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PDB: 18 件
4X4J
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Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Putative oxygenase, SULFATE ION
著者Tsai, S.-C, Jackson, D.R, Patel, A, Barajas, J.F, Rohr, J, Yu, X, Liu, H.-W, Sasaki, E, Calveras, J, Metsa-Ketela, M.
登録日2014-12-02
公開日2015-12-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
To Be Published
6OVQ
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Crystal structure of mithramycin 3-side chain keto-reductase MtmW
分子名称: GLYCEROL, Putative Side chain reductase
著者Hou, C, Yu, X, Rohr, J, Tsodikov, O.V.
登録日2019-05-08
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis.
Angew.Chem.Int.Ed.Engl., 59, 2020
3FMW
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The crystal structure of MtmOIV, a Baeyer-Villiger monooxygenase from the mithramycin biosynthetic pathway in Streptomyces argillaceus.
分子名称: 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, Oxygenase
著者Noinaj, N, Beam, M.P, Wang, C, Rohr, J.
登録日2008-12-22
公開日2009-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway .
Biochemistry, 48, 2009
6OW0
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Crystal structure of mithramycin 3-side chain keto-reductase MtmW in complex with NAD+ and PEG
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, MtmW, ...
著者Hou, C, Yu, X, Rohr, J, Tsodikov, O.V.
登録日2019-05-08
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis.
Angew.Chem.Int.Ed.Engl., 59, 2020
6OVX
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Crystal structure of mithramycin 3-side chain keto-reductase MtmW in complex with NAD+, P422 form
分子名称: GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative side chain reductase
著者Hou, C, Yu, X, Rohr, J, Tsodikov, O.V.
登録日2019-05-08
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis.
Angew.Chem.Int.Ed.Engl., 59, 2020
3POP
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BU of 3pop by Molmil
The crystal structure of GilR, an oxidoreductase that catalyzes the terminal step of gilvocarcin biosynthesis
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GilR oxidase
著者Noinaj, N, Bosserman, M.A, Schickli, M.A, Kharel, M.K, Rohr, J, Buchanan, S.K.
登録日2010-11-23
公開日2011-05-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis.
J.Biol.Chem., 286, 2011
3PQB
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The crystal structure of pregilvocarcin in complex with GilR, an oxidoreductase that catalyzes the terminal step of gilvocarcin biosynthesis
分子名称: (1R)-1,4-anhydro-6-deoxy-1-[(6R)-8-ethenyl-1,6-dihydroxy-10,12-dimethoxy-6H-dibenzo[c,h]chromen-4-yl]-D-galactitol, FLAVIN-ADENINE DINUCLEOTIDE, Putative oxidoreductase
著者Noinaj, N, Bosserman, M.A, Schickli, M.A, Kharel, M.K, Rohr, J, Buchanan, S.K.
登録日2010-11-25
公開日2011-05-11
最終更新日2011-08-03
実験手法X-RAY DIFFRACTION (2.324 Å)
主引用文献The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis.
J.Biol.Chem., 286, 2011
6VGG
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Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC
分子名称: Core-binding factor subunit beta, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ...
著者Hou, C, Rohr, J, Tsodikov, O.V.
登録日2020-01-08
公開日2020-11-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.31 Å)
主引用文献Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.
Structure, 29, 2021
4K5R
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The 2.0 angstrom crystal structure of MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus.
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Oxygenase
著者Noinaj, N, Bosserman, M.A, Rohr, J, Buchanan, S.K.
登録日2013-04-15
公開日2013-10-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin.
Acs Chem.Biol., 8, 2013
4K5S
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The crystal structure of premithramycin B in complex with MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus.
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Oxygenase, premithramycin B
著者Noinaj, N, Bosserman, M.A, Rohr, J, Buchanan, S.K.
登録日2013-04-15
公開日2013-10-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin.
Acs Chem.Biol., 8, 2013
5JW2
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Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGATCCCT
分子名称: DNA (5'-D(*AP*GP*GP*GP*AP*TP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ...
著者Hou, C, Rohr, J, Tsodikov, O.V.
登録日2016-05-11
公開日2016-09-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.
Nucleic Acids Res., 44, 2016
5JVW
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Crystal structure of mithramycin analogue MTM SA-Trp in complex with a 10-mer DNA AGAGGCCTCT.
分子名称: DNA (5'-D(*AP*GP*AP*GP*GP*CP*CP*TP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Trp, ...
著者Hou, C, Rohr, J, Tsodikov, O.V.
登録日2016-05-11
公開日2016-09-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.
Nucleic Acids Res., 44, 2016
5JW0
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Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGTACCCT
分子名称: DNA (5'-D(P*AP*GP*GP*GP*TP*AP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ...
著者Hou, C, Rohr, J, Tsodikov, O.V.
登録日2016-05-11
公開日2016-09-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.
Nucleic Acids Res., 44, 2016
4RVH
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BU of 4rvh by Molmil
Crystal structure of MtmC in complex with SAH and TDP-4-keto-D-olivose
分子名称: D-mycarose 3-C-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ...
著者Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J.
登録日2014-11-26
公開日2015-01-28
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain.
Biochemistry, 54, 2015
4RVG
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Crystal structure of MtmC in complex with SAM and TDP
分子名称: ACETATE ION, D-mycarose 3-C-methyltransferase, S-ADENOSYLMETHIONINE, ...
著者Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J.
登録日2014-11-26
公開日2015-01-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain.
Biochemistry, 54, 2015
4RVF
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Crystal structure of MtmC in complex with TDP
分子名称: D-mycarose 3-C-methyltransferase, THYMIDINE-5'-DIPHOSPHATE, ZINC ION
著者Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J.
登録日2014-11-26
公開日2015-01-28
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain.
Biochemistry, 54, 2015
4RV9
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Crystal structure of MtmC in complex with SAH
分子名称: ACETATE ION, CHLORIDE ION, D-mycarose 3-C-methyltransferase, ...
著者Hou, C, Chen, J.-M, Rohr, J, Tsodikov, O.V.
登録日2014-11-25
公開日2015-02-04
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain.
Biochemistry, 54, 2015
4RVD
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Crystal structure of MtmC in complex with SAM
分子名称: ACETATE ION, D-mycarose 3-C-methyltransferase, S-ADENOSYLMETHIONINE, ...
著者Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J.
登録日2014-11-26
公開日2015-01-28
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain.
Biochemistry, 54, 2015

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