6S77
Crystal structure of CARM1 N265Y mutant in complex with inhibitor AA183
Summary for 6S77
| Entry DOI | 10.2210/pdb6s77/pdb |
| Descriptor | Histone-arginine methyltransferase CARM1, (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid (3 entities in total) |
| Functional Keywords | inhibitor, complex, arginine methyltransferase, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 162296.38 |
| Authors | Gunnell, E.A.,Muhsen, U.,Dowden, J.,Dreveny, I. (deposition date: 2019-07-04, release date: 2020-03-04, Last modification date: 2020-03-11) |
| Primary citation | Gunnell, E.A.,Al-Noori, A.,Muhsen, U.,Davies, C.C.,Dowden, J.,Dreveny, I. Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477:787-800, 2020 Cited by PubMed: 32011657DOI: 10.1042/BCJ20190826 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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