6BDZ
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![BU of 6bdz by Molmil](/molmil-images/mine/6bdz) | ADAM10 Extracellular Domain Bound by the 11G2 Fab | Descriptor: | 11G2 Fab Heavy Chain, 11G2 Fab Light Chain, CALCIUM ION, ... | Authors: | Seegar, T.C.M. | Deposit date: | 2017-10-24 | Release date: | 2017-12-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10. Cell, 171, 2017
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6BE6
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![BU of 6be6 by Molmil](/molmil-images/mine/6be6) | ADAM10 Extracellular Domain | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 10, SULFATE ION, ... | Authors: | Seegar, T.C.M. | Deposit date: | 2017-10-24 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10. Cell, 171, 2017
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6UFY
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![BU of 6ufy by Molmil](/molmil-images/mine/6ufy) | B. theta Bile Salt Hydrolase | Descriptor: | Choloylglycine hydrolase | Authors: | Seegar, T.C.M. | Deposit date: | 2019-09-25 | Release date: | 2020-02-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat.Chem.Biol., 16, 2020
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6UH4
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![BU of 6uh4 by Molmil](/molmil-images/mine/6uh4) | B. theta Bile Salt Hydrolase with covalent inhibitor | Descriptor: | (5R,6R)-6-[(1S,2R,4aS,4bS,7R,8aS,10R,10aS)-7,10-dihydroxy-1,2,4b-trimethyltetradecahydrophenanthren-2-yl]-5-methylheptan-2-one, Choloylglycine hydrolase | Authors: | Seegar, T.C.M. | Deposit date: | 2019-09-26 | Release date: | 2020-02-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat.Chem.Biol., 16, 2020
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7RCT
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![BU of 7rct by Molmil](/molmil-images/mine/7rct) | |
5TCX
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![BU of 5tcx by Molmil](/molmil-images/mine/5tcx) | Crystal structure of human tetraspanin CD81 | Descriptor: | CD81 antigen, CHOLESTEROL | Authors: | Zimmerman, B, McMillan, B.J, Seegar, T.C.M, Kruse, A.C, Blacklow, S.C. | Deposit date: | 2016-09-16 | Release date: | 2016-11-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell, 167, 2016
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6PY8
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![BU of 6py8 by Molmil](/molmil-images/mine/6py8) | Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA | Descriptor: | DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ... | Authors: | Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C. | Deposit date: | 2019-07-29 | Release date: | 2019-08-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.75 Å) | Cite: | Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci.Signal., 12, 2019
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5VO5
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![BU of 5vo5 by Molmil](/molmil-images/mine/5vo5) | |
6NCE
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![BU of 6nce by Molmil](/molmil-images/mine/6nce) | Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead DNA sequence | Descriptor: | DNA (5'-D(*AP*CP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), Forkhead box protein N3, ... | Authors: | Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L. | Deposit date: | 2018-12-11 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.598 Å) | Cite: | Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol. Cell, 74, 2019
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6NCM
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![BU of 6ncm by Molmil](/molmil-images/mine/6ncm) | Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead-like (FHL) DNA sequence | Descriptor: | DNA (5'-D(*AP*TP*AP*GP*CP*GP*TP*CP*TP*TP*AP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*CP*TP*AP*AP*GP*AP*CP*GP*CP*TP*A)-3'), Forkhead box protein N3, ... | Authors: | Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L. | Deposit date: | 2018-12-11 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol. Cell, 74, 2019
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6U9S
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![BU of 6u9s by Molmil](/molmil-images/mine/6u9s) | Crystal structure of human CD81 large extracellular loop in complex with 5A6 Fab | Descriptor: | 5A6 FAB Heavy Chain, 5A6 FAB Light Chain, CD81 antigen, ... | Authors: | Susa, K.J, Seegar, T.C.M, Blacklow, S.C.B, Kruse, A.C. | Deposit date: | 2019-09-09 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife, 9, 2020
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4JYO
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![BU of 4jyo by Molmil](/molmil-images/mine/4jyo) | Structural basis for angiopoietin-1 mediated signaling initiation | Descriptor: | Angiopoietin-1, CALCIUM ION | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-03-31 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JZC
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![BU of 4jzc by Molmil](/molmil-images/mine/4jzc) | Angiopoietin-2 fibrinogen domain TAG mutant | Descriptor: | Angiopoietin-2 | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-04-02 | Release date: | 2013-05-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4K0V
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![BU of 4k0v by Molmil](/molmil-images/mine/4k0v) | Structural basis for angiopoietin-1 mediated signaling initiation | Descriptor: | Angiopoietin-1, TEK tyrosine kinase variant | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-04-04 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.51 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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7RDB
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![BU of 7rdb by Molmil](/molmil-images/mine/7rdb) | Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) | Descriptor: | Tetraspanin-15 | Authors: | Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C. | Deposit date: | 2021-07-09 | Release date: | 2021-11-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure, 30, 2022
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7RD5
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![BU of 7rd5 by Molmil](/molmil-images/mine/7rd5) | Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) in complex with 1C12 Fab | Descriptor: | 1C12 Fab Heavy Chain, 1C12 Fab Light Chain, Tetraspanin-15 | Authors: | Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C. | Deposit date: | 2021-07-09 | Release date: | 2021-11-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure, 30, 2022
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