Å)
主引用文献Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Nat. Struct. Mol. Biol., 24, 2017
1Z71
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thrombin and P2 pyridine N-oxide inhibitor complex structure
分子名称: Hirudin IIIB', L17, thrombin
著者Nantermet, P.G, Burgey, C.S, Robinson, K.A, Pellicore, J.M, Newton, C.L, Deng, J.Z, Lyle, T.A, Selnick, H.G, Lewis, S.D, Lucas, B.J, Krueger, J.A, Miller-Stein, C, White, R.B, Wong, B, McMasters, D.R, Wallace, A.A, Lynch Jr, J.J, Yan, Y, Chen, Z, Kuo, L, Gardell, S.J, Shafer, J.A, Vacca, J.P.
登録日2005-03-23
公開日2005-05-17
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献P(2) pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold
BIOORG.MED.CHEM.LETT., 15, 2005
5W0O
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Structure of human TUT7 catalytic module (CM) in complex with dsRNA
分子名称: Terminal uridylyltransferase 7, URIDINE 5'-TRIPHOSPHATE, double-stranded RNA
著者Faehnle, C.R, Walleshauser, J, Joshua-Tor, L.
登録日2017-05-31
公開日2017-06-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.488 Å)
主引用文献Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Nat. Struct. Mol. Biol., 24, 2017
5WP9
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BU of 5wp9 by Molmil
Structural Basis of Mitochondrial Receptor Binding and Constriction by Dynamin-Related Protein 1
分子名称: Dynamin-1-like protein, MAGNESIUM ION, Mitochondrial dynamics protein MID49, ...
著者Kalia, R, Wang, R.Y.R, Yusuf, A, Thomas, P.V, Agard, D.A, Shaw, J.M, Frost, A.
登録日2017-08-03
公開日2018-06-20
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.22 Å)
主引用文献Structural basis of mitochondrial receptor binding and constriction by DRP1.
Nature, 558, 2018
4ZZM
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BU of 4zzm by Molmil
Human ERK2 in complex with an irreversible inhibitor
分子名称: 7-ethylsulfonyl-N-(oxan-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-amine, MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION
著者Ward, R.A, Colclough, N, Challinor, M, Debreczeni, J.E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, James, M, Jones, C.D, Jones, C.R, Renshaw, J, Roberts, K, Snow, L, Tonge, M, Yeung, K.
登録日2015-04-10
公開日2015-05-27
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2.
J.Med.Chem., 58, 2015
4ZZO
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Human ERK2 in complex with an irreversible inhibitor
分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 1, N-[2-[[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]amino]phenyl]propanamide, SULFATE ION
著者Ward, R.A, Colclough, N, Challinor, M, Debreczeni, J.E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, James, M, Jones, C.D, Jones, C.R, Renshaw, J, Roberts, K, Snow, L, Tonge, M, Yeung, K.
登録日2015-04-10
公開日2015-05-27
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2.
J.Med.Chem., 58, 2015
8EFS
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BU of 8efs by Molmil
CryoEM of the soluble OPA1 tetramer from the apo helical assembly on a lipid membrane
分子名称: Dynamin-like 120 kDa protein, form S1
著者Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E.
登録日2022-09-09
公開日2023-06-28
最終更新日2023-09-13
実験手法ELECTRON MICROSCOPY (9.68 Å)
主引用文献OPA1 helical structures give perspective to mitochondrial dysfunction.
Nature, 620, 2023
3ZYC
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BU of 3zyc by Molmil
DYNAMIN 1 GTPASE GED FUSION DIMER COMPLEXED WITH GMPPCP
分子名称: DYNAMIN-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
著者Chappie, J.S, Mears, J.A, Fang, S, Leonard, M, Schmid, S.L, Milligan, R.A, Hinshaw, J.E, Dyda, F.
登録日2011-08-22
公開日2011-10-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A Pseudoatomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke.
Cell(Cambridge,Mass.), 147, 2011
4ZZN
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Human ERK2 in complex with an inhibitor
分子名称: 2-[[5-chloranyl-2-(oxan-4-ylamino)pyridin-4-yl]amino]-N-methyl-benzamide, MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION
著者Ward, R.A, Colclough, N, Challinor, M, Debreczeni, J.E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, James, M, Jones, C.D, Jones, C.R, Renshaw, J, Roberts, K, Snow, L, Tonge, M, Yeung, K.
登録日2015-04-10
公開日2015-05-27
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2.
J.Med.Chem., 58, 2015
8F6T
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BU of 8f6t by Molmil
Cryo-EM structure of alkane 1-monooxygenase AlkB-AlkG complex from Fontimonas thermophila
分子名称: Alkane 1-monooxygenase, DODECANE, FE (III) ION
著者Chai, J, Guo, G, McSweeney, S, Shanklin, J, Liu, Q.
登録日2022-11-17
公開日2023-04-05
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Structural basis for enzymatic terminal C-H bond functionalization of alkanes.
Nat.Struct.Mol.Biol., 30, 2023
8EF7
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BU of 8ef7 by Molmil
CryoEM of the soluble OPA1 dimer from the apo helical assembly on a lipid membrane
分子名称: Dynamin-like 120 kDa protein, form S1
著者Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E.
登録日2022-09-08
公開日2023-06-28
最終更新日2023-09-13
実験手法ELECTRON MICROSCOPY (9.68 Å)
主引用文献OPA1 helical structures give perspective to mitochondrial dysfunction.
Nature, 620, 2023
4CXP
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BU of 4cxp by Molmil
Structure of bifunctional endonuclease (AtBFN2) from Arabidopsis thaliana in complex with sulfate
分子名称: ENDONUCLEASE 2, PENTAETHYLENE GLYCOL, SULFATE ION, ...
著者Yu, T.-F, Maestre-Reyna, M, Ko, C.-Y, Ko, T.-P, Sun, Y.-J, Lin, T.-Y, Shaw, J.-F, Wang, A.H.-J.
登録日2014-04-08
公開日2014-07-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Structural Insights of the Ssdna Binding Site in the Multifunctional Endonuclease Atbfn2 from Arabidopsis Thaliana.
Plos One, 9, 2014
4CWM
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BU of 4cwm by Molmil
High-glycosylation crystal structure of the bifunctional endonuclease (AtBFN2) from Arabidopsis thaliana
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDONUCLEASE 2, ZINC ION, ...
著者Yu, T.-F, Maestre-Reyna, M, Ko, C.-Y, Ko, T.-P, Sun, Y.-J, Lin, T.-Y, Shaw, J.-F, Wang, A.H.-J.
登録日2014-04-03
公開日2014-07-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structural Insights of the Ssdna Binding Site in the Multifunctional Endonuclease Atbfn2 from Arabidopsis Thaliana.
Plos One, 9, 2014
4CXO
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bifunctional endonuclease in complex with ssDNA
分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ENDONUCLEASE 2, SULFATE ION, ...
著者Yu, T.-F, Maestre-Reyna, M, Ko, C.-Y, Ko, T.-P, Sun, Y.-J, Lin, T.-Y, Shaw, J.-F, Wang, A.H.-J.
登録日2014-04-08
公開日2014-07-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Structural Insights of the Ssdna Binding Site in the Multifunctional Endonuclease Atbfn2 from Arabidopsis Thaliana.
Plos One, 9, 2014
4CXV
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Structure of bifunctional endonuclease (AtBFN2) in complex with phosphate.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDONUCLEASE 2, ...
著者Yu, T.-F, Maestre-Reyna, M, Ko, C.-Y, Ko, T.-P, Sun, Y.-J, Lin, T.-Y, Shaw, J.-F, Wang, A.H.-J.
登録日2014-04-09
公開日2014-07-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Insights of the Ssdna Binding Site in the Multifunctional Endonuclease Atbfn2 from Arabidopsis Thaliana.
Plos One, 9, 2014
1NJS
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human GAR Tfase in complex with hydrolyzed form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid
分子名称: N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID, PHOSPHATE ION, Phosphoribosylglycinamide formyltransferase
著者Zhang, Y, Desharnais, J, Marsilje, T.H, Li, C, Hedrick, M.P, Gooljarsingh, L.T, Tavassoli, A, Benkovic, S.J, Olson, A.J, Boger, D.L, Wilson, I.A.
登録日2003-01-02
公開日2003-06-10
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Rational Design, Synthesis, Evaluation, and Crystal Structure of a Potent Inhibitor of Human GAR Tfase: 10-(Trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic Acid
Biochemistry, 42, 2003
1BBC
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BU of 1bbc by Molmil
STRUCTURE OF RECOMBINANT HUMAN RHEUMATOID ARTHRITIC SYNOVIAL FLUID PHOSPHOLIPASE A2 AT 2.2 ANGSTROMS RESOLUTION
分子名称: PHOSPHOLIPASE A2
著者Wery, J.-P, Schevitz, R.W, Clawson, D.K, Bobbitt, J.L, Dow, E.R, Gamboa, G, Goodsonjunior, T, Hermann, R.B, Kramer, R.M, Mcclure, D.B, Mihelich, E.D, Putnam, J.E, Sharp, J.D, Stark, D.H, Teater, C, Warrick, M.W, Jones, N.D.
登録日1992-05-04
公開日1993-10-31
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution.
Nature, 352, 1991
5W0N
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Structure of human TUT7 catalytic module (CM) in complex with UMPNPP and U2 RNA
分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, IODIDE ION, MAGNESIUM ION, ...
著者Faehnle, C.R, Walleshauser, J, Joshua-Tor, L.
登録日2017-05-31
公開日2017-06-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.497 Å)
主引用文献Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Nat. Struct. Mol. Biol., 24, 2017
3FPR
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BU of 3fpr by Molmil
Crystal Structure of Evasin-1
分子名称: Evasin-1
著者Dias, J.M, Shaw, J.P.
登録日2009-01-06
公開日2010-01-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural basis of chemokine sequestration by a tick chemokine binding protein: the crystal structure of the complex between Evasin-1 and CCL3
Plos One, 4, 2009

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