4K5S
The crystal structure of premithramycin B in complex with MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus.
Summary for 4K5S
Entry DOI | 10.2210/pdb4k5s/pdb |
Related | 4K5R |
Descriptor | Oxygenase, FLAVIN-ADENINE DINUCLEOTIDE, premithramycin B, ... (4 entities in total) |
Functional Keywords | oxygenase, mithramycin, baeyer-villiger, flavin binding protein, oxidoreductase, rossmann fold, fad binding protein |
Biological source | Streptomyces argillaceus |
Total number of polymer chains | 1 |
Total formula weight | 59188.32 |
Authors | Noinaj, N.,Bosserman, M.A.,Rohr, J.,Buchanan, S.K. (deposition date: 2013-04-15, release date: 2013-10-09, Last modification date: 2024-02-28) |
Primary citation | Bosserman, M.A.,Downey, T.,Noinaj, N.,Buchanan, S.K.,Rohr, J. Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin. Acs Chem.Biol., 8:2466-2477, 2013 Cited by PubMed: 23992662DOI: 10.1021/cb400399b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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