6PIL
 
 | | Antibody scFv-M204 monomeric state | | Descriptor: | CHLORIDE ION, scFv-M204 antibody | | Authors: | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | | Deposit date: | 2019-06-26 | | Release date: | 2020-06-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J.Biol.Chem., 295, 2020
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6PQ5
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6PEO
 | | Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril | | Descriptor: | Alpha-synuclein | | Authors: | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | | Deposit date: | 2019-06-20 | | Release date: | 2019-11-27 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
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6PK8
 | | Antibody scFv-M204 dimeric state | | Descriptor: | SULFATE ION, scFv-M204 antibody | | Authors: | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | | Deposit date: | 2019-06-28 | | Release date: | 2020-06-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J.Biol.Chem., 295, 2020
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6PQA
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6PSC
 | | Antibody scFv-M204 trimeric state | | Descriptor: | scFv-M204 antibody | | Authors: | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | | Deposit date: | 2019-07-12 | | Release date: | 2020-06-17 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J.Biol.Chem., 295, 2020
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6O4J
 | | Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Griner, S.L, Sawaya, M.R, Rodriguez, J.A, Cascio, D, Gonen, T. | | Deposit date: | 2019-02-28 | | Release date: | 2019-10-30 | | Last modified: | 2024-10-23 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.402 Å) | | Cite: | Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau.
Elife, 8, 2019
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2QW7
 | | Carboxysome Subunit, CcmL | | Descriptor: | Carbon dioxide concentrating mechanism protein ccmL, GLYCEROL | | Authors: | Tanaka, S, Sawaya, M.R, Kerfeld, C.A, Yeates, T.O. | | Deposit date: | 2007-08-09 | | Release date: | 2008-03-04 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Atomic-level models of the bacterial carboxysome shell.
Science, 319, 2008
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2Z9H
 | | Ethanolamine utilization protein, EutN | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CHLORIDE ION, Ethanolamine utilization protein eutN | | Authors: | Tanaka, S, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2007-09-20 | | Release date: | 2007-10-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | The crystal structure of ethanolamine utilization protein EutN from E. coli
To be Published
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2RCF
 | | Carboxysome Shell protein, OrfA from H. Neapolitanus | | Descriptor: | CHLORIDE ION, GLYCEROL, Unidentified carboxysome polypeptide | | Authors: | Kerfeld, C.A, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2007-09-19 | | Release date: | 2008-04-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Atomic-level models of the bacterial carboxysome shell.
Science, 319, 2008
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2RIF
 | | CBS domain protein PAE2072 from Pyrobaculum aerophilum complexed with AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, CESIUM ION, Conserved protein with 2 CBS domains | | Authors: | Lee, T.M, King, N.P, Sawaya, M.R, Cascio, D, Yeates, T.O. | | Deposit date: | 2007-10-10 | | Release date: | 2008-06-17 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structures and Functional Implications of an AMP-Binding Cystathionine beta-Synthase Domain Protein from a Hyperthermophilic Archaeon.
J.Mol.Biol., 380, 2008
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2RIH
 | | CBS domain protein PAE2072 from Pyrobaculum aerophilum | | Descriptor: | ACETIC ACID, Conserved protein with 2 CBS domains, SULFATE ION | | Authors: | Lee, T.M, King, N.P, Sawaya, M.R, Cascio, D, Yeates, T.O. | | Deposit date: | 2007-10-10 | | Release date: | 2008-06-17 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures and Functional Implications of an AMP-Binding Cystathionine beta-Synthase Domain Protein from a Hyperthermophilic Archaeon
J.Mol.Biol., 380, 2008
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2Y29
 | | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph III | | Descriptor: | AMYLOID BETA A4 PROTEIN | | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | Deposit date: | 2010-12-14 | | Release date: | 2011-10-26 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y5Y
 | | Crystal structure of LacY in complex with an affinity inactivator | | Descriptor: | 2-sulfanylethyl beta-D-galactopyranoside, BARIUM ION, LACTOSE PERMEASE | | Authors: | Chaptal, V, Kwon, S, Sawaya, M.R, Guan, L, Kaback, H.R, Abramson, J. | | Deposit date: | 2011-01-19 | | Release date: | 2011-06-15 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.38 Å) | | Cite: | Crystal Structure of Lactose Permease in Complex with an Affinity Inactivator Yields Unique Insight Into Sugar Recognition.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y3L
 | | Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 2 | | Descriptor: | AMYLOID BETA A4 PROTEIN | | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | Deposit date: | 2010-12-21 | | Release date: | 2011-11-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y3K
 | | Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 1 | | Descriptor: | AMYLOID BETA A4 PROTEIN | | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | Deposit date: | 2010-12-21 | | Release date: | 2011-11-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y3J
 | | Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35) | | Descriptor: | AMYLOID BETA A4 PROTEIN | | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | Deposit date: | 2010-12-21 | | Release date: | 2011-11-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y2A
 | | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I | | Descriptor: | ACETATE ION, AMYLOID BETA A4 PROTEIN | | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | Deposit date: | 2010-12-14 | | Release date: | 2011-10-26 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
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8UMP
 | | T33-ml35 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | Descriptor: | T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold | | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2023-10-18 | | Release date: | 2023-11-15 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UF0
 | | T33-ml23 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | Descriptor: | T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold | | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2023-10-03 | | Release date: | 2023-11-15 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.02 Å) | | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8V9O
 | | Imaging scaffold engineered to bind the therapeutic protein target BARD1 | | Descriptor: | CALCIUM ION, Tetrahedral Nanocage Cage Component Fused to Anti-BARD1 Darpin, Tetrahedral Nanocage Cage, ... | | Authors: | Agdanowski, M.P, Castells-Graells, R, Sawaya, M.R, Yeates, T.O, Arbing, M.A. | | Deposit date: | 2023-12-08 | | Release date: | 2024-05-15 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (3.81 Å) | | Cite: | X-ray crystal structure of a designed rigidified imaging scaffold in the ligand-free conformation.
Acta Crystallogr.,Sect.F, 80, 2024
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8UI2
 | | T33-ml28 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | Descriptor: | T33-ml28-redesigned-CutA-fold, T33-ml28-redesigned-tandem-BMC-T-fold | | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2023-10-09 | | Release date: | 2024-03-06 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UKM
 | | T33-ml30 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | Descriptor: | T33-ml30-redesigned-4-OT-fold, T33-ml30-redesigned-tandem-BMC-T-fold | | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2023-10-14 | | Release date: | 2024-03-06 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UN1
 | | T33-ml23 Assembly Intermediate - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | Descriptor: | T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold | | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2023-10-18 | | Release date: | 2024-03-06 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UMR
 | | T33-ml35 Assembly Intermediate - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | Descriptor: | T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold | | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2023-10-18 | | Release date: | 2024-03-06 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (4.42 Å) | | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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