7QXS
 
 | | Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains) | | Descriptor: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | Authors: | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | Deposit date: | 2022-01-27 | | Release date: | 2022-03-02 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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7QXA
 | | Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened) | | Descriptor: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | Authors: | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | Deposit date: | 2022-01-26 | | Release date: | 2022-03-02 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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7QXB
 | | Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map) | | Descriptor: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | Authors: | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | Deposit date: | 2022-01-26 | | Release date: | 2022-03-02 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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9QAZ
 | | Catalytic core 2 of dimeric human telomerase | | Descriptor: | Adrenocortical dysplasia protein homolog, DNA (5'-D(P*GP*TP*TP*AP*GP*GP*G)-3'), Histone H2A, ... | | Authors: | Balch, S, Sekne, Z, Franco-Echevarria, E, Ludzia, P, Kretsch, R.C, Sun, W, Yu, H, Ghanim, G.E, Sigurdur, T.R, Ding, Y, Das, R, Nguyen, T.H.D. | | Deposit date: | 2025-02-28 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Science, 389, 2025
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9QB2
 | | H/ACA RNP protomer of human telomerase dimer | | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | Authors: | Balch, S, Sekne, Z, Franco-Echevarria, E, Ludzia, P, Kretsch, R.C, Sun, W, Yu, H, Ghanim, G.E, Sigurdur, T.R, Ding, Y, Das, R, Nguyen, T.H.D. | | Deposit date: | 2025-02-28 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Science, 389, 2025
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9QAY
 | | Catalytic core 1 of dimeric human telomerase | | Descriptor: | Adrenocortical dysplasia protein homolog, DNA (5'-D(P*GP*TP*TP*AP*GP*GP*G)-3'), Histone H2A, ... | | Authors: | Balch, S, Sekne, Z, Franco-Echevarria, E, Ludzia, P, Kretsch, R.C, Sun, W, Yu, H, Ghanim, G.E, Sigurdur, T.R, Ding, Y, Das, R, Nguyen, T.H.D. | | Deposit date: | 2025-02-28 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Science, 389, 2025
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8OUE
 | | The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in a semi-closed conformation | | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | Authors: | Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D. | | Deposit date: | 2023-04-22 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | 2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Nat Commun, 15, 2024
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8OUF
 | | The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in an open conformation | | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | Authors: | Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D. | | Deposit date: | 2023-04-22 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | 2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Nat Commun, 15, 2024
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9QB3
 | | Dimer structure of H/ACA RNP lobe of human telomerase | | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | Authors: | Balch, S, Sekne, Z, Franco-Echevarria, E, Ludzia, P, Kretsch, R.C, Sun, W, Yu, H, Ghanim, G.E, Sigurdur, T.R, Ding, Y, Das, R, Nguyen, T.H.D. | | Deposit date: | 2025-02-28 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Science, 389, 2025
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9QAX
 | | The catalytic core with C2 symmetry of human telomerase dimer | | Descriptor: | Adrenocortical dysplasia protein homolog, DNA (5'-D(P*GP*TP*TP*AP*GP*GP*G)-3'), Histone H2A, ... | | Authors: | Balch, S, Sekne, Z, Franco-Echevarria, E, Ludzia, P, Kretsch, R.C, Sun, W, Yu, H, Ghanim, G.E, Sigurdur, T.R, Ding, Y, Das, R, Nguyen, T.H.D. | | Deposit date: | 2025-02-28 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Science, 389, 2025
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