1K4Q
| Human Glutathione Reductase Inactivated by Peroxynitrite | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione Reductase | Authors: | Savvides, S.N, Scheiwein, M, Boehme, C.C, Arteel, G.E, Karplus, P.A, Becker, K, Schirmer, R.H. | Deposit date: | 2001-10-08 | Release date: | 2002-01-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J.Biol.Chem., 277, 2002
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1OPX
| Crystal structure of the traffic ATPase (HP0525) of the Helicobacter pylori type IV secretion system bound by sulfate | Descriptor: | NONAETHYLENE GLYCOL, SULFATE ION, virB11 homolog | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | Deposit date: | 2003-03-06 | Release date: | 2003-05-06 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion Embo J., 22, 2003
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1NLZ
| Crystal structure of unliganded traffic ATPase of the type IV secretion system of helicobacter pylori | Descriptor: | virB11 homolog | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | Deposit date: | 2003-01-08 | Release date: | 2003-05-06 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion Embo J., 22, 2003
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1NLY
| Crystal structure of the traffic ATPase of the Helicobacter pylori type IV secretion system in complex with ATPgammaS | Descriptor: | MAGNESIUM ION, NONAETHYLENE GLYCOL, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | Deposit date: | 2003-01-08 | Release date: | 2003-05-06 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion Embo J., 22, 2003
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1SRU
| Crystal structure of full length E. coli SSB protein | Descriptor: | Single-strand binding protein | Authors: | Savvides, S.N, Raghunathan, S, Fuetterer, K, Kozlov, A.G, Lohman, T.M, Waksman, G. | Deposit date: | 2004-03-23 | Release date: | 2004-08-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA. Protein Sci., 13, 2004
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1XAN
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1ETE
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2GOU
| Structure of wild type, oxidized SYE1, an OYE homologue from S. oneidensis | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FLAVIN MONONUCLEOTIDE, ... | Authors: | Savvides, S.N, van den Hemel, D. | Deposit date: | 2006-04-14 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. J.Biol.Chem., 281, 2006
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2GQA
| Structure of NADH-reduced SYE1, an OYE homologue from S. oneidensis | Descriptor: | FLAVIN MONONUCLEOTIDE, SULFATE ION, oxidoreductase, ... | Authors: | Savvides, S.N, van den Hemel, D. | Deposit date: | 2006-04-20 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. J.Biol.Chem., 281, 2006
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2GQ9
| Structure of SYE1, an OYE homologue from S. oneidensis, in complex with p-hydroxybenzaldehyde | Descriptor: | FLAVIN MONONUCLEOTIDE, P-HYDROXYBENZALDEHYDE, SULFATE ION, ... | Authors: | Savvides, S.N, van den Hemel, D. | Deposit date: | 2006-04-20 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. J.Biol.Chem., 281, 2006
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2I9V
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2GQ8
| Structure of SYE1, an OYE homologue from S. ondeidensis, in complex with p-hydroxyacetophenone | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FLAVIN MONONUCLEOTIDE, P-HYDROXYACETOPHENONE, ... | Authors: | Savvides, S.N, van den Hemel, D. | Deposit date: | 2006-04-20 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. J.Biol.Chem., 281, 2006
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7OX6
| Solution structure of human interleukin-9 | Descriptor: | Interleukin-9 | Authors: | Savvides, S.N, Tripsianes, K, De Vos, T, Papageorgiou, A, Evangelidis, T. | Deposit date: | 2021-06-22 | Release date: | 2022-12-28 | Last modified: | 2024-11-06 | Method: | SOLUTION NMR | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9) Biorxiv, 2022
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8QMG
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7R3N
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8AVB
| Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model). | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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7AL7
| The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18, Interleukin-18-binding protein | Authors: | Detry, S, Andries, J, Bloch, Y, Clancy, D, Savvides, S.N. | Deposit date: | 2020-10-05 | Release date: | 2022-04-20 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. J.Biol.Chem., 298, 2022
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4WRL
| Structure of the human CSF-1:CSF-1R complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor, ... | Authors: | Felix, J, De Munck, S, Elegheert, J, Savvides, S.N. | Deposit date: | 2014-10-24 | Release date: | 2015-08-12 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.802 Å) | Cite: | Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure, 23, 2015
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4WRM
| Structure of the human CSF-1:CSF-1R complex | Descriptor: | Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor | Authors: | Felix, J, De Munck, S, Elegheert, J, Savvides, S.N. | Deposit date: | 2014-10-24 | Release date: | 2015-08-12 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (6.853 Å) | Cite: | Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure, 23, 2015
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5D28
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5D22
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2NNC
| Structure of the sulfur carrier protein SoxY from Chlorobium limicola f thiosulfatophilum | Descriptor: | CHLORIDE ION, NITROGEN MOLECULE, PHOSPHATE ION, ... | Authors: | Stout, J, Van Driessche, G, Savvides, S.N, Van Beeumen, J. | Deposit date: | 2006-10-24 | Release date: | 2007-03-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | X-ray crystallographic analysis of the sulfur carrier protein SoxY from Chlorobium limicola f. thiosulfatophilum reveals a tetrameric structure. Protein Sci., 16, 2007
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2NNF
| Structure of the sulfur carrier protein SoxY from Chlorobium limicola f thiosulfatophilum | Descriptor: | PHOSPHATE ION, Sulfur covalently-binding protein | Authors: | Stout, J, Van Driessche, G, Savvides, S.N, Van Beeumen, J. | Deposit date: | 2006-10-24 | Release date: | 2007-03-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | X-ray crystallographic analysis of the sulfur carrier protein SoxY from Chlorobium limicola f. thiosulfatophilum reveals a tetrameric structure. Protein Sci., 16, 2007
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4NN6
| Cytokine receptor complex - Crystal form 1B | Descriptor: | Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, Thymic stromal lymphopoietin | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | Deposit date: | 2013-11-16 | Release date: | 2014-03-19 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2.545 Å) | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat.Struct.Mol.Biol., 21, 2014
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4NN5
| Cytokine receptor complex - Crystal form 1A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Cytokine receptor-like factor 2, ... | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | Deposit date: | 2013-11-16 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat.Struct.Mol.Biol., 21, 2014
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