2GAB
 
 | | Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl | | Descriptor: | 3,3',4',5-TETRACHLOROBIPHENYL-4-OL, Transthyretin | | Authors: | Palaninathan, S.K, Smith, C, Safe, S.H, Kelly, J.W, Sacchettini, J.C. | | Deposit date: | 2006-03-08 | | Release date: | 2006-03-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity
Chem.Biol., 11, 2004
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8FSR
 | | Complex Structure of YejA with fMccA | | Descriptor: | Peptide Precursor of Microcin C7, YejA | | Authors: | Naik, S.K, Dong, S.-H. | | Deposit date: | 2023-01-11 | | Release date: | 2024-02-07 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Trojan Horse Peptide Conjugates Remodel the Activity Spectrum of Clinical Antibiotics
To Be Published
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2FQ2
 | | Solution structure of minor conformation of holo-acyl carrier protein from malaria parasite plasmodium falciparum | | Descriptor: | 4'-PHOSPHOPANTETHEINE, acyl carrier protein | | Authors: | Sharma, A.K, Sharma, S.K, Surolia, A, Surolia, N, Sarma, S.P. | | Deposit date: | 2006-01-17 | | Release date: | 2006-08-08 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs
Biochemistry, 45, 2006
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7NWI
 | | Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA+BlaS, 40S ribosomal protein S11, ... | | Authors: | Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C. | | Deposit date: | 2021-03-16 | | Release date: | 2021-07-07 | | Last modified: | 2023-01-11 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
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2G0D
 | | Nisin cyclase | | Descriptor: | Nisin biosynthesis protein nisC, ZINC ION | | Authors: | Nair, S.K. | | Deposit date: | 2006-02-12 | | Release date: | 2006-05-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis
Science, 311, 2006
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8FY1
 | | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | | Deposit date: | 2023-01-25 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
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8FY2
 | | E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | | Deposit date: | 2023-01-25 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
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8FY0
 | | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | | Descriptor: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | | Authors: | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | | Deposit date: | 2023-01-25 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
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8FSQ
 | | Complex Structure of YejA with Microcin C7 | | Descriptor: | 5'-O-[(R)-amino(3-aminopropoxy)phosphoryl]adenosine, Microcin C7 peptide portion, YejA | | Authors: | Naik, S.K, Dong, S.-H. | | Deposit date: | 2023-01-11 | | Release date: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Trojan Horse Peptide Conjugates Remodel the Activity Spectrum of Clinical Antibiotics
To Be Published
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5EHK
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6WN0
 | | The structure of a CoA-dependent acyl-homoserine lactone synthase, RpaI, with the adduct of SAH and p-coumaroyl CoA | | Descriptor: | (2S)-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)-2-{[(2E)-3-(cis-4-hydroxycyclohexa-2,5-dien-1-yl)prop-2-enoyl]amino}butanoic acid, 4-coumaroyl-homoserine lactone synthase, COENZYME A | | Authors: | Dong, S.-H, Nair, S.K. | | Deposit date: | 2020-04-22 | | Release date: | 2020-05-13 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities.
Acs Chem.Biol., 15, 2020
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6WUU
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1YDC
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5EKQ
 | | The structure of the BamACDE subcomplex from E. coli | | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, Outer membrane protein assembly factor BamD, ... | | Authors: | Bakelar, J, Buchanan, S.K, Noinaj, N. | | Deposit date: | 2015-11-04 | | Release date: | 2016-01-20 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.392 Å) | | Cite: | The structure of the beta-barrel assembly machinery complex.
Science, 351, 2016
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8CWX
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6WIL
 | | CdiB from Acinetobacter baumannii | | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, DI(HYDROXYETHYL)ETHER, Hemolysin activator protein CdiB, ... | | Authors: | Guerin, J, Botos, I, Buchanan, S.K. | | Deposit date: | 2020-04-10 | | Release date: | 2020-11-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural insight into toxin secretion by contact dependent growth inhibition transporters.
Elife, 9, 2020
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8D3Q
 | | Type I-C Cas4-Cas1-Cas2 complex bound to a PAM/NoPAM prespacer | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endonuclease Cas2, CRISPR-associated exonuclease Cas4, ... | | Authors: | Dhingra, Y, Suresh, S.K, Juneja, P, Sashital, D.G. | | Deposit date: | 2022-06-01 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
Mol.Cell, 82, 2022
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8D3M
 | | Type I-C Cas4-Cas1-Cas2 complex bound to a PAM/Processed prespacer | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endonuclease Cas2, CRISPR-associated exonuclease Cas4, ... | | Authors: | Dhingra, Y, Suresh, S.K, Juneja, P, Sashital, D.G. | | Deposit date: | 2022-06-01 | | Release date: | 2022-11-02 | | Last modified: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
Mol.Cell, 82, 2022
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6WUI
 | | Crystal Structure of mutant S. pombe Rai1 (E150S/E199Q/E239Q) in complex with 3'-FADP | | Descriptor: | Decapping nuclease din1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) | | Authors: | Doamekpor, S.K, Tong, L. | | Deposit date: | 2020-05-04 | | Release date: | 2020-05-20 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
Nucleic Acids Res., 48, 2020
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6WPA
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2GHH
 | | Conformational mobility in the active site of a heme peroxidase | | Descriptor: | NITRIC OXIDE, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Badyal, S.K, Joyce, M.G, Sharp, K.H, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2006-03-27 | | Release date: | 2006-06-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.013 Å) | | Cite: | Conformational Mobility in the Active Site of a Heme Peroxidase.
J.Biol.Chem., 281, 2006
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5DM0
 | | Crystal structure of the plantazolicin methyltransferase BamL in complex with triazolic desmethylPZN analog and SAH | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ethyl 2-(2-{2-[(1S)-1-amino-4-carbamimidamidobutyl]-1,3-thiazol-4-yl}-5-methyl-1,3-oxazol-4-yl)-1,3-thiazole-4-carboxylate, ... | | Authors: | Hao, Y, Nair, S.K. | | Deposit date: | 2015-09-07 | | Release date: | 2015-09-23 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.
Acs Chem.Biol., 10, 2015
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8D3L
 | | Type I-C Cas4-Cas1-Cas2 complex bound to a PAM/PAM prespacer | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endonuclease Cas2, CRISPR-associated exonuclease Cas4, ... | | Authors: | Dhingra, Y, Suresh, S.K, Juneja, P, Sashital, D.G. | | Deposit date: | 2022-06-01 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
Mol.Cell, 82, 2022
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5DNK
 | | The structure of PKMT1 from Rickettsia prowazekii in complex with AdoHcy | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, protein lysine methyltransferase 1 | | Authors: | Noinaj, N, Abeykoon, A, He, Y, Yang, D.C, Buchanan, S.K. | | Deposit date: | 2015-09-10 | | Release date: | 2016-08-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia.
J.Biol.Chem., 291, 2016
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8D3P
 | | Type I-C Cas4-Cas1-Cas2 complex bound to half-site integration intermediate (HSI) | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endonuclease Cas2, CRISPR-associated exonuclease Cas4, ... | | Authors: | Dhingra, Y, Suresh, S.K, Juneja, P, Sashital, D.G. | | Deposit date: | 2022-06-01 | | Release date: | 2022-11-02 | | Last modified: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (4.26 Å) | | Cite: | PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
Mol.Cell, 82, 2022
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