4BUP
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![BU of 4bup by Molmil](/molmil-images/mine/4bup) | A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases | 分子名称: | GLYCEROL, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1, S-ADENOSYLMETHIONINE, ... | 著者 | Southall, S.M, Cronin, N.B, Wilson, J.R. | 登録日 | 2013-06-21 | 公開日 | 2013-10-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.166 Å) | 主引用文献 | A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases. Nucleic Acids Res., 42, 2014
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7L1U
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![BU of 7l1u by Molmil](/molmil-images/mine/7l1u) | Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB) | 分子名称: | Engineered Guanine nucleotide-binding protein subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Hong, C, Byrne, N.J, Zamlynny, B, Tummala, S, Xiao, L, Shipman, J.M, Partridge, A.T, Minnick, C, Breslin, M.J, Rudd, M.T, Stachel, S.J, Rada, V.L, Kern, J.C, Armacost, K.A, Hollingsworth, S.A, O'Brien, J.A, Hall, D.L, McDonald, T.P, Strickland, C, Brooun, A, Soisson, S.M, Hollenstein, K. | 登録日 | 2020-12-15 | 公開日 | 2021-02-10 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation. Nat Commun, 12, 2021
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7L1V
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![BU of 7l1v by Molmil](/molmil-images/mine/7l1v) | Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1 | 分子名称: | 4'-methoxy-N,N-dimethyl-3'-{[3-(2-{[2-(2H-1,2,3-triazol-2-yl)benzene-1-carbonyl]amino}ethyl)phenyl]sulfamoyl}[1,1'-biphenyl]-3-carboxamide, Engineered Guanine nucleotide-binding protein subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hong, C, Byrne, N.J, Zamlynny, B, Tummala, S, Xiao, L, Shipman, J.M, Partridge, A.T, Minnick, C, Breslin, M.J, Rudd, M.T, Stachel, S.J, Rada, V.L, Kern, J.C, Armacost, K.A, Hollingsworth, S.A, O'Brien, J.A, Hall, D.L, McDonald, T.P, Strickland, C, Brooun, A, Soisson, S.M, Hollenstein, K. | 登録日 | 2020-12-15 | 公開日 | 2021-02-10 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation. Nat Commun, 12, 2021
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6Y55
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![BU of 6y55 by Molmil](/molmil-images/mine/6y55) | The crystal structure of glycogen phosphorylase in complex with 43 | 分子名称: | 2-(3-methylphenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form | 著者 | Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D. | 登録日 | 2020-02-24 | 公開日 | 2020-08-19 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102, 2020
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7L7Q
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![BU of 7l7q by Molmil](/molmil-images/mine/7l7q) | Ctf3c with Ulp2-KIM | 分子名称: | Inner kinetochore subunit CTF3, Inner kinetochore subunit MCM16, Inner kinetochore subunit MCM22 | 著者 | Hinshaw, S.M, Harrison, S.C. | 登録日 | 2020-12-30 | 公開日 | 2021-02-10 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore. J.Cell Biol., 220, 2021
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7KJ8
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![BU of 7kj8 by Molmil](/molmil-images/mine/7kj8) | Wild-type epi-isozizaene synthase: complex with 3 Mg2+ and pamidronate | 分子名称: | MAGNESIUM ION, PAMIDRONATE, SULFATE ION, ... | 著者 | Ronnebaum, T.A, Gardner, S.M, Christianson, D.W. | 登録日 | 2020-10-26 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | An Aromatic Cluster in the Active Site of epi -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways. Biochemistry, 59, 2020
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2AR9
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![BU of 2ar9 by Molmil](/molmil-images/mine/2ar9) | Crystal structure of a dimeric caspase-9 | 分子名称: | Caspase-9, D-MALATE | 著者 | Chao, Y, Shiozaki, E.N, Srinivassula, S.M, Rigotti, D.J, Fairman, R, Shi, Y. | 登録日 | 2005-08-19 | 公開日 | 2005-10-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Engineering a Dimeric Caspase-9: A Re-Evaluation of the Induced Proximity Model for Caspase Activation PLOS BIOL., 3, 2005
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2AXP
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![BU of 2axp by Molmil](/molmil-images/mine/2axp) | X-Ray Crystal Structure of Protein BSU20280 from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR256. | 分子名称: | hypothetical protein BSU20280 | 著者 | Forouhar, F, Abashidze, M, Friedman, D, Vorobiev, S.M, Kuzin, A.P, Ciao, M, Conover, K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2005-09-05 | 公開日 | 2005-09-13 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of the Hypothetical Protein BSU20280 from Bacillus subtilis, NESG target SR256 To be Published
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2B19
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7KHD
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![BU of 7khd by Molmil](/molmil-images/mine/7khd) | Human GITR-GITRL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18 | 著者 | Wang, F, Chau, B, West, S.M, Strop, P. | 登録日 | 2020-10-21 | 公開日 | 2021-03-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.956102 Å) | 主引用文献 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun, 12, 2021
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2AZE
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![BU of 2aze by Molmil](/molmil-images/mine/2aze) | Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer | 分子名称: | Retinoblastoma-associated protein, Transcription factor Dp-1, Transcription factor E2F1 | 著者 | Rubin, S.M, Gall, A.L, Zheng, N, Pavletich, N.P. | 登録日 | 2005-09-10 | 公開日 | 2006-01-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell(Cambridge,Mass.), 123, 2005
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7KHX
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![BU of 7khx by Molmil](/molmil-images/mine/7khx) | Mouse GITR-GITRL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, ... | 著者 | Wang, F, Chau, B, West, S.M, Strop, P. | 登録日 | 2020-10-22 | 公開日 | 2021-03-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.20569849 Å) | 主引用文献 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun, 12, 2021
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1ZTR
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![BU of 1ztr by Molmil](/molmil-images/mine/1ztr) | Solution structure of Engrailed homeodomain L16A mutant | 分子名称: | Segmentation polarity homeobox protein engrailed | 著者 | Religa, T.L, Markson, J.S, Mayor, U, Freund, S.M.V, Fersht, A.R. | 登録日 | 2005-05-27 | 公開日 | 2005-10-18 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a protein denatured state and folding intermediate. Nature, 437, 2005
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4A39
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![BU of 4a39 by Molmil](/molmil-images/mine/4a39) | Metallo-carboxypeptidase from Pseudomonas Aeruginosa in complex with (2-guanidinoethylmercapto)succinic acid | 分子名称: | (2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID, METALLO-CARBOXYPEPTIDASE, ZINC ION | 著者 | Otero, A, Rodriguez de la Vega, M, Tanco, S.M, Lorenzo, J, Aviles, F.X, Reverter, D. | 登録日 | 2011-09-30 | 公開日 | 2012-05-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The Novel Structure of a Cytosolic M14 Metallocarboxypeptidase (Ccp) from Pseudomonas Aeruginosa: A Model for Mammalian Ccps. Faseb J., 26, 2012
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7KRR
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![BU of 7krr by Molmil](/molmil-images/mine/7krr) | Structural impact on SARS-CoV-2 spike protein by D614G substitution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Cai, Y.F, Xiao, T.S, Lu, J.M, Peng, H.Q, Sterling, S.M, Walsh Jr, R.M, Volloch, S.R, Zhu, H.S, Woosley, A.N, Yang, W, Sliz, P, Chen, B. | 登録日 | 2020-11-20 | 公開日 | 2021-03-24 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural impact on SARS-CoV-2 spike protein by D614G substitution. Science, 372, 2021
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7KRS
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![BU of 7krs by Molmil](/molmil-images/mine/7krs) | Structural impact on SARS-CoV-2 spike protein by D614G substitution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Cai, Y.F, Xiao, T.S, Lu, J.M, Peng, H.Q, Sterling, S.M, Walsh Jr, R.M, Volloch, S.R, Zhu, H.S, Woosley, A.N, Yang, W, Sliz, P, Chen, B. | 登録日 | 2020-11-20 | 公開日 | 2021-03-24 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural impact on SARS-CoV-2 spike protein by D614G substitution. Science, 372, 2021
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7KRQ
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![BU of 7krq by Molmil](/molmil-images/mine/7krq) | Structural impact on SARS-CoV-2 spike protein by D614G substitution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Cai, Y.F, Xiao, T.S, Lu, J.M, Peng, H.Q, Sterling, S.M, Walsh Jr, R.M, Volloch, S.R, Zhu, H.S, Woosley, A.N, Yang, W, Sliz, P, Chen, B. | 登録日 | 2020-11-20 | 公開日 | 2021-03-31 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Structural impact on SARS-CoV-2 spike protein by D614G substitution. Science, 372, 2021
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2A93
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![BU of 2a93 by Molmil](/molmil-images/mine/2a93) | NMR SOLUTION STRUCTURE OF THE C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER, 40 STRUCTURES | 分子名称: | C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER | 著者 | Lavigne, P, Crump, M.P, Gagne, S.M, Hodges, R.S, Kay, C.M, Sykes, B.D. | 登録日 | 1998-06-09 | 公開日 | 1999-01-27 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. J.Mol.Biol., 281, 1998
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6YS8
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6Y5C
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![BU of 6y5c by Molmil](/molmil-images/mine/6y5c) | The crystal structure of glycogen phosphorylase in complex with 52 | 分子名称: | 2-(4-methylphenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form | 著者 | Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D. | 登録日 | 2020-02-25 | 公開日 | 2020-08-19 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102, 2020
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1ZQ7
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![BU of 1zq7 by Molmil](/molmil-images/mine/1zq7) | X-Ray Crystal Structure of Protein Q8PZK8 from Methanosarcina mazei. Northeast Structural Genomics Consortium Target MaR9. | 分子名称: | Hypothetical protein MM0484 | 著者 | Kuzin, A.P, Abashidze, M, Vorobiev, S.M, Yong, W, Xiao, R, Ma, L.-C, Acton, T, Montelione, G.T, Tong, L, Hunt, J, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2005-05-18 | 公開日 | 2005-05-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | X-Ray structure of the hypothetical protein Q8PZK8 from Methanosarcina mazei at the resolution 2.1A. Northeast Structural Genomics Consortium target MaR9. To be Published
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2BJQ
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![BU of 2bjq by Molmil](/molmil-images/mine/2bjq) | Crystal structure of the nematode sperm cell motility protein MFP2 | 分子名称: | MFP2A | 著者 | Grant, R.P, Buttery, S.M, Ekman, G.C, Roberts, T.M, Stewart, M. | 登録日 | 2005-02-07 | 公開日 | 2005-03-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structure of Mfp2 and its Function in Enhancing Msp Polymerization in Ascaris Sperm Amoeboid Motility J.Mol.Biol., 347, 2005
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2BY1
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![BU of 2by1 by Molmil](/molmil-images/mine/2by1) | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ... | 著者 | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | 登録日 | 2005-07-28 | 公開日 | 2006-02-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection? Acta Crystallogr.,Sect.D, 62, 2006
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2BY2
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![BU of 2by2 by Molmil](/molmil-images/mine/2by2) | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ... | 著者 | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | 登録日 | 2005-07-28 | 公開日 | 2006-02-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection? Acta Crystallogr.,Sect.D, 62, 2006
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4CE3
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![BU of 4ce3 by Molmil](/molmil-images/mine/4ce3) | Hsp90 N-terminal domain bound to macrolactam analogues of radicicol. | 分子名称: | 13-Chloro-14,16-dihydroxy-2-methyl-2,3,4,5,9,10-hexahydrobenz[c][1]azacyclotetradecine-1,11(8H,12H)-dione, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | 著者 | Roe, S.M, Parry-Morris, S, Prodromou, C. | 登録日 | 2013-11-08 | 公開日 | 2014-01-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Synthesis of Macrolactam Analogues of Radicicol and Their Binding to Heat Shock Protein Hsp90. Org.Biomol.Chem., 12, 2014
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