6S74
Crystal structure of CARM1 in complex with inhibitor UM305
Summary for 6S74
| Entry DOI | 10.2210/pdb6s74/pdb |
| Descriptor | Histone-arginine methyltransferase CARM1, (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyrimidin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | inhibitor, complex, arginine methyltransferase, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 162204.29 |
| Authors | Gunnell, E.A.,Muhsen, U.,Dowden, J.,Dreveny, I. (deposition date: 2019-07-04, release date: 2020-03-04, Last modification date: 2020-03-11) |
| Primary citation | Gunnell, E.A.,Al-Noori, A.,Muhsen, U.,Davies, C.C.,Dowden, J.,Dreveny, I. Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477:787-800, 2020 Cited by PubMed: 32011657DOI: 10.1042/BCJ20190826 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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