6GTM
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![BU of 6gtm by Molmil](/molmil-images/mine/6gtm) | Crystal structure of SmbA in complex with ppGpp. | Descriptor: | GUANOSINE-5',3'-TETRAPHOSPHATE, SmbA | Authors: | Dubey, B.N, Schirmer, T. | Deposit date: | 2018-06-18 | Release date: | 2019-07-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus Nat Microbiol, 2021
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5CMT
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5CGL
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5CKL
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4XJY
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![BU of 4xjy by Molmil](/molmil-images/mine/4xjy) | Periplasmic repressor protein YfiR | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, L(+)-TARTARIC ACID, YfiR | Authors: | Kauer, S, Schirmer, T. | Deposit date: | 2015-01-09 | Release date: | 2016-01-20 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Periplasmic repressor protein YfiR at 1.8 Angstroms resolution To Be Published
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6ZXM
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![BU of 6zxm by Molmil](/molmil-images/mine/6zxm) | Diguanylate cyclase DgcR in complex with c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, Putative GGDEF/response regulator receiver domain protein | Authors: | Teixeira, R.D, Schirmer, T. | Deposit date: | 2020-07-29 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase. Nat Commun, 12, 2021
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6ZXC
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6QKI
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![BU of 6qki by Molmil](/molmil-images/mine/6qki) | Native structure of EgtB from Chloracidobacterium thermophilum, a type II sulfoxide synthase | Descriptor: | FE (III) ION, Uncharacterized protein | Authors: | Stampfli, A.R, Badri, B.N, Schirmer, T, Seebeck, F.P. | Deposit date: | 2019-01-29 | Release date: | 2019-03-27 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | An Alternative Active Site Architecture for O2Activation in the Ergothioneine Biosynthetic EgtB from Chloracidobacterium thermophilum. J.Am.Chem.Soc., 141, 2019
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6QKJ
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![BU of 6qkj by Molmil](/molmil-images/mine/6qkj) | EgtB from Chloracidobacterium thermophilum, a type II sulfoxide synthase in complex with N,N,N-trimethyl-histidine | Descriptor: | CHLORIDE ION, FE (III) ION, IMIDAZOLE, ... | Authors: | Stampfli, A.R, Badri, B.N, Schirmer, T, Seebeck, F.P. | Deposit date: | 2019-01-29 | Release date: | 2019-03-27 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | An Alternative Active Site Architecture for O2Activation in the Ergothioneine Biosynthetic EgtB from Chloracidobacterium thermophilum. J.Am.Chem.Soc., 141, 2019
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2OAT
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![BU of 2oat by Molmil](/molmil-images/mine/2oat) | ORNITHINE AMINOTRANSFERASE COMPLEXED WITH 5-FLUOROMETHYLORNITHINE | Descriptor: | 1-AMINO-7-(2-METHYL-3-OXIDO-5-((PHOSPHONOXY)METHYL)-4-PYRIDOXAL-5-OXO-6-HEPTENATE, ORNITHINE AMINOTRANSFERASE | Authors: | Storici, P, Schirmer, T. | Deposit date: | 1998-05-07 | Release date: | 1998-12-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine. J.Mol.Biol., 285, 1999
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1W25
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![BU of 1w25 by Molmil](/molmil-images/mine/1w25) | Response regulator PleD in complex with c-diGMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, STALKED-CELL DIFFERENTIATION CONTROLLING PROTEIN, ... | Authors: | Chan, C, Schirmer, T, Jenal, U. | Deposit date: | 2004-06-28 | Release date: | 2004-11-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis of Activity and Allosteric Control of Diguanylate Cyclase Proc.Natl.Acad.Sci.USA, 101, 2004
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6ZXB
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5IDM
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![BU of 5idm by Molmil](/molmil-images/mine/5idm) | Bifunctional histidine kinase CckA (domain, CA) in complex with c-di-GMP and AMPPNP/Mg2+ | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Cell cycle histidine kinase CckA, MAGNESIUM ION, ... | Authors: | Dubey, B.N, Schirmer, T. | Deposit date: | 2016-02-24 | Release date: | 2016-10-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Sci Adv, 2, 2016
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6SFT
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![BU of 6sft by Molmil](/molmil-images/mine/6sft) | Solution structure of protein ARR_CleD in complex with c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Two-component receiver protein CleD | Authors: | Habazettl, J, Hee, C.S, Jenal, U, Schirmer, T, Grzesiek, S. | Deposit date: | 2019-08-02 | Release date: | 2020-06-10 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP. Proc.Natl.Acad.Sci.USA, 117, 2020
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5JFF
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![BU of 5jff by Molmil](/molmil-images/mine/5jff) | E. coli EcFicT mutant G55R in complex with EcFicA | Descriptor: | CHLORIDE ION, Probable adenosine monophosphate-protein transferase fic, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, ... | Authors: | Stanger, F.V, Schirmer, T. | Deposit date: | 2016-04-19 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin. Plos One, 11, 2016
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5JFZ
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![BU of 5jfz by Molmil](/molmil-images/mine/5jfz) | E. coli EcFicT in complex with EcFicA mutant E28G | Descriptor: | Probable adenosine monophosphate-protein transferase fic, Uncharacterized protein YhfG | Authors: | Stanger, F.V, Schirmer, T. | Deposit date: | 2016-04-19 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin. Plos One, 11, 2016
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6TTR
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![BU of 6ttr by Molmil](/molmil-images/mine/6ttr) | Crystal Structure of the coiled coil and GGDEF domain of DgcB from Caulobacter crescentus in complex with c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), GGDEF diguanylate cyclase DgcB, PHOSPHATE ION | Authors: | Holzschuh, F, Schirmer, T, Teixeira, R.D. | Deposit date: | 2019-12-30 | Release date: | 2021-01-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal structure of the coiled coil and GGDEF domain of DgcB from Caulobacter crescentus in complex with c-di-GMP To Be Published
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6TTS
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![BU of 6tts by Molmil](/molmil-images/mine/6tts) | Crystal structure of the GGDEF domain of DgcB from Caulobacter crescentus in complex with c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), GGDEF diguanylate cyclase DgcB, SULFATE ION | Authors: | Holzschuh, F, Schirmer, T, Teixeira, R. | Deposit date: | 2019-12-30 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the GGDEF domain of DgcB from Caulobacter crescentus in complex with c-di-GMP To Be Published
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4H54
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![BU of 4h54 by Molmil](/molmil-images/mine/4h54) | Crystal structure of the diguanylate cyclase DgcZ | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Diguanylate cyclase YdeH, GUANOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ... | Authors: | Zaehringer, F, Schirmer, T. | Deposit date: | 2012-09-18 | Release date: | 2013-07-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Structure and signaling mechanism of a zinc-sensory diguanylate cyclase. Structure, 21, 2013
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3ZP9
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2J1N
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![BU of 2j1n by Molmil](/molmil-images/mine/2j1n) | osmoporin OmpC | Descriptor: | CHLORIDE ION, DODECANE, MAGNESIUM ION, ... | Authors: | Basle, A, Storici, P, Rummel, G, Rosenbusch, J.P, Schirmer, T. | Deposit date: | 2006-08-15 | Release date: | 2006-09-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Osmoporin Ompc from E. Coli at 2.0 A. J.Mol.Biol., 362, 2006
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1BLE
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4GJV
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![BU of 4gjv by Molmil](/molmil-images/mine/4gjv) | Streptavidin-S112H | Descriptor: | CHLORIDE ION, Rhodium, Streptavidin, ... | Authors: | Heinisch, T, Schirmer, T. | Deposit date: | 2012-08-10 | Release date: | 2013-02-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A dual anchoring strategy for the localization and activation of artificial metalloenzymes based on the biotin-streptavidin technology. J.Am.Chem.Soc., 135, 2013
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4GJS
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![BU of 4gjs by Molmil](/molmil-images/mine/4gjs) | Streptavidin-K121H | Descriptor: | Rhodium, Streptavidin, trichloro{(1,2,3,4,5-eta)-1,2,3,4-tetramethyl-5-[2-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)ethyl]cyclopentadienyl}rhodium(1+) | Authors: | Heinisch, T, Schirmer, T. | Deposit date: | 2012-08-10 | Release date: | 2013-02-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A dual anchoring strategy for the localization and activation of artificial metalloenzymes based on the biotin-streptavidin technology. J.Am.Chem.Soc., 135, 2013
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4LYK
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