2V9P
 
 | | Crystal structure of papillomavirus E1 hexameric helicase DNA-free form | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, REPLICATION PROTEIN E1 | | Authors: | Sanders, C.M, Kovalevskiy, O.V, Sizov, D, Lebedev, A.A, Isupov, M.N, Antson, A.A. | | Deposit date: | 2007-08-24 | | Release date: | 2007-10-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Papillomavirus E1 Helicase Assembly Maintains an Asymmetric State in the Absence of DNA and Nucleotide Cofactors.
Nucleic Acids Res., 35, 2007
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2JEX
 | | Transcription activator structure reveals redox control of a replication initiation reaction | | Descriptor: | REGULATORY PROTEIN E2 | | Authors: | Sanders, C.M, Sizov, D, Seavers, P.R, Ortiz-Lombardia, M, Antson, A.A. | | Deposit date: | 2007-01-24 | | Release date: | 2007-05-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Transcription Activator Structure Reveals Redox Control of a Replication Initiation Reaction.
Nucleic Acids Res., 35, 2007
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2JEU
 | | Transcription activator structure reveals redox control of a replication initiation reaction | | Descriptor: | REGULATORY PROTEIN E2 | | Authors: | Sanders, C.M, Sizov, D, Seavers, P.R, Ortiz-Lombardia, M, Antson, A.A. | | Deposit date: | 2007-01-23 | | Release date: | 2007-05-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Transcription Activator Structure Reveals Redox Control of a Replication Initiation Reaction.
Nucleic Acids Res., 35, 2007
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6HPQ
 | | Crystal structure of human Pif1 helicase in complex with AMP-PNP, brominated crystal form. | | Descriptor: | ATP-dependent DNA helicase PIF1, BROMIDE ION, MAGNESIUM ION, ... | | Authors: | Ledikov, V.M, Dehghani-Tafti, S, Bax, B, Sanders, C.M, Antson, A.A. | | Deposit date: | 2018-09-21 | | Release date: | 2019-01-23 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 47, 2019
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7APD
 | | Bovine Papillomavirus E1 DNA helicase-replication fork complex | | Descriptor: | DNA (36-MER), DNA (40-MER), Replication protein E1 | | Authors: | Javed, A, Major, B, Stead, J, Sanders, C.M, Orlova, E.V. | | Deposit date: | 2020-10-16 | | Release date: | 2021-11-17 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Unwinding of a DNA replication fork by a hexameric viral helicase.
Nat Commun, 12, 2021
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5A9K
 | | Structural basis for DNA strand separation by a hexameric replicative helicase | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, REPLICATION PROTEIN E1 | | Authors: | Chaban, Y, Stead, J.A, Ryzhenkova, K, Whelan, F, Lamber, K, Antson, F, Sanders, C.M, Orlova, E.V. | | Deposit date: | 2015-07-21 | | Release date: | 2015-08-26 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (19 Å) | | Cite: | Structural Basis for DNA Strand Separation by a Hexameric Replicative Helicase.
Nucleic Acids Res., 43, 2015
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9FI9
 | | Human PIF + Z48847594 (OCCUPANCY 0.7) | | Descriptor: | ATP-dependent DNA helicase PIF1, MAGNESIUM ION, N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide, ... | | Authors: | Bax, B.D, Sanders, C.M, Antson, A.A, Brandao-Neto, J. | | Deposit date: | 2024-05-28 | | Release date: | 2024-10-02 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.727 Å) | | Cite: | Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1.
Nucleic Acids Res., 52, 2024
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9FB8
 | | XChem refined PIF1-x0076 complex | | Descriptor: | ATP-dependent DNA helicase PIF1, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... | | Authors: | Bax, B.D, Antson, A.A, Sanders, C.M, Brandao-Neto, J. | | Deposit date: | 2024-05-12 | | Release date: | 2024-09-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.727 Å) | | Cite: | Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1.
Nucleic Acids Res., 52, 2024
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1DTO
 | | CRYSTAL STRUCTURE OF THE COMPLETE TRANSACTIVATION DOMAIN OF E2 PROTEIN FROM THE HUMAN PAPILLOMAVIRUS TYPE 16 | | Descriptor: | REGULATORY PROTEIN E2 | | Authors: | Antson, A.A, Burns, J.E, Moroz, O.V, Scott, D.J, Sanders, C.M, Bronstein, I.B, Dodson, G.G, Wilson, K.S, Maitland, N. | | Deposit date: | 2000-01-13 | | Release date: | 2000-02-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the intact transactivation domain of the human papillomavirus E2 protein.
Nature, 403, 2000
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6HPU
 | | Crystal structure of human Pif1 helicase in complex with ADP-AlF4 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase PIF1, MAGNESIUM ION, ... | | Authors: | Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A. | | Deposit date: | 2018-09-21 | | Release date: | 2019-01-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.96 Å) | | Cite: | Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 47, 2019
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6HPH
 | | Crystal structure of human Pif1 helicase in complex with AMP-PNP | | Descriptor: | ATP-dependent DNA helicase PIF1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A. | | Deposit date: | 2018-09-20 | | Release date: | 2019-01-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.13 Å) | | Cite: | Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 47, 2019
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6HPT
 | | Crystal structure of human Pif1 helicase, apoform. | | Descriptor: | ATP-dependent DNA helicase PIF1, SULFATE ION | | Authors: | Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A. | | Deposit date: | 2018-09-21 | | Release date: | 2019-01-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 47, 2019
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1VYX
 | | Solution structure of the KSHV K3 N-terminal domain | | Descriptor: | ORF K3, ZINC ION | | Authors: | Dodd, R.B, Allen, M.D, Brown, S.E, Sanderson, C.M, Duncan, L.M, lehner, P.J, Bycroft, M, Read, R.J. | | Deposit date: | 2004-05-07 | | Release date: | 2004-10-01 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the Kaposi'S Sarcoma-Associated Herpesvirus K3 N-Terminal Domain Reveals a Novel E2-Binding C4Hc3-Type Ring Domain
J.Biol.Chem., 279, 2004
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