3ZBX

X-ray Structure of c-Met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline.

Summary for 3ZBX

Entry DOI	10.2210/pdb3zbx/pdb
Descriptor	HEPATOCYTE GROWTH FACTOR RECEPTOR, 6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline (3 entities in total)
Functional Keywords	transferase, inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	35235.77
Authors	McTigue, M.,Wickersham, J.,Ryan, K. (deposition date: 2012-11-13, release date: 2013-11-27, Last modification date: 2023-12-20)
Primary citation	Cui, J.J.,Shen, H.,Tran-Dube, M.,Nambu, M.,Mctigue, M.,Grodsky, N.,Ryan, K.,Yamazaki, S.,Aguirre, S.,Parker, M.,Li, Q.,Zou, H.,Christensen, J. Lessons from (S)-6-(1-(6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2, 4]Triazolo[4,3-B]Pyridazin-3-Yl)Ethyl)Quinoline (Pf-04254644), an Inhibitor of Receptor Tyrosine Kinase C-met with High Protein Kinase Selectivity But Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats. J.Med.Chem., 56:6651-, 2013 Cited by PubMed: 23944843 DOI: 10.1021/JM400926X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation