7RCT

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor RMC-4550

Summary for 7RCT

Entry DOI	10.2210/pdb7rct/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 11, {3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl}methanol, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	shp2 rmc-4550 phosphatase, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	121441.55
Authors	Seegar, T.C.M. (deposition date: 2021-07-08, release date: 2021-09-01, Last modification date: 2023-10-18)
Primary citation	Vemulapalli, V.,Donovan, K.A.,Seegar, T.C.M.,Rogers, J.M.,Bae, M.,Lumpkin, R.J.,Cao, R.,Henke, M.T.,Ray, S.S.,Fischer, E.S.,Cuny, G.D.,Blacklow, S.C. Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry, 60:2593-2609, 2021 Cited by PubMed: 34411482 DOI: 10.1021/acs.biochem.1c00377 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation