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PDB: 44 results

3T4Z
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BU of 3t4z by Molmil
Crystal Structure of NaK2K Channel Y55W Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-07-26
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
3TCU
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BU of 3tcu by Molmil
Crystal Structure of NaK2K Channel D68E Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-08-09
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
3TET
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BU of 3tet by Molmil
Crystal Structure of NaK2K Channel Y66F Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-08-15
Release date:2011-10-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
7T9F
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BU of 7t9f by Molmil
Structure of VcINDY-apo
Descriptor: DASS family sodium-coupled anion symporter
Authors:Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N.
Deposit date:2021-12-19
Release date:2022-05-25
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY.
Nat Commun, 13, 2022
7T9G
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BU of 7t9g by Molmil
Structure of VcINDY-Na+
Descriptor: DASS family sodium-coupled anion symporter, SODIUM ION
Authors:Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N.
Deposit date:2021-12-19
Release date:2022-05-25
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY.
Nat Commun, 13, 2022
6OL0
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BU of 6ol0 by Molmil
Structure of VcINDY bound to Malate
Descriptor: (2S)-2-hydroxybutanedioic acid, SODIUM ION, Transporter, ...
Authors:Sauer, D.B, Marden, J.J, Wang, D.N.
Deposit date:2019-04-15
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.502 Å)
Cite:Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
Biorxiv, 2022
6OKZ
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BU of 6okz by Molmil
Structure of VcINDY bound to Fumarate
Descriptor: FUMARIC ACID, SODIUM ION, Transporter, ...
Authors:Sauer, D.B, Marden, J, Wang, D.N.
Deposit date:2019-04-15
Release date:2020-10-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.292 Å)
Cite:Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
Biorxiv, 2022
6OL1
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BU of 6ol1 by Molmil
Structure of VcINDY in complex with Succinate
Descriptor: SODIUM ION, SUCCINIC ACID, Transporter, ...
Authors:Sauer, D.B, Marden, J.J, Wang, D.N.
Deposit date:2019-04-15
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.088 Å)
Cite:Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
Biorxiv, 2022
7JSJ
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BU of 7jsj by Molmil
Structure of the NaCT-PF2 complex
Descriptor: (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ...
Authors:Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N.
Deposit date:2020-08-14
Release date:2021-02-24
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Structure and inhibition mechanism of the human citrate transporter NaCT.
Nature, 591, 2021
7JSK
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BU of 7jsk by Molmil
Structure of the NaCT-Citrate complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, SODIUM ION, ...
Authors:Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N.
Deposit date:2020-08-14
Release date:2021-02-24
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structure and inhibition mechanism of the human citrate transporter NaCT.
Nature, 591, 2021
6WU2
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BU of 6wu2 by Molmil
Structure of the LaINDY-malate complex
Descriptor: DASS family sodium-coupled anion symporter, DECANE, HEXANE, ...
Authors:Sauer, D.B, Marden, J.J, Cocco, N, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2020-05-04
Release date:2020-09-16
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
6WTW
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BU of 6wtw by Molmil
Structure of LaINDY crystallized in the presence of alpha-ketoglutarate and malate
Descriptor: DASS family sodium-coupled anion symporter
Authors:Sauer, D.B, Cocco, N, Marden, J.J, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2020-05-04
Release date:2020-09-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
6WTX
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BU of 6wtx by Molmil
Structure of VcINDY in complex with terephthalate
Descriptor: DASS family sodium-coupled anion symporter, SODIUM ION, terephthalic acid
Authors:Sauer, D.B, Marden, J.J, Wang, D.N.
Deposit date:2020-05-04
Release date:2020-09-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
6WU3
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BU of 6wu3 by Molmil
Structure of VcINDY-Na+ in amphipol
Descriptor: VcINDY
Authors:Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N.
Deposit date:2020-05-04
Release date:2020-09-16
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
6WU1
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BU of 6wu1 by Molmil
Structure of apo LaINDY
Descriptor: DASS family sodium-coupled anion symporter, DECANE, HEXANE, ...
Authors:Sauer, D.B, Marden, J.J, Cocco, N.C, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2020-05-04
Release date:2020-09-16
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
6WU4
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BU of 6wu4 by Molmil
Structure of the LaINDY-alpha-ketoglutarate complex
Descriptor: DASS family sodium-coupled anion symporter
Authors:Sauer, D.B, Marden, J.J, Cocco, N, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2020-05-04
Release date:2020-09-16
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
6WW5
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BU of 6ww5 by Molmil
Structure of VcINDY-Na-Fab84 in nanodisc
Descriptor: 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, DASS family sodium-coupled anion symporter, Fab84 Heavy Chain, ...
Authors:Sauer, D.B, Marden, J, Song, J.M, Koide, A, Koide, S, Wang, D.N.
Deposit date:2020-05-07
Release date:2020-09-16
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
3T2M
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BU of 3t2m by Molmil
Crystal Structure of NaK Channel N68D Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-07-22
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T1C
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BU of 3t1c by Molmil
Crystal Structure of NaK Channel D66Y Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-07-21
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T4D
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BU of 3t4d by Molmil
Crystal Structure of NaK2K Channel Y55F Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-07-25
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
8QZ6
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BU of 8qz6 by Molmil
Structure of human ceramide synthase 6 (CerS6) bound to C16:0
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Ceramide synthase 6, ...
Authors:Pascoa, T.C, Pike, A.C.W, Chi, G, Stefanic, S, Quigley, A, Chalk, R, Mukhopadhyay, S.M.M, Venkaya, S, Dix, C, Moreira, T, Tessitore, A, Cole, V, Chu, A, Elkins, J.M, Pautsch, A, Schnapp, G, Carpenter, E.P, Sauer, D.B.
Deposit date:2023-10-26
Release date:2024-11-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of the mechanism and inhibition of a human ceramide synthase
Nature Structural & Molecular Biology, 2024
8QZ7
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BU of 8qz7 by Molmil
Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1
Descriptor: (2~{R})-2-[2-[(5~{R},6~{R},7~{S},9~{S},11~{R},16~{R},18~{S},19~{S})-6-[(3~{R})-3-carboxy-5-oxidanyl-5-oxidanylidene-pentanoyl]oxy-19-(hexadecanoylamino)-5,9-dimethyl-11,16,18-tris(oxidanyl)icosan-7-yl]oxy-2-oxidanylidene-ethyl]butanedioic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pascoa, T.C, Pike, A.C.W, Chi, G, Stefanic, S, Quigley, A, Chalk, R, Mukhopadhyay, S.M.M, Venkaya, S, Dix, C, Moreira, T, Tessitore, A, Cole, V, Chu, A, Elkins, J.M, Pautsch, A, Schnapp, G, Carpenter, E.P, Sauer, D.B.
Deposit date:2023-10-26
Release date:2024-11-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of the mechanism and inhibition of a human ceramide synthase
Nature Structural & Molecular Biology, 2024
9EOT
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BU of 9eot by Molmil
Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Ceramide synthase 6, ...
Authors:Pascoa, T.C, Pike, A.C.W, Chi, G, Stefanic, S, Quigley, A, Chalk, R, Mukhopadhyay, S.M.M, Venkaya, S, Dix, C, Moreira, T, Tessitore, A, Cole, V, Chu, A, Elkins, J.M, Pautsch, A, Schnapp, G, Carpenter, E.P, Sauer, D.B.
Deposit date:2024-03-15
Release date:2024-11-13
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Structural basis of the mechanism and inhibition of a human ceramide synthase
Nature Structural & Molecular Biology, 2024
8P2W
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BU of 8p2w by Molmil
Structure of human SIT1 (focussed map / refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Sodium- and chloride-dependent transporter XTRP3
Authors:Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B.
Deposit date:2023-05-16
Release date:2024-06-12
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
8P2Z
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Structure of human SIT1 bound to L-pipecolate (focussed map / refinement)
Descriptor: (2S)-piperidine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B.
Deposit date:2023-05-16
Release date:2024-06-12
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024

 

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