7RCT

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor RMC-4550

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation
B	0004725	molecular_function	protein tyrosine phosphatase activity
B	0006470	biological_process	protein dephosphorylation
B	0016311	biological_process	dephosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG

Chain	Residue	Details
B	VAL457-GLY467

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Phosphocysteine intermediate

Chain	Residue	Details
A	CYS459
B	CYS459

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	CYS459
A	GLN506
B	GLN506
A	ASP425
B	ASP425
B	CYS459

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	THR2
B	THR2

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	TYR62
B	TYR62

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P35235

Chain	Residue	Details
B	TYR66
A	TYR66

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