Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 107 件
6S70
DownloadVisualize
BU of 6s70 by Molmil
Crystal structure of CARM1 in complex with inhibitor UM251
分子名称: 1-[5-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]pentyl]guanidine, GLYCEROL, Histone-arginine methyltransferase CARM1
著者Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I.
登録日2019-07-04
公開日2020-03-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4).
Biochem.J., 477, 2020
6S74
DownloadVisualize
BU of 6s74 by Molmil
Crystal structure of CARM1 in complex with inhibitor UM305
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyrimidin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol, GLYCEROL, Histone-arginine methyltransferase CARM1
著者Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I.
登録日2019-07-04
公開日2020-03-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4).
Biochem.J., 477, 2020
6S77
DownloadVisualize
BU of 6s77 by Molmil
Crystal structure of CARM1 N265Y mutant in complex with inhibitor AA183
分子名称: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid, Histone-arginine methyltransferase CARM1
著者Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I.
登録日2019-07-04
公開日2020-03-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4).
Biochem.J., 477, 2020
3L0K
DownloadVisualize
BU of 3l0k by Molmil
Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP
分子名称: 6-acetyluridine 5'-phosphate, GLYCEROL, Uridine 5'-monophosphate synthase
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2009-12-10
公開日2010-01-26
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3L0N
DownloadVisualize
BU of 3l0n by Molmil
Human orotidyl-5'-monophosphate decarboxylase in complex with 6-mercapto-UMP
分子名称: 6-sulfanyluridine-5'-phosphate, Uridine 5'-monophosphate synthase
著者Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M.
登録日2009-12-10
公開日2010-01-26
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
5A0B
DownloadVisualize
BU of 5a0b by Molmil
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
分子名称: (4R)-4-(4-cyanophenyl)-6-methyl-2-oxidanylidene-3-[2-oxidanylidene-2-(4-propan-2-ylpiperazin-1-yl)ethyl]-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidine-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
著者vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A.
登録日2015-04-17
公開日2015-08-19
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
ChemMedChem, 10, 2015
5A0C
DownloadVisualize
BU of 5a0c by Molmil
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
分子名称: (6S)-6-(4-cyano-2-methylsulfonyl-phenyl)-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carbonitrile, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A.
登録日2015-04-17
公開日2015-08-19
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
ChemMedChem, 10, 2015
5A09
DownloadVisualize
BU of 5a09 by Molmil
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
分子名称: 2-[(4R)-4-(4-cyanophenyl)-5-ethanoyl-6-methyl-2-oxidanylidene-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidin-3-yl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, NEUTROPHIL ELASTASE, ...
著者vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A.
登録日2015-04-17
公開日2015-08-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
ChemMedChem, 10, 2015
5A0A
DownloadVisualize
BU of 5a0a by Molmil
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-[(6R)-5-ethanoyl-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile, ...
著者vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A.
登録日2015-04-17
公開日2015-08-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
ChemMedChem, 10, 2015
3JRY
DownloadVisualize
BU of 3jry by Molmil
Human Serum albumin with bound Sulfate
分子名称: SULFATE ION, Serum albumin
著者Hein, K.L, Kragh-Hansen, U, Morth, J.P, Nissen, P.
登録日2009-09-09
公開日2010-04-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin.
J.Struct.Biol., 171, 2010
3JQZ
DownloadVisualize
BU of 3jqz by Molmil
Crystal Structure of Human serum albumin complexed with Lidocaine
分子名称: 2-(diethylamino)-N-(2,6-dimethylphenyl)ethanamide, Serum albumin
著者Hein, K.L, Kragh-Hansen, U, Morth, J.P, Nissen, P.
登録日2009-09-08
公開日2010-04-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin.
J.Struct.Biol., 2010
2IT8
DownloadVisualize
BU of 2it8 by Molmil
Solution structure of a linear analog of the cyclic squash trypsin inhibitor MCoTI-II
分子名称: Trypsin inhibitor 2
著者Avrutina, O, Chiche, L, Diederichsen, U, Heitz, A, Kolmar, H.
登録日2006-10-19
公開日2007-10-02
最終更新日2014-04-02
実験手法SOLUTION NMR
主引用文献Knottin cyclization: Structure and stability of cyclic and linear squash inhibitors do not differ significantly
To be Published
3EX3
DownloadVisualize
BU of 3ex3 by Molmil
human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct
分子名称: GLYCEROL, Orotidine-5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3EWX
DownloadVisualize
BU of 3ewx by Molmil
K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, degraded to BMP
分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine-5'-phosphate decarboxylase
著者Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
2XHN
DownloadVisualize
BU of 2xhn by Molmil
Rhamnogalacturonan lyase from Aspergillus aculeatus K150A active site mutant
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, RHAMNOGALACTURONASE B, ...
著者Jensen, M.H, Otten, H, Christensen, U, Borchert, T.V, Christensen, L.L.H, Larsen, S, Lo Leggio, L.
登録日2010-06-18
公開日2010-09-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Structural and Biochemical Studies Elucidate the Mechanism of Rhamnogalacturonan Lyase from Aspergillus Aculeatus.
J.Mol.Biol., 404, 2010
1XS6
DownloadVisualize
BU of 1xs6 by Molmil
dCTP deaminase from Escherichia coli. E138A mutant enzyme in complex with dUTP
分子名称: DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION
著者Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M.
登録日2004-10-18
公開日2004-12-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
3EX4
DownloadVisualize
BU of 3ex4 by Molmil
human orotidyl-5'-monophosphate decarboxylase in complex with BMP
分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine-5'-phosphate decarboxylase
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
1XS1
DownloadVisualize
BU of 1xs1 by Molmil
dCTP deaminase from Escherichia coli in complex with dUTP
分子名称: DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION
著者Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M.
登録日2004-10-18
公開日2004-12-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
3EWU
DownloadVisualize
BU of 3ewu by Molmil
D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP, covalent adduct
分子名称: 6-ethyluridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ...
著者Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
1XS4
DownloadVisualize
BU of 1xs4 by Molmil
dCTP deaminase from Escherichia coli- E138A mutant enzyme in complex with dCTP
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION
著者Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M.
登録日2004-10-18
公開日2004-12-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
3EWY
DownloadVisualize
BU of 3ewy by Molmil
K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with OMP, decarboxylated to UMP
分子名称: GLYCEROL, Orotidine-5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3EX2
DownloadVisualize
BU of 3ex2 by Molmil
human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP
分子名称: 6-cyanouridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3EWW
DownloadVisualize
BU of 3eww by Molmil
D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP, covalent adduct
分子名称: 6-[(E)-iminomethyl]uridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase
著者Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3EWZ
DownloadVisualize
BU of 3ewz by Molmil
human orotidyl-5'-monophosphate decarboxylase in complex with 5-cyano-UMP
分子名称: 5-CYANO-URIDINE-5'-MONOPHOSPHATE, Orotidine-5'-phosphate decarboxylase, SULFATE ION
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3EX6
DownloadVisualize
BU of 3ex6 by Molmil
D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct
分子名称: CHLORIDE ION, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ...
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009

224201

件を2024-08-28に公開中

PDB statisticsPDBj update infoContact PDBjnumon