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PDB: 132 results

1K4Q
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Human Glutathione Reductase Inactivated by Peroxynitrite
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Glutathione Reductase
Authors:Savvides, S.N, Scheiwein, M, Boehme, C.C, Arteel, G.E, Karplus, P.A, Becker, K, Schirmer, R.H.
Deposit date:2001-10-08
Release date:2002-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite.
J.Biol.Chem., 277, 2002
1SRU
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Crystal structure of full length E. coli SSB protein
Descriptor: Single-strand binding protein
Authors:Savvides, S.N, Raghunathan, S, Fuetterer, K, Kozlov, A.G, Lohman, T.M, Waksman, G.
Deposit date:2004-03-23
Release date:2004-08-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA.
Protein Sci., 13, 2004
1OPX
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Crystal structure of the traffic ATPase (HP0525) of the Helicobacter pylori type IV secretion system bound by sulfate
Descriptor: NONAETHYLENE GLYCOL, SULFATE ION, virB11 homolog
Authors:Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G.
Deposit date:2003-03-06
Release date:2003-05-06
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion
Embo J., 22, 2003
1NLZ
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Crystal structure of unliganded traffic ATPase of the type IV secretion system of helicobacter pylori
Descriptor: virB11 homolog
Authors:Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G.
Deposit date:2003-01-08
Release date:2003-05-06
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion
Embo J., 22, 2003
1NLY
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Crystal structure of the traffic ATPase of the Helicobacter pylori type IV secretion system in complex with ATPgammaS
Descriptor: MAGNESIUM ION, NONAETHYLENE GLYCOL, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G.
Deposit date:2003-01-08
Release date:2003-05-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion
Embo J., 22, 2003
1ETE
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CRYSTAL STRUCTURE OF THE FLT3 LIGAND
Descriptor: FLT3 LIGAND, ZINC ION
Authors:Savvides, S.N, Boone, T, Karplus, P.A.
Deposit date:2000-04-12
Release date:2000-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
Nat.Struct.Biol., 7, 2000
2I9V
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Structural role of Y98 in PYP: effects on fluorescence, gateway and photocycle recovery
Descriptor: 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein
Authors:Savvides, S.N, Kyndt, J.
Deposit date:2006-09-06
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural role of tyrosine 98 in photoactive yellow protein: effects on fluorescence, gateway, and photocycle recovery.
Biochemistry, 46, 2007
2GQ9
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Structure of SYE1, an OYE homologue from S. oneidensis, in complex with p-hydroxybenzaldehyde
Descriptor: FLAVIN MONONUCLEOTIDE, P-HYDROXYBENZALDEHYDE, SULFATE ION, ...
Authors:Savvides, S.N, van den Hemel, D.
Deposit date:2006-04-20
Release date:2006-07-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
J.Biol.Chem., 281, 2006
2GQ8
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Structure of SYE1, an OYE homologue from S. ondeidensis, in complex with p-hydroxyacetophenone
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FLAVIN MONONUCLEOTIDE, P-HYDROXYACETOPHENONE, ...
Authors:Savvides, S.N, van den Hemel, D.
Deposit date:2006-04-20
Release date:2006-07-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
J.Biol.Chem., 281, 2006
1XAN
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HUMAN GLUTATHIONE REDUCTASE IN COMPLEX WITH A XANTHENE INHIBITOR
Descriptor: 3,6-DIHYDROXY-XANTHENE-9-PROPIONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE
Authors:Savvides, S.N, Karplus, P.A.
Deposit date:1996-01-26
Release date:1996-07-11
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor.
J.Biol.Chem., 271, 1996
2GOU
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Structure of wild type, oxidized SYE1, an OYE homologue from S. oneidensis
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FLAVIN MONONUCLEOTIDE, ...
Authors:Savvides, S.N, van den Hemel, D.
Deposit date:2006-04-14
Release date:2006-07-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
J.Biol.Chem., 281, 2006
2GQA
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Structure of NADH-reduced SYE1, an OYE homologue from S. oneidensis
Descriptor: FLAVIN MONONUCLEOTIDE, SULFATE ION, oxidoreductase, ...
Authors:Savvides, S.N, van den Hemel, D.
Deposit date:2006-04-20
Release date:2006-07-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
J.Biol.Chem., 281, 2006
7OX6
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BU of 7ox6 by Molmil
Solution structure of human interleukin-9
Descriptor: Interleukin-9
Authors:Savvides, S.N, Tripsianes, K, De Vos, T, Papageorgiou, A, Evangelidis, T.
Deposit date:2021-06-22
Release date:2022-12-28
Last modified:2023-01-11
Method:SOLUTION NMR
Cite:Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
7QDP
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Crystal structure of FLT3 T343I in complex with the canonical ligand FL
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fms-related tyrosine kinase 3 ligand, ...
Authors:Pannecoucke, E, Savvides, S.N.
Deposit date:2021-11-27
Release date:2022-12-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.691 Å)
Cite:Crystal structure of FLT3 T343I in complex with the canonical ligand FL
To Be Published
7R3N
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BU of 7r3n by Molmil
mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3
Descriptor: Interleukin-12 subunit beta, PHOSPHATE ION, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2022-02-07
Release date:2022-05-04
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Around she goes: the structure of mouse Interleukin-12 p80
To Be Published
8CR6
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BU of 8cr6 by Molmil
mouse Interleukin-12
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit alpha, Interleukin-12 subunit beta, ...
Authors:Merceron, R, Felix, J, Lambert, E, Bloch, Y, Savvides, S.N.
Deposit date:2023-03-07
Release date:2024-02-07
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8CR8
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BU of 8cr8 by Molmil
human Interleukin-23
Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, TERBIUM(III) ION, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-03-08
Release date:2024-02-07
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8CR5
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BU of 8cr5 by Molmil
Murine Interleukin-12 receptor beta 1 domain 1 in complex with murine Interleukin-12 beta.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, Interleukin-12 subunit beta, ...
Authors:Merceron, R, Bloch, Y, Felix, J, Savvides, S.N.
Deposit date:2023-03-07
Release date:2024-02-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
4WRL
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BU of 4wrl by Molmil
Structure of the human CSF-1:CSF-1R complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor, ...
Authors:Felix, J, De Munck, S, Elegheert, J, Savvides, S.N.
Deposit date:2014-10-24
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure, 23, 2015
4WRM
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Structure of the human CSF-1:CSF-1R complex
Descriptor: Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor
Authors:Felix, J, De Munck, S, Elegheert, J, Savvides, S.N.
Deposit date:2014-10-24
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (6.853 Å)
Cite:Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure, 23, 2015
7AL7
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BU of 7al7 by Molmil
The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18, Interleukin-18-binding protein
Authors:Detry, S, Andries, J, Bloch, Y, Clancy, D, Savvides, S.N.
Deposit date:2020-10-05
Release date:2022-04-20
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
J.Biol.Chem., 298, 2022
1ZZH
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Structure of the fully oxidized di-heme cytochrome c peroxidase from R. capsulatus
Descriptor: CALCIUM ION, HEME C, ZINC ION, ...
Authors:De Smet, L, Savvides, S.N, Van Horen, E, Pettigrew, G, Van Beeumen, J.J.
Deposit date:2005-06-14
Release date:2005-11-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and mutagenesis studies on the cytochrome c peroxidase from Rhodobacter capsulatus provide new insights into structure-function relationships of bacterial di-heme peroxidases
J.Biol.Chem., 281, 2006
2B4F
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Structure Of A Cold-Adapted Family 8 Xylanase in complex with substrate
Descriptor: beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, endo-1,4-beta-xylanase
Authors:De Vos, D, Collins, T, Savvides, S.N, Feller, G, Van Beeumen, J.J.
Deposit date:2005-09-23
Release date:2006-09-05
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Oligosaccharide binding in family 8 glycosidases: crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product.
Biochemistry, 45, 2006
5D28
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Complex of GM-CSF/IL-2 inhibition factor with Granulocyte-macrophage colony-stimulating factor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GM-CSF/IL-2 inhibition factor, ...
Authors:Felix, J, Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
5D22
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Structure of ovine granulocyte-macrophage colony-stimulating factor
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Granulocyte-macrophage colony-stimulating factor
Authors:Felix, J, Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016

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