4K5S

The crystal structure of premithramycin B in complex with MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus.

Summary for 4K5S

Entry DOI	10.2210/pdb4k5s/pdb
Related	4K5R
Descriptor	Oxygenase, FLAVIN-ADENINE DINUCLEOTIDE, premithramycin B, ... (4 entities in total)
Functional Keywords	oxygenase, mithramycin, baeyer-villiger, flavin binding protein, oxidoreductase, rossmann fold, fad binding protein
Biological source	Streptomyces argillaceus
Total number of polymer chains	1
Total formula weight	59188.32
Authors	Noinaj, N.,Bosserman, M.A.,Rohr, J.,Buchanan, S.K. (deposition date: 2013-04-15, release date: 2013-10-09, Last modification date: 2024-02-28)
Primary citation	Bosserman, M.A.,Downey, T.,Noinaj, N.,Buchanan, S.K.,Rohr, J. Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin. Acs Chem.Biol., 8:2466-2477, 2013 Cited by PubMed: 23992662 DOI: 10.1021/cb400399b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation