4K5S

The crystal structure of premithramycin B in complex with MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Oxygenase	polymer	536	57309.6	1	UniProt (Q194P4) Pfam (PF01494) Pfam (PF21274)	Streptomyces argillaceus
2	B (A)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	1	Chemie (FAD)
3	C (A)	premithramycin B	non-polymer		1093.1	1	Chemie (PM0)
4	D (A)	water	water		18.0	508	Chemie (HOH)

Sequence modifications

A: 1 - 533 (UniProt: Q194P4)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ala 106	Gly 106	SEE REMARK 999
Arg 129	Pro 129	SEE REMARK 999
Gly 136	Arg 136	SEE REMARK 999
Arg 156	Pro 156	SEE REMARK 999
Ala 162	Gly 162	SEE REMARK 999
Gly 177	Ala 177	SEE REMARK 999
Ile 178	Asp 178	SEE REMARK 999
Gly 179	Arg 179	SEE REMARK 999
Arg 225	Pro 225	SEE REMARK 999
Val 226	Gly 226	SEE REMARK 999
Val 227	Trp 227	SEE REMARK 999
Val 228	Ser 228	SEE REMARK 999
Ile 229	Ser 229	SEE REMARK 999
Glu 230	Ser 230	SEE REMARK 999
Tyr 231	Ser 231	SEE REMARK 999
Pro 403	Ser 403	SEE REMARK 999
Ala 410	Pro 410	SEE REMARK 999
Gly 421	Arg 421	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	57309.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1878.7
All*	Total formula weight	59188.3

*Water molecules are not included.